
Majid Hafezparast
Molecular mechanisms of Motor Neuron Disease
To design therapeutics for neurodegenerative diseases, we must first understand the causes.” louise serpell
Professor of Biochemistry
Neurodegenerative diseases are associated with progressive deterioration of brain function. Many are sporadic, with aging being biggest risk factor, but hereditary forms can provide further understanding of the cause. Researchers in Sussex Neuroscience are studying the underlying genetic, molecular, cellular, behavourial and functional changes that are associated with conditions including Alzheimer’s, Parkinson’s and Huntington’s disease, frontotemporal dementia and motor neuron disease. Focussed and multidisciplinary studies are addressing the underlying triggers of disease, causes and the hall-marks of progression, paving the way to development of therapeutics.
Molecular mechanisms of Motor Neuron Disease
Structure and function of amyloidogenic peptides and proteins
Synapses: function and dysfunction in learning and disease
Development and disorders of motor neurons
Neurodegenerative diseases
Quantitative imaging techniques; biomarkers of disease
Motor Neuron Disease
Episodic memory
Brain energy supply and demand
Molecular neuroscience of addiction and neurodegeneration
Memory, attention and information processing across the lifespan
Spatiotemporal statistical modelling; Morphometry and imaging biomarkers