School of Life Sciences

Spencer Lab

Welcome to the Spencer group website.


latest paper is out!

(N-Heterocyclic Carbene)2‑Pd(0)-Catalyzed Silaboration of Internal and Terminal Alkynes: Scope and Mechanistic Studies. Ansell, M. B.; Spencer, J.* Navarro, O.* ACS Catal. 2016, 6, 2192−2196. Si-B bonds can be stereoselectively added across alkynes, mechanistic studies show an oxidative addition of the Si-B bond to the Pd(0) catalyst.


Congratulations to Poj, who  presented a poster at the 14th Ferrocene colloquium, Konstanz.

We are grateful for a Doctoral Overseas Conference (Sussex) for funding this.


Melvyn Ansell will spend 3 months in the Braunschweig group, Wurzburg, courtesy of a Royal Society of Chemistry Researcher Mobility grant award


Gavin Roffe presented a poster entitled ‘A Synthesis, Catalytic Application, and Theoretical Investigation into N’CN, SCN and PCS Pincer Palladacycles’ at:

Again, thanks to Sussex for a travel award!






Chem Sci. just accepted with Diamond/SGC.

A Poised Fragment Library Enables Rapid Synthetic Expansion Yielding the First Reported Inhibitors of PHIP(2), an Atypical Bromodomain. Cox, O. B., Krojer, T.; Collins, P.; Monteiro, O.; Talon, R.; Bradley, A.; Fedorov, O.;  Amin, J.; Marsden, B. D.; Spencer, J.;  Von Delft, F.*; Brennan, P. E.* Chem. Sci. 2016, 7, 2322-2330. First examples of hits vs PHIP(2), a melanoma target, collaboration with SGC, Oxford.


See also:


 Our 1st paper with LMB from our Worldwide Cancer Research grant now out. Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53. Joerger, A.* C.; Bauer, M. R.; Wilcken, R.; Baud, M. G.; Harbrecht, H.; Exner, T. E.; Boeckler, F. M.; Spencer, J.; Fersht, A. R. Structure, 2015, 23, 2246–2255. (IF=5.6).





Group "us"ie; 1-10-14: LHS JS,