Welcome to the Spencer group website
The Spencer group conducts research on the interface of chemistry and medicinal chemistry, making use of transition metal catalysis and microwave-mediated synthesis where possible. Particular emphasis is on palladium and boron chemistry. For more details about our research, please visit the 'Research' page.
Latest papers:
Small-Molecule Induced Reactivation of Mutant p53 in Cancer Cells. Liu, X.; Wilcken, R.; Joerger, A.; Chuckowree, I.; Amin, J.; Spencer, J.; Fersht, A. Nucl. Ac. Res. 2013, accepted. Go to:
doi:10.1093/nar/gkt305
A Cyclodextrin-Capped Histone Deacetylase Inhibitor, Bioorg. Med. Chem. Lett. 2013, 23, 3346
Boron Medicinal Chemistry and Synthetic Aspects: A Mini-Editorial. Ahmet, J. T.; Spencer, J., Fut. Med. Chem., 2013, 5, 621.
Already out:
Amin, J.; Chuckowree, I.; Tizzard, G. J.; Coles, S. J.; Wang, M.; Bingham, J. P.; Hartley, J. A.; Spencer, J. Targeting Epidermal Growth Factor Receptor with Ferrocene-Based Kinase Inhibitors, Organometallics 2013, 32, 509.
Olefin cross-metathesis/Suzuki-Miyaura reactions on vinylphenylboronic acid pinacol esters. Baltus, C. B,; Chuckowree, I. S.; Press, N. J.; Day, I. J.; Coles, S. J.; Tizzard, G. J.; Spencer, J. Tetrahedron Lett. 2013, 54, 1211.
Cytotoxic Effects of Jay Amin Hydroxamic Acid (JAHA), a Ferrocene-Based Class I Histone Deacetylase Inhibitor, on Triple-Negative MDA-MB231 Breast Cancer Cells. Librizzi, M.; Longo, A.; Chiarelli, R.; Amin, J.; Spencer, J.; Luparello, C. Chem. Res. Tox. 2012, 25, 2608.
The Unexpected but Predictable Tetrazole Packing in Flexible 1-Benzyl-1H-Tetrazole. Spencer, J.; Patel, H.; Deadman, J. J.; Palmer, R. A.; Male, L.; Coles, S. J.; Uzoh, O. G.; Price, S. L. CrystEngComm 2012, 14, 6441.
Microwave-Mediated Suzuki–Miyaura Cross-Couplings of Thioether- and ortho-Substituted Methylphenylboronic Acid Esters. Baltus, C. B.; Press, N. J.; Spencer, J. Synlett 2012, 23, 2477.
Identification and Development of the 1,4-Benzodiazepin-2-one and Quinazoline-2,4-dione Scaffolds as Submicromolar Inhibitors of HAT. Clark, R. L.; Clements, C. J.; Barrett, M. P.; Mackay, S. P.; Rathnam , R. P.; Owusu-Dapaah, G.; Spencer, J.; Huggan, J. K. Bioorg. Med. Chem. 2012, 20, 6019.
Synthesis of a Biphenyl Library for Studies of Hydrogen Bonding in the Solid State. Baltus, C. B.; Press, N. J.; Antonijevic, M.D.; Tizzard, G. J.; Coles, S. J.; Spencer, J. Tetrahedron 2012, 68, 9272
Recent Advances in the Development of Selective CB2 Agonists as Promising Anti-Inflammatory Agents. Leleu-Chavain, N., Body-Malapel, M., Spencer, J., Chavatte, P. Desreumaux, P., Millet, R. Curr. Med. Chem. 2012, 19, 3457.
Synthesis of a 1,3,5-Benzotriazepine-2,4-dione Based Library. Chuckowree, I., Syed , M. A., Getti , G., Patel, A. P., Garner, H., Tizzard, G. J., Coles, S. J., Spencer, J. Tetrahedron Lett. 2012, 53, 3607.
The following organisations are thanked for funding our research:
