School of Life Sciences

Spencer Lab

Welcome to the Spencer group website.

The Spencer group conducts research on the interface of chemistry and medicinal chemistry, making use of transition metal catalysis and microwave-mediated synthesis where possible. Particular emphasis is on palladium and boron chemistry. For more details about our research, please visit the 'Research' page.

 

 

 

 

I)

 funding has been secured! Project starts 21-7-14.

II) New PhD:

 A Precompetitive Modular Peptidomimetic Toolkit for Targeting PPIs. EPSRC-AstraZeneca/Tocris sponsored. Starts Sept.

 

Papers

Synthesis of Hybrid Anticancer Agents Based on Kinase and Histone Deacetylase Inhibitors. Patel, H.; Chuckowree, I.; Coxhead, P. Guille, M.; Wang, M.; Zuckermann, A.;  Williams, R. S. B.;  Librizzi, M.; Paranal, R. N.;  Bradner, J. E.; Spencer, J. MedChemComm. 2014, DOI: 10.1039/c4md00211c,accepted, in press.

 

Multifunctional 8-Hydroxyquinoline-Appended Cyclodextrins as New Inhibitors of Metal-Induced Protein Aggregation. Oliveri, V.; Attanasio, F.; Puglisi, A.; Spencer, J.; Vecchio, G. Chem. Eur. J., 2014, 20, 8954-8964.

ACCEPTED AS BACK COVER FOR JOURNAL and highlighted on the ChemistryViews website:

http://www.chemistryviews.org/details/ezine/6193781/Inhibiting_Protein_Aggregation.html

                                                                                chemistry cover

Other highlights:

Incorporation by Coordination and Release of the Iron Chelator Drug Deferiprone from Zinc-Based Metal-Organic Frameworks. Burrows, A. D.;  Jurcic, M.; Keenan, L. L.; Lane, R. A.; Mahon, M. F.; Warren, M. R.; Nowell, H.; Paradowski, M.; Spencer, J. Chem. Comm. 2013, 49, 11260-11262.

Selected as a "hot article" 2013! (http://blogs.rsc.org/cc/2013/11/21/hot-chemcomm-november/)

 

 

Synthesis of Oxindole-Based Bioorganometallic Kinase Inhibitors Incorporating One or More Ferrocene Groups. Amin, J.;Chuckowree, I. S.; Wang, M.; Tizzard, G. J.; Coles, S. J.;  Spencer, J. Organometallics, 2013,32, 5818. 

New Cyclodextrin-Bearing 8-Hydroxyquinoline Ligands as Multifunctional Molecules.  Oliveri, V.; Puglisi, A.; Viale, M.;   Aiello, C.; Sgarlata, C.; Vecchio, G.; Clarke, J.; Milton, J.; Spencer, J.  Chem. Eur. J. 2013, 19, 13946.

Small-Molecule Induced Reactivation of Mutant p53 in Cancer Cells. Liu, X.; Wilcken, R.; Joerger, A.; Chuckowree, I.; Amin, J.; Spencer, J.; Fersht, A. Nucl. Ac. Res. 2013, 41, 6034.

Targeting Epidermal Growth Factor Receptor with Ferrocene-Based Kinase Inhibitors, Amin, J.; Chuckowree, I.; Tizzard, G. J.; Coles, S. J.; Wang, M.; Bingham, J. P.; Hartley, J. A.; Spencer, J. , Organometallics 2013, 32, 509.

 

The following organisations are thanked for kindly funding our research:

 

Oxford Nanopore Technologies RSC- Advancing the Chemical Sciences
Tocris - Bioscience
  Novartis  BP  Selcia Discoveryaz21

 

Contact

Dr John Spencer

Arundel Building
University of Sussex

T +44 1273 877374
E J.Spencer@sussex.ac.uk

Go to John Spencer's profile