Dr Andrew Penn
Glutamate receptors and excitatory synaptic transmission in health and disease
The theme of our research is understanding the role of glutamate receptor ion channels and excitatory synaptic transmission in health and disease. Specific questions include:
- How do human genetic mutations in glutamate receptor complexes modify excitatory synaptic transmission and cause disease?
- What factors govern the stability of glutamate receptors during excitatory synaptic plasticity?
- How methods can be developed to improve measurements of the spatiotemporal activity of excitatory synapses?
Depending on the question we use a range of techniques including computational modelling, tissue culture, patch-clamp electrophysiology and imaging. Projects will be adapted to suit individual background and preferences of the student.
- Penn AC, Zhang CL, Georges F, Royer L, Breillat C, Hosy E, Petersen JD, Humeau Y, Choquet D.(2017) Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors. Nature. 549(7672):384-388
- Hafner AS, Penn AC, Grillo-Bosch D, Retailleau N, Poujol C, Philippat A, Coussen F, Sainlos M, Opazo P, Choquet D. (2015) Lengthening of the Stargazin Cytoplasmic Tail Increases Synaptic Transmission by Promoting Interaction to Deeper Domains of PSD-95. Neuron. 86(2):475-89
- Constals A, Penn AC, Compans B, Toulmé E, Phillipat A, Marais S, Retailleau N, Hafner AS, Coussen F, Hosy E, Choquet D. (2015) Glutamate-induced AMPA receptor desensitization increases their mobility and modulates short-term plasticity through unbinding from Stargazin. Neuron. 85(4):787-803.
Visit the Penn Lab pages for more details and a full list of publications.