Client Protein activation by the Hsp90 Molecular Chaperone System

Protein kinase recruitment and activation by the HSP90-CDC37 system - funded by The Wellcome Trust

We are studying the structural and mechanistic basis for recruitment and activation of eukaryotic protein kinases by the HSP90-CDC37 system, using a combination of biochemical, bipohysical and structural techniques.

PIKK recruitment and activation by the R2TP-TTT system - funded by BBSRC

We are studying the structural and mechanistic basis for recruitment and activation of phoshatidylinositol kinase-like kinases (PIKKs) by the R2TP and TTT  systems, using a combination of biochemical, bipohysical and structural techniques.

Chaperone-targeted Ubiquitination - funded by The Wellcome Trust

We are studying the structural and biochemical basis for coupling of Hsp90 and Hsp70 to the ubiquitin-directed protein degradation system.