The Pearl Laboratory
CR-UK DNA Repair Enzymes Research Group

The Pearl Laboratory (PIs : Prof. Laurence Pearl FRS, Dr. Antony Oliver & Dr. Chris Prodromou) seeks to understand the structural basis for assembly, specificity and regulation of the multi-protein complexes involved in the recognition, repair and signalling of DNA damage, and in the chaperone-mediated stabilisation and activation of cellular signalling pathways.

These basic studies provide the means for discovery and development of novel small-molecule inhibitors with application as drugs for the treatment of cancer and other diseases.

Our work is funded by 


 

 
Cancer Research UK logo  Wellcome Investigator  MRC_GDSC_LOGO 

 

 

 

 

Pearl Lab wins prestigious Cancer Research UK Translational Cancer Research Prize 2013 for pioneering studies of the HSP90 molecular chaperone and the discovery of drugs that target its function in cancer - CR-UK Press Release  

Main Contacts

               Photo of Laurence Pearl
Professor Laurence H. Pearl FRS

Professor of Structural Biology and Head of School of Life Sciences

University of Sussex
John Maynard Smith Building
Falmer, Brighton, BN1 9QG

E Laurence.Pearl@sussex.ac.uk
T   +44 1273 876544
PA +44 1273 872699
Lab +44 1273 677512

Dr. Chrisostomos Prodromou

Senior Research Fellow

Dr. Antony W. Oliver

Senior Research Fellow

Independent Postdoc Fellow positions in Structural Biology

There are currently no vacant posts in the lab, but we are always interested to talk to ambitious young scientists who would like to pursue an independent Postdoctoral Fellowship in a world-class laboratory.

We are very happy to support applications for Sir Henry Wellcome Fellowships from outstanding researchers nearing completion of their PhDs. Contact Prof. Laurence Pearl FRS if you are interested.