The Pearl Laboratory
CR-UK DNA Repair Enzymes Research Group
The Pearl Laboratory (PIs : Prof. Laurence Pearl FRS, Dr. Antony Oliver & Dr. Chris Prodromou) seeks to understand the structural basis for assembly, specificity and regulation of the multi-protein complexes involved in the recognition, repair and signalling of DNA damage, and in the chaperone-mediated stabilisation and activation of cellular signalling pathways.
These basic studies provide the means for discovery and development of novel small-molecule inhibitors with application as drugs for the treatment of cancer and other diseases.
Our work is funded by
Pearl Lab wins prestigious Cancer Research UK Translational Cancer Research Prize 2013 for pioneering studies of the HSP90 molecular chaperone and the discovery of drugs that target its function in cancer - CR-UK Press Release