The Pearl Laboratory
CR-UK DNA Repair Enzymes Research Group
The Pearl Laboratory (PIs : Prof. Laurence Pearl FRS, Dr. Antony Oliver & Dr. Chris Prodromou) seeks to understand the structural basis for assembly, specificity and regulation of the multi-protein complexes involved in the recognition, repair and signalling of DNA damage, and in the chaperone-mediated stabilisation and activation of cellular signalling pathways.
These basic studies provide the means for discovery and development of novel small-molecule inhibitors with application as drugs for the treatment of cancer and other diseases.
Our work is funded by