Pearl Lab


Selections from more than 100 peer-reviewed publications 2001-2013

Professor Laurence Pearl

Qu, M., Rappas, M., Wardlaw,C.P., Garcia,V., Ren,J.-Y., Day,M., Carr,A.M., Oliver,A.W., Du,L.-L. and Pearl,L.H. (2013), ‘Phosphorylation-dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4TopBP1’, Mol. Cell, 51, 723–736.

Polier,S., Samant,R.S., Clarke,P.A., Workman,P., Prodromou,C. and Pearl,L.H. (2013), ‘ATP-competitive inhibitors of protein kinases block recruitment to the Hsp90-Cdc37 system’, Nature Chem Biol., 9, 307-312..

Ali.A.E.A., Timinszky,G., Arribas-Bosacoma,R., Kozlowski, M., Hassa,P.O., Hassler,M., Ladurner,A.G., Pearl,L.H. and Oliver,A.W. (2012) ‘The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks’, Nature Struct. Mol. Biol., 19, 685-692.

Garcas, F., Pearl, L.H. and Oliver, A.W. (2011) ‘The structural basis for substrate recognition by mammalian polynucleotide kinase 3’ phosphatase’, Mol Cell, 44, 385-396

Mollapour,M., Tsutsumi,S., Truman,A.W., Xu,W., Vaughan,C.K., Beebe,K., Konstantinova,A., Vourganti,S., Panaretou,B., Piper,P.W., Trepel,J.B., Prodromou,C., Pearl,L.H. and Neckers,L. (2011) 'Threonine 22 phosphorylation attenuates hsp90 interaction with cochaperones and affects its chaperone activity', Mol. Cell, 41, 672-681

Ali,M.M.U., Bagratuni,T., Davenport,E.L., Nowak,P.R., Silva-Santisteban,M.C., Hardcastle,A., McAndrews,C., Rowlands,M.G., Morgan,G.J., Aherne,W., Collins,I., Davies,F.E. and Pearl,L.H. (2011) ‘Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response’, EMBO J., 30, 894-905.

Zhang, M., Kadota, Y., Prodromou, C., Shirasu, K. and Pearl, L.H. (2010) ‘Structural basis for assembly of Hsp90-Sgt1-CHORD protein complexes: implications for chaperoning of NLR innate immunity receptors’, Mol. Cell, 39, 269-281

Oliver,A.W., Swift,S., Lord,C.J., AshworthA. and Pearl,L.H. (2009) 'Structural Basis for Recruitment of BRCA2 by PALB2', EMBO Rep., 10, 990-996.

Doré,A.S., Kilkenny,M.L., Rzechorzek,N.J. and Pearl,L.H. (2009) 'Crystal Structure of the Rad9-Rad1-Hus1 DNA Damage Checkpoint Complex - Implications for Clamp Loading and Regulation', Mol. Cell, 34, 735-745.

Vaughan,C.K., Mollapour,M., Smith,J.R., Truman,A., Hu,B., Good,V.M., Panaretou,B., Neckers,L., Clarke,P.A., Workman,P., Piper,P.W., Prodromou,C. and Pearl,L.H. (2008) 'Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37', Mol. Cell, 31, 886-895.

Vaughan,C.K., Gohlke,U., Sobot,F., Robinson,C.V., Ali,M.M.U., Prodromou,C., Saibil,H.R. and Pearl,L.H. (2006) 'Structure of an Hsp90 - Cdc37 - Cdk4 complex', Mol. Cell, 29, 697-707.

Oliver,A.W., Paul,A., Boxall,K.J., Barrie,S.E., Aherne,G.W., Garrett,M.D., Mittnacht,S. and Pearl,L.H. (2006) 'Trans-activation of the DNA damage-signalling protein kinase Chk2 by T-loop exchange'. EMBO J, 25, 3179-3190.

Spagnolo,L., Rivera-Calzada,A., Pearl,L.H. and Llorca,O. (2006) 'Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA double-strand break repair', Mol. Cell, 22, 511-519.

Ali,M.M.U., Roe,S.M., Vaughan.C.K., Meyer,P., Panaretou,B., Piper,P.W., Prodromou,C. and Pearl,L.H. (2006) 'Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex', Nature, 440, 1013-1017.

Zhang,M., Windheim,M., Roe,S.M., Peggie,M., Cohen,P., Prodromou,C. and Pearl,L.H. (2005) 'Chaperoned ubiquitylation - Crystal structures of the CHIP U-box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex', Mol. Cell, 20, 525-538.

Roe, S.M., M.M.U. Ali, Meyer, M., Vaughan, C.K., Panaretou, B., Piper, P.W., Prodromou, C. and Pearl, L.H. (2004) 'The mechanism of Hsp90 regulation by the protein kinase-specific co-chaperone p50cdc37', Cell, 116, 87-98.

Dajani, R., Fraser,E., Roe,S.M., Young,N., Good,V., Dale,T.C. and Pearl,L.H. (2001) 'Crystal structure of glycogen synthase kinase 3b : Structural basis for phosphate-primed substrate specificity and auto-inhibition', Cell 105, 721-732.

Publications with abstracts and links