Research Articles
Stok C, Tsaridou S, van den Tempel N, Everts M, Wierenga E, Bakker FJ, Kok Y, Alves IT, Jae LT, Raas MWD, Veld PJ Huis in 't, de Boer HR, Bhattacharya A, Karanika E, Warner H, Chen M, van de Kooij B, Dessapt J, Morsche L ter, Perepelkina P, Fradet-Turcotte A, Guryev V, Tromer EC, Chan KL, Fehrmann RSN, van Vugt MATM. FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics. Cell Reports (2023),42(7):112668. DOI: 10.1016/j.celrep.2023.112668
Mocanu C, Karanika E, Fernández-Casañas M, Herbert A, Olukoga T, Emir Ozgurses M, Chan KL. DNA replication is highly resilient and persistent under the challenge of mild replication stress. Cell Reports (2022), 39(3):110701. DOI: 10.1016/j.celrep.2022.110701
Mocanu C, Chan KL. Mind the replication gap. R Sco Open Sci (2021), DOI: 10.1098/rsos.201932
Mocanu C, Fernández-Casañas M, Herbert A, Olukoga T, Ozgurses ME, Chan KL. G2 DNA Synthesis is Essential to Safeguard Chromosome Integrity Under Replication Stress. Preprint available at SSRN: https://ssrn.com/abstract=3831464 or http://dx.doi.org/10.2139/ssrn.3831464
Addis Jones O, Tiwari A, Olukoga T, Herbert A, Chan KL. PLK1 facilitates chromosome biorientation by suppressing centromere disintegration driven by BLM-mediated unwinding and spindle pulling. Nature Communications (2019), 10(1):2861. DOI: 10.1038/s41467-019-10938-y
Addis Jones O, Tiwari A, Olukoga T, Herbert A, Chan KL. PLK1 protects centromeres from BLM-mediated disintegration to promote chromosome biorientation. Preprint available at BioRxiv(2018), DOI: https://doi.org/10.1101/498808
Srinivasan M*, Scheinost JC*, Petela NJ, Gligoris TG, Wissler M, Ogushi S, Collier JE, Voulgaris M, Kurze A, Chan KL, Hu B, Costanzo V, Nasmyth KA (*equal contribution). The Cohesin Ring Uses Its Hinge to Organize DNA Using Non-topological as well as Topological Mechanisms. Cell (2018), 173(6):1508-1519. DOI: 10.1016/j.cell.2018.04.015
Tiwari A, Addis Jones O, Chan KL. 53BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage process. Nature Communications (2018), 9(1):677. DOI: 10.1038/s41467-018-03098-y
Beckouët F*, Srinivasan M*, Roig MB*, Chan KL*, Scheinost JC, Batty P, Hu B, Petela N, Gligoris TG, Smith AC, Strmecki L, Rowland BD, Nasmyth K (*equal contribution). Releasing Activity Disengages Cohesin’s Smc3/Scc1 Interface in a Process Blocked by Acetylation. Molecular Cell (2016), 61(4):563-74. DOI: 10.1016/j.molcel.2016.01.026
Hu B, Petela N, Kurze A, Chan KL, Chapard C, Nasmyth K. Biological chromodynamics: a general method for measuring protein occupancy across the genome by calibrating ChIP-seq. Nucleic Acids Research (2015), 43(20):e132. DOI: 10.1093/nar/gkv670
Gligoris TG, Scheinost JC, Bürmann F, Petela N, Chan KL, Uluocak P, Beckouët F, Gruber S, Nasmyth K, Löwe J. Closing the cohesin ring: structure and function of its Smc3-kleisin interface. Science (2014), 346(6212): 963-7. DOI: 10.1126/science.1256917
Ying S*, Minocherhomji S*, Chan KL*, Palmai-Pallag T, Chu WK, Wass T, Mankouri HW, Liu Y, Hickson ID (*equal contribution). Mus81 promotes common fragile site expression. Nature Cell Biology (2013), 15(8): 1001-7. DOI: 10.1038/ncb2773
Chan KL, GligorisT, Upcher W, KatoY, Shirahige K, Nasmyth K, Beckouët F. Pds5 promotes and protects cohesin acetylation. PNAS (2013), 110(32): 13020-5. DOI: 10.1073/pnas.1306900110
Chan KL*, Roig MB*, Hu B*, Beckouët F, Metson J, Nasmyth K (*equal contribution). Cohesin’s DNA exit gate is distinct from its entrance gate and is regulated by acetylation. Cell (2012), 150(5): 961-974. DOI: 10.1016/j.cell.2012.07.028
Hu B, Itoh T, Mishra A, KatohY, Chan KL, UpcherW, GodleeC, RoigMB, Shirahige K, Nasmyth K. ATP hydrolysis is required for relocating cohesin from sites occupied by its Scc2/4 loading complex. Current Biology (2011), 21(1): 12-24. DOI: 10.1016/j.cub.2010.12.004
Lukas C, Savic V, Bekker-Jensen S, Doil C, Pedersen RS, Chan KL, Hickson ID, Bartek J, Lukas J. 53BP1 nuclear bodies form around DNA breaks generated by mitotic transmission of underreplicated chromosomes. Nature Cell Biology (2011), 13(3): 243-53. DOI: 10.1038/ncb2201
Chan KL, Palmai-Pallag T, Ying S, Hickson ID. Replication stress induces sister-chromatid bridging at fragile site loci in mitosis. Nature Cell Biology (2009),11(6): 753-60. DOI: 10.1038/ncb1882
Chan KL, North SP, Hickson ID. BLM helicase is required for faithful chromosome segregation and its localization defines a novel class of anaphase bridges. EMBO J (2007), 26(14): 3397-409. DOI: 10.1038/sj.emboj.7601777 (featured in Nature (2007), 448(7151): 228)
Wu L, Chan KL, Ralf C, Bernstein DA, Garcia PL, Bohr VA, Vindigni A, Janscak P, Keck JL, Hickson ID. The HRDC domain of BLM is required for the dissolution of double Holliday junctions. EMBO J (2005), 24(14): 2679-2687. DOI: 10.1038/sj.emboj.7600740
Yau TO, Chan CY, Chan KL, Lee MF, Wong CM, Fan ST, Ng IO. HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing. Oncogene (2005), 24(9): 1607-14. DOI: 10.1038/sj.onc.1208340
Chan KL, Guan XY, Ng IO. High-throughput tissue microarray analysis of c-Myc activation in chronic liver diseases and hepatocellular carcinoma. Human Pathology (2004), 35(11): 134-1331. DOI: 10.1016/j.humpath.2004.06.012 (Cover article)
Ng IO*, Chan KL, Shek WH, Lee JM, Fong DY, Lo CM, Fan ST (*corresponding author). High frequency of chimerism in transplanted livers. Hepatology (2003), 38(4): 989-998. DOI: 10.1053/jhep.2003.50395 (Cover article)
Chan KL, Lee JM, Guan XY, Fan ST, Ng IO. High-density allelotyping of chromosome 8p in hepatocellular carcinoma and clinicopathologic correlation. Cancer (2002), 94(12): 3179-85. DOI: 10.1002/cncr.10612
Law MY, To KY, Ho SH, Pang BCM, Wong LM, Wun HL, Yau SK, Chan KL. STR data for the PowerPlex 16 loci for the Chinese population in Hong Kong. Forensic Science International (2002), 129(1): 64-67. DOI: 10.1016/s0379-0738(02)00169-x
Reviews
Olukoga T, Fernández-Casañas M, Chan KL. Another string to the polo bow: a new mitotic role of PLK1 in centromere protection. Molecular & Cellular Oncology (2019), doi: https://doi.org/10.1080/23723556.2019.1658515 Review.
Fernández-Casañas M, Chan KL. The Unresolved Problem of DNA Bridging. Genes (2018).9(12).pii: E623. doi: 10.3390/genes9120623. Review.
Chan KL, Hickson ID. New insights into the formation and resolution of ultrafine anaphase bridges. Semin Cell Dev Biol (2011), 22(8): 906-12
Chan KL, Hickson ID. On the origins of ultra-fine anaphase bridges. Cell Cycle (2009), 8(19): 3065-6
Cheok CF, Bachrati CZ, Chan KL, Ralf C, Wu L, Hickson ID. Roles of the Bloom's syndrome helicase in the maintenance of genome stability. Biochem Soc Trans. (2005), 33(6): 1456-9