School of Life Sciences

Genome Damage and Stability Centre

looking for colonies of cells high performance image microscopy preparing for an experiment examining a reaction in a small tube plating out cells into dishes for incubation


The GDSC is a research centre investigating the responses of cells to
genome damage and their relationship to cancer and other aspects
of human disease

The centre provides a dynamic and collaborative environment for state-of-the-art research and is supported by a variety of funding agencies including the BBSRC, CR-UK, MRC and the Wellcome Trust.

For more information about individual group leaders, and the types of research taking place in the centre, please see 'Research groups' tab at the top of the page.


Job Opportunities

 Postdoctoral Research Fellow ref 2903

Closing date:  26 February 2018.  Applications must be received by midnight of the closing date. 
Expected interview date: 09 March 2018
Expected start date: As soon as available

Job description

The School of Life Sciences is at the forefront of research in the biological sciences in the UK, coming in the top 10 in the REF 2014.

The Genome Damage and Stability Centre is an internationally renowned research institute and is part of The School of Life Sciences (ranked in the top 10 in the REF 2014), and conducts research on cellular responses to DNA damage and their impact on genome instability and disease. We provide a stimulating and supportive environment and our expertise covers a range of experimental systems.

  • A Wellcome Trust and the Royal Society funded postdoctoral research position is available in the laboratory of Dr Kok-Lung (Chris) in Genome Damage and Stability Centre until 31st of July 2019 in the first instance.
  • Candidates are expected to investigate the interplay of DNA replication and mitosis to understand the process of chromosome segregation.
  • The successful applicant will be conscientious, hardworking, and will have experience of working within a multidisciplinary team. Applicants must have a relevant PhD, proven experience in mammalian cell biology, and preferably proven skills in molecular biology and imaging.
  • An overview of research in the Chan lab can be found here. Applications, including full CV, should be sent to, and further information can be obtained informally from Kok-Lung (Chris) Chan; E-mail



PhD Studentship in Genome Stability- Elucidating the role and mechanism of a novel DNA maintanance pathway

Project Description

Cells possess a myriad of DNA maintanance pathways that ensure genome stability. In recent years, it has been reported that members of the Primase-Polymerase (Prim-Pol) family play crucial roles in repairing and tolerating DNA damage in cells. The aim of this project is to study the role and mechanism of a recently discovered Prim-Pol related pathway. Specifically, we would like to identify the components of this Prim-Pol complex and define it’s modus operandi by reconstituting this repair / replication process in vitro. Applicants will receive advanced training in biochemical, biophysical and molecular biology techniques to enable them to study the molecular interactions and enzymatic mechanism of this protein complex with the goal of better defining it’s key role(s) in DNA repair / replication processes. 
The successful applicant will join the Genome Damage and Stability Centre, an internationally renowned Institute carrying out research on the response of cells to DNA damage and genome instability. We provide a stimulating and supportive research and training environment. Our expertise covers a wide range of experimental systems.


How to apply: 
Apply for PhD in Genome Stability (2017-18 entry) using Mention name of supervisor in “suggested supervisor” section. In funding mention sponsored or seeking funding. In Award details mention School of Life Sciences funded studentship. Include brief statement of interest (up to 2 pages), CV, two academic references, UG/PG transcripts, IELTS/TOEFL results if residing in EU. 

For further queries please contact: Professor Aidan Doherty ()


31st March, 2018


Employment opportunites may be found at



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