Genome Damage and Stability Centre


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Research Fellow Ref: 6845

School/department: School of Life Sciences, Genome Damage and Stability Centre
Hours: full time or part time hours considered up to a maximum of 1 FTE, core hours 10am-4pm. Requests for flexible working options will be considered (subject to business need).
Contract: fixed term until 31 December 2024
Reference: 6845
Salary: starting at £34,304 to £40,927 per annum, pro rata if part time
Placed on: 24 September 2021 
Closing date: 22 October 2021. Applications must be received by midnight of the closing date.
Expected start date: 1 January 2021

Job description

The School of Life Sciences is at the forefront of research in the biological sciences in the UK, coming in the top 10 in the REF 2014.

Based in the School of Life Sciences, the Genome Damage and Stability Centre  (, is an internationally renowned Institute carrying out research on the response of cells to DNA damage, genome instability and its relationship to disease. We provide a stimulating and supportive environment and our expertise covers a range of experimental systems.

  • A postdoctoral fellowship, funded by a Catalyst Award from  Breast Cancer Now, is available starting Jan 1st 2022 to analyse a new signalling pathway that synergises with Cdk4/6 and could be exploited therapeutically in triple negative breast cancer cells.
  • Cdk4/6 inhibitors such as Pfizer’s Palbociclib have been successfully employed to treat ER positive breast cancer. However, the most aggressive types of breast cancer do not respond well to Palbociclib and even cancer types that do respond often develop resistance to the treatment. This necessitates new combinatorial strategies to treat this pathway more effectively. This project will investigate a novel pathway that acts in parallel to Cdk4/6 in early G1 phase to uncover basic mechanisms and design therapeutic strategies for triple negative breast cancer patients.
  • Candidates must have experience in human cell culture, CRISPR-Cas9-mediated genome editing and be familiar with basic data science approaches (Python, Matlab). They should have a strong background in cell cycle control with evidence of independence and productivity (first authorship publication). This post is funded for 3 years.

The University is committed to equality and valuing diversity, and applications are particularly welcomed from women and black and minority ethnic candidates, who are under-represented in academic posts in Science, Technology, Engineering, Medicine and Mathematics (STEMM) at Sussex.

The School of Life Sciences is committed to increasing the diversity of its staff and providing an inclusive working environment. The School currently holds an Athena SWAN Silver Award, has developed a Race Equity Action Plan and hosts an active Equality, Diversity and Inclusion working group.

Applications are particularly welcomed from Black and minority ethnic candidates, and women, trans and non-binary candidates, who are under-represented in the School of Life Sciences.

Applications to posts from candidates who wish to work part-time or as job-sharers are welcome.

The University offers various schemes to provide real benefits to parents, these can be found at Family Friendly Policies

Potential candidates are strongly encouraged to make informal contact with Dr. Helfrid Hochegger; before applying.

The University of Sussex values the diversity of its staff and students and we welcome applicants from all backgrounds.

You can find out more about our values and our EDI Strategy,  Inclusive Sussex, on our webpages.

Download job description and person specification Ref 6845 [PDF 223.13KB]

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