Publications

H-index 40

 

Selected publications (since 2008)

  1. K. L. Morris, L. Chen, A. Rodger, D. J. Adams and L. C. Serpell, Soft matter, 2015. (In press)
  2. S. Kaltofen, C. Li, P. Huang, L. C. Serpell, A. Barth and I. Andre, Journal of molecular biology, 2014. (In Press)
  3. D. W. Sanders, S. K. Kaufman, S. L. DeVos, A. M. Sharma, H. Mirbaha, A. Li, S. J. Barker, A. C. Foley, J. R. Thorpe, L. C. Serpell, T. M. Miller, L. T. Grinberg, W. W. Seeley and M. I. Diamond, Neuron, 2014, 82, 1271-1288.
  4. P. P. Mangione, R. Porcari, J. D. Gillmore, P. Pucci, M. Monti, M. Porcari, S. Giorgetti, L. Marchese, S. Raimondi, L. C. Serpell, W. Chen, A. Relini, J. Marcoux, I. R. Clatworthy, G. W. Taylor, G. A. Tennent, C. V. Robinson, P. N. Hawkins, M. Stoppini, S. P. Wood, M. B. Pepys and V. Bellotti, Proceedings of the National Academy of Sciences of the United States of America, 2014, 111, 1539-1544.
  5. K. E. Marshall, R. Marchante, W. F. Xue and L. C. Serpell, Prion, 2014, 8.
  6. C. Colquhoun, E. R. Draper, E. G. Eden, B. N. Cattoz, K. L. Morris, L. Chen, T. O. McDonald, A. E. Terry, P. C. Griffiths, L. C. Serpell and D. J. Adams, Nanoscale, 2014, 6, 13719-13725.
  7. Xu C; Liu R, Mehta A, Guerrero-Ferreira R,Wright E, Dunin-Horkawicz S, Morris K, Serpell L, Zuo, X, Wall J, Conticello V. (2013) J. Am. Chem. Soc. Rational Design of Helical Nanotubes from Self-assembly of Coiled-coil Lock Washers. In press.
  8. Kyle L. Morris, Lin Chen, Jaclyn Raeburn, Owen R. Sellick, Pepa Cotanda,Alison Paul, Peter C. Griffiths, Stephen M. King, Rachel O’Reilly, Louise C. Serpell,* and Dave J. Adams*. *Joint corresponding authors. Chemically Programmed Self-Sorting of Gelator Networks. Nature Communications 4, 1480
  9. 2. Morris KL, Rodger A, Hicks MR, Debulpaep M, Schymkowitz J, Rousseau F, Serpell LC. Exploring the sequence-structure relationship for amyloid peptides. Biochem J. 2012 Dec 20. [Epub ahead of print]
  10. 3. Kyle L. Morris, Shahin Zibaee, Lin Chen, Michel Goedert, Pawel Sikorski, Louise C. Serpell. The Structure of Cross-ß Tapes and Tubes Formed by an Octapeptide, αSß1. Angewandte Chemie. (Early View).
  11. 4. Houton, K.A., Morris, K.L*., Chen, L., Schmidtmann, M., Jones, J.T.A., Serpell, L.C., Lloyd, G.O., Adams, D.J. (2012) On crystal versus fiber formation in dipeptide hydrogelator systems Langmuir 28 (9797-9806 
  12. 5. Serpell LC. Encylopedia for Biophysics 2013 , “X-ray fibre diffraction”, Pub. Springer ISBN 978-3-642-16711-9
  13. 6. Nicolas M. Perney, Lucy Braddick, Martin Jurna, Erik T. Garbacik, Herman L. Offerhaus, Louise C. Serpell, Ewan Blanch, Lindy Holden-Dye, William S. Brocklesby, Tracy Melvin. (2012) Polyglutamine aggregate structure in vitro and in vivo; new avenues for Coherent Anti-Stokes Raman Scattering Microscopy, PLOSone 7, e40536
  14. 7. Morris K.*, Serpell, LC. (2012). From molecular to supramolecular amyloid structures: contributions from fiber diffraction and electron microscopy. In “Amyloid fibrils”. Daniel Otzen Ed. Pub. Wiley (In press)
  15. 8. Morris K*., Serpell, LC. (2012) X-ray Fibre Diffraction Studies of Amyloid Fibrils, Amyloid Proteins: Methods and Protocols, Einar M. Sigurdsson et al. (eds.), Methods in Molecular Biology, vol. 849, 121-135
  16. 9. Pauwels K, Williams TL*, Morris KL*, Jonckheere W, Vandersteen A, Kelly G, Schymkowitz J, Rousseau F, Pastore A, Serpell LC, et al. (2012) The structural basis for increased toxicity of pathological Abeta42:Abeta40 ratios in Alzheimer's disease. The Journal of biological chemistry, 287, 5650-5660
  17. 10. Ye Z, Bayron Poueymiroy D, Aguilera JJ, Srinivasan S, Wang Y, Serpell LC, Colón W. (2011) Inflammation Protein SAA2.2 Spontaneously Forms Marginally Stable Amyloid Fibrils at Physiological Temperature. Biochemistry. 50, 9184-91
  18. 11. Soura V,* Stewart Parker M*, Willliams TL*, Ratnayaka A, Atherton J, Gorringe K,* Tuffin J*, Darwent E*, Rambaran R*, Klein W, Lacor P, Staras K, Thorpe JR, Serpell LC. (2012) Visualisation of colocalisation in Ab42-administered neuroblastoma cells reveals lysosome damage and autophagosome accumulation related to cell death. Biochem J. 441 579-90.
  19. 12. Lin Chen, Guillaume Pont, Kyle Morris*, Gudrun Lotze, Adam Squires, Louise C. Serpell and Dave J. Adams (2011). Salt-induced Hydrogelation of Functionalised-Dipeptides at high pH. ChemComm. 47 (44), 12071 - 12073
  20. 13. Williams TL*, Johnson BRG, Urbanc B, Jenkins ATA, Connell SDA, Serpell LC. (2011). Alzheimer's Aβ42 oligomers but not fibrils simultaneously bind to and cause damage to ganglioside containing lipid membranes. Biochemical Journal. 439, 67-77
  21. 14. Williams TL*, Serpell LC (2011). Membrane and surface interactions of the Alzheimer's Aß peptide: insights into the mechanism of cytotoxicity. FEBS J. 78, 3905-17
  22. 15. Marshall KE*, Morris KL*, Charlton D*, O'Reilly N, Lewis L, Walden H, Serpell LC. (2011) Hydrophobic, aromatic and electrostatic interactions play a central role in amyloid fibril formation. Biochemistry. 50, 2061-71
  23. 16. Liu B, Moloney A, Meehan S, Morris K,* Thomas SE, Serpell LC, Hider R, Marciniak SJ, Lomas DA, Crowther DC.(2011) Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation.J Biol Chem. 286, 4248-56
  24. 17. Williams T*, Day, I, Serpell LC. (2010) The Effect of Alzheimer’s Aβ Aggregation state on the Permeation of Biomimetic Lipid Vesicles. Langmuir, 26, 17260-8
  25. 18. Zibaee S*, Fraser G, Jakes R, Owen D, Serpell LC, R. Crowther A, Goedert M. (2010) Human beta-Synuclein rendered fibrillogenic by designed mutations. J Biol. Chem. 285, 38555-67
  26. 19. Adams, D, Morris, K*, Chen, L, Serpell, L, Bacsa, J, Day, G. The delicate balance between gelation and crystallisation: structural and computational investigations (2010) Soft matter 6, 4144-4156
  27. 20. Chen, L, Revel, S, Morris K*, Spiller DG, Serpell LC and Adams DJ. (2010). Low molecular weight gelator–dextran composites. Chem. Commun., 46, 6738-6740
  28. 21. Morris KM*, Serpell LC. From natural to designer self-assembling biomaterials: the structural characterisation of fibrous proteins using fibre diffraction. Chemical society reviews 39, 3445-3453 
  29. 22. Andersen CB, Hicks MR, Vetri V. Vandahl B, Rahbek-Nielsen H, Thøgersen H, Thøgersen IB, Enghild JJ, Serpell LC, Rischel C, Otzen D E. (2010) Glucagon fibril polymorphism reflects differences in protofilament backbone structure. J Mol. Biol 397, 932-46 
  30. 23. Marshall M*, Serpell LC. (2010) Fibres, crystals and polymorphism: the structural promiscuity of amyloidogenic peptides. Soft Matter (invited review) 6, 2110 - 2114
  31. 24. Maurer-Stroh, S, Debulpaep, M, Kuemmerer, N, Lopez de la Paz, M, Martins, IC, Morris, KL*, Reumers, J, Copland, A*, Serpell, L, Serrano, L, Rousseau, F, Schymkowitz, JWH (2010) An exploration of the sequence determinants of amyloid formation and the development of the Waltz prediction algorithm. Nature methods 7, 237-42
  32. 25. Glocking S & Serpell LC. (2010) A new species of aplanosporic Haptoglossa, H. beakesii, with vesiculate spore release. Botany, 88, 93-101 
  33. 26. Marshall K*, Hicks M, Williams TL*, Rodger A, Dafforn T, Serpell LC. A fibre to crystal switch in the Sup35 yeast prion fragment, GNNQQNY. (2010) Biophysical J 98, 330-338
  34. 27. Lin Chen, Kyle Morris*, Andrea Laybourn, David Elias, Matthew R. Hicks, Alison Rodger, Louise Serpell and Dave J. Adams (2010). The Self-Assembly Mechanism for a Naphthalene-Dipeptide Leading to Hydrogelation. Langmuir 6, 5232-42. 
  35. 28. Jahn, T. Makin OS*, Morris K*, Marshall KM*, Tian, P*, Sikorski P, Serpell LC. (2010) J. Mol. Biol. The common architecture of cross-beta amyloid, 395, 717-727 
  36. 29. Maurstad G, Prass M, Serpell LC, Sikorski P. (2009) Dehydration stability of amyloid fibrils studied by AFM. Eur. J. Biophys. 38, 1135-1140
  37. 30. Marshall, KM* & Serpell, L.C. (2009) Insights into the structure of amyloid fibrils (invited review). Open Biology 2, 185-192
  38. 31. Banwell, EF, Abelardo, ES, Adams, DJ, Birchall,MA, Corrigan, A, Donald, AM, Kirkland,M Serpell,LC,. Butler, MF and Woolfson, DN. (2009) Rational design and application of alpha-helical peptide hydrogels. Nature Materials. 8, 596-600
  39. 32. Tamamis,P, Adler-Abramovich, L, Reches, M, Marshall, K*, Sikorski, P, Serpell, L, Gazit, E and Archontis, G (2009). Self-Assembly of Phenylalanine Oligopeptides: Insights from Experiments and Molecular Dynamics Simulations in Implicit Solvent. Biophys. J. 96, 5020-5029
  40. 33. Marshall, K.M.* & Serpell, L.C. (2009) The structural integrity of beta-sheet assembly (invited review). Biochemical transactions 37, 671–676
  41. 34. Benjamin M. Bulheller,, Alison Rodger, Matthew R. Hicks, Timothy R. Dafforn, Louise C. Serpell, Karen Marshall*, Elizabeth H. C. Bromley Patrick J. S. King, Kevin J. Channon, Derek N. Woolfson, and Jonathan D. Hirst. 29 Linear Dichroism of Some Prototypical Proteins. J. Am. Chem. Soc. 131, 13305-13314
  42. 35. Madine J, Copland A* Serpell, L, Middleton D (2009) Cross-β spine architecture of fibrils formed by the amyloidogenic segment NFGSVQFV of medin from solid-state NMR and X-ray fibre diffraction measurements. Biochemistry. 48, 3089-3099
  43. 36. Rambaran RN, Serpell LC. (2008) Amyloid fibrils: Abnormal protein assembly. Book chapter “Fibrous proteins” Ed. T Scheibel. Landes Bioscience
  44. 37. Steinmetz MO, Gratin Z, Verei R, Ciani B, Stromer T, Green J, Tittman P, Schultze-Brise C, Gross H, van Gunsteren WF, Meier BH, Serpell LC, Muller SA, Kammerer RA. (2008) Atomic model of de novo designed ccb-Met amyloid-like fibrils. J. Mol. Biol. 376, 898-912.
  45. 38. Fukuma T, Mostaert, AS, Serpell LC, Jarvis JP. (2008) Revealing molecular-level surface structure of amyloid fibrils in liquid by means of frequency modulation atomic force microscopy. Nanotechnology 19, 384010-384016.
  46. 39. Madine J, Jack E, Stockley P, Radford S, Serpell L, Middleton D. (2008) Structural insights into the polymorphism of amyloid-like fibrils formed by region 20-29 of amylin revealed by solid-state NMR and X-ray fibre diffraction. J. Am. Chem. Soc. 130, 14990-15001.
  47. 40. Anja Hagenau, Holger A. Scheidt, Louise Serpell, Daniel Huster, Thomas Scheibel*.(2008) Structural Analysis of Proteinaceous Components in Byssal Threads of the Mussel Mytilus galloprovincialis. Macromol. Biosci. 9, 162-168.
  48. 41. Rambaran, R.N.* & Serpell, L.C. (2008) Amyloid fibrils: abnormal protein assembly. Prion 2, 112-7.