The Research Interests Of The Biochemistry And Molecular Biology Group Center On Proteins And The Genes That Encode Them.
The group is an integral part of the School of Life Sciences, with thirteen research groups and three research facilities, providing a dynamic and collaborative environment for carrying out state-of-the-art research.
Principal investigators and labs
Subject Chair: Alison Sinclair.
Dr John Armstrong
We are studying how a much-studied single-celled organism, fission yeast, switches to a much more complex growth form of elaborate multicellular filaments. This provides an unprecedented opportunity to understand how eukaryotic cells differentiate at the molecular level, and may ultimatley lead to new ways to treat fungal infections, currently a major problem in medicine and agriculture.
For more information visit the Armstrong lab web site
Professor John Atack
The Atack lab focus on the development of novel drugs directed against a variety of oncology and neuroscience drug targets. As regards oncology, we work with our key collaborators at the University of Sussex Genome Damage and Stability Centre to identify and develop drugs directed against enzymes important in DNA damage repair pathways that are implicated in cancer. Within the neuroscience area, we work on drugs directed not only against neurotransmitter systems in the brain, and which are designed to provide symptomatic relief, but also pathways involved in neurodegenerative processes.
For more information please visit the Translational Drug Discovery web site
Dr Neil Crickmore - Bacillus thuringiensis BT Lab
Research in the Crickmore lab is based upon the bacterium Bacillus thuringiensis and its insecticidal toxins. We are interesting in discovering and developing novel biological insecticides and in studying the interaction between these and their insect targets. We also use this bacterium and its host as a model system for studying a variety of ecological, physiological, biochemical and genetic processes.
For more information visit the Bacillus thuringiensis BT Lab website.
Professor Tony Moore
My laboratory's research interests are focussed upon the structure and function of the alternative oxidases in plants and parasites. In particular we are interested in how the structure of this important but enigmatic protein influences its function in plants and parasites. Although this protein has been known for over 100 years still relatively little is known about its mechanism of action or physiological significance. To this end we are crystallising mutant and wild-type forms of the protein from both plants and human pathogens which will provide structural and mechanistic clues as to its function in vivo.
For more information visit the Moore Lab website.
Professor Simon Morley
We are investigating the signalling pathways regulating mRNA utilisation in eukaryotic cells during proliferation and differentiation. Our main focus is on the initiation factor complex, eIF4F, and its regulated assembly during different phases of the cell cycle. We are also developing tools to investigate localised protein synthesis in cells maintained in 2D and 3D culture. Although the regulation of protein synthesis is fundamental to cell growth and survival, relatively little is actually known about the role of phosphorylation of translation initiation factors in modulating this process.
For more information visit the Morley Lab website.
Dr Mark Paget
We study the molecular biology of gene expression in bacteria with focus on the actinomycete family of bacteria. The large actinomycete family are Gram-postive bacteria with a high content of G+C in their DNA, and includes many bacteria of medical and indutrial importance. For example, the Streptomyces genus are famous as the source of most clinically useful antibiotics, whereas the major human pathogen Mycobacterium tuberculosis kills more people world-wide than any other single infectious agent. Our primary model organism is the genetically and physiologically well-characterised Streptomyces coelicolor. We have recently widened our interests to include the control of fermentation in the bioethanol-producing thermophile Geobacillus thermoglucosidasius.
For more information visit the Paget Lab website
Dr Roger Phillips
My research is focused on exploiting new optical tools for the study of molecular function in cells.
For more information please visit the Light Microscopy facility page.
Dr Chris Prodromou
I work as part of the Pearl Laboratory, managing the day-to-day activities of the Wellcome Trust Molecular Chaperone Group. We seek to understand the structural basis for the matuaration and activation of diverse array of client proteins and the interplay between the Hsp90 chaperone machine and its associated complexes.
For more information visit the Prodromou Lab website.
Dr Mark Roe
The research of the lab is geared towards the understanding of structure and mechanism of proteins and protein complexes in collaboration with other groups both in the university and from elsewhere.
For more information visit the Roe Lab website.
Professor Louise Serpell
The Serpell Group work on the structure and function of amyloidogenic proteins using a range of biophysical and imaging techniques
For more information visit the Serpell Lab website.
Professor Alison Sinclair
Cancer virus interactions with host cells
Epstein Barr virus
EBV is the causative agent of Burkitt's Lymphoma, Hodgkin's Disease, Nasopharyngeal Carcimoma and Lymphoproliferative diseases in immunocompromised people. By adulthood, most people are infected with EBV and the virus persists in the body for life.
Dr Sinclair's research research group investigate the interactions between EBV and host cells that direct whether the virus establishes latency and promotes cancer development or undergoes lytic replication - destroying the cell. Members of the group can be found under the "people" section.
For more information visit the Sinclair Lab website.
Dr Mike Titheradge
For more information on my Dr Titheradge's specialist interests and the modules he teaches please look at his profile
Dr Michelle West
The research in our laboratory is focussed on deciphering the mechanisms involved in B-cell transformation by the cancer-associated herpesvirus, Epstein-Barr virus (EBV).
For more information visit the West Lab website