Lagnado Lab


Preprints and some recent papers



Tristan Heintz, Antonio Hinojosa, Leon Lagnado (2020).  Opposing forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits and gated by locomotion. bioRxivdoi:

Daniel SaskaPaul PichlerChen QianChrysia PegasiouChristopher Laurie BuckleyLeon Lagnado. μSPIM: A Software Platform for Selective Plane Illumination Microscopy. bioRxiv doi:

Jose Moya-Diaz, Ben James, Leon Lagnado (2020). Modulation of the vesicle code transmitting the visual signal in the retina. bioRxiv doi:


Paul Pichler and Leon Lagnado (2020).  Motor behaviour selectively inhibits hair cells activated by forward motion in the lateral line of Zebrafish.  Current Biology30(1): 150-157.

Brebner LS, Ziminski JJ, Margetts-Smith G, Sieburg MC, Reeve HM, Nowotny T, Hirrlinger J, Heintz TG, Lagnado L, Kato S, Kobayashi K, Ramsey LA, Hall CN, Crombag HS, Koya E. (2020). The emergence of a stable neuronal ensemble from a wider pool of activated neurons in the dorsal medial prefrontal cortex during appetitive learning in mice. Journal of Neuroscience, .

Schröder S, Steinmetz NA, Krumin M, Pachitariu M, Rizzi M, Lagnado L, Harris KD, Carandini M. (2020). Arousal Modulates Retinal Output. Neuron. May 13:S0896-6273(20)30318-4. doi: 10.1016/j.neuron.2020.04.026. Online ahead of print.

Thomas Ryan, Antonio Hinojosa, Rozan Vroman, Christoforos Papasavvas, Leon Lagnado (2020).  Correction of z-motion artefacts to allow population imaging of synaptic activity in behaving mice.  Journal of Physiology598(10):1809-1827. doi: 10.1113/JP278957.

James, B Darnet L, Moya-Diaz J, Seibel S-H, & Lagnado L. (2019). An amplitude code transmits information at a visual synapse. Nature Neuroscience, 22(7):1140-1147.

Johnston, J., Seibel, S-H., Darnet, L., Renninger, S., Orger, M. & Lagnado, L. (2019). A Retinal Circuit Generating a Dynamic Predictive Code for Oriented Features. Neuron102(6):1211-1222.

Pichler P, Lagnado L. (2019). The transfer characteristics of hair cells encoding mechanical stimuli in the lateral line of zebrafishJournal of Neuroscience 39(1) :112-124.

C Schröder, B James, L Lagnado, P Berens. (2019).  Approximate Bayesian Inference for a Mechanistic Model of Vesicle Release at a Ribbon Synapse. Advances in Neural Information Processing Systems 32, 7068-7078.

Okawa H, Yu WQ, Matti U, Schwarz K, Odermatt B, Zhong H, Tsukamoto Y, Lagnado L, Rieke F, Schmitz F, Wong ROL. (2019).  Dynamic assembly of ribbon synapses and circuit maintenance in a vertebrate sensory system. Nature Communications10(1):2167.

Wan-Qing Yu, Rana N. El-Danaf, Haruhisa Okawa, Justin M. Pacholec, Ulf Matti, Karin Schwarz, Benjamin Odermatt, Felice A. Dunn, Leon Lagnado, Frank Schmitz, Andrew D. Huberman and Rachel O.L. Wong (2018).  Synaptic convergence patterns onto retinal ganglion cells are preserved despite topographic variation in pre- and postsynaptic territories.  Cell Reports 25(8):2017-2026.

Tom Baden, Ben James, Maxime JY Zimmermann, Philipp Bartel, Dorieke M Grijseels, Leon Lagnado, Miguel Maravall (2018).  Spikeling: A low-cost hardware implementation of a spiking neuron for neuroscience teaching and outreach. PLoS Biology, 16(10):e2006760.

Rosa JM, Ruehle S, Ding H, and Lagnado L. (2016). Crossover Inhibition Generates Sustained Visual Responses in the Inner Retina. Neuron, 90(2):308-19.

Lagnado L and Schmitz F. (2015). Ribbon synapses and visual processing in the retina.  Annual Reviews of Vision Science, 1:235-262.

Johnston J and Lagnado L. (2015). General features of the retinal connectome determine the computation of motion anticipation. eLife, 4:06250.

Baden T, Nikolaev A, Esposti F, Dreosti E, Odermatt B and Lagnado, L. (2014). A synaptic mechanism for temporal filtering of visual signals. PLoS Biology, 12: e1001972.

Johnston J,  Ding H,  Seibel S-H, Esposti F and Lagnado L. (2014). Rapid mapping of visual receptive fields by filtered back projection: application to multi-neuronal electrophysiology and imaging. Journal of Physiology, 592: 4839-4854.

Esposti F, Johnston J, Rosa J, Leung K-M and Lagnado L. (2013). Olfactory stimulation selectively modulates the OFF pathway in the zebrafish retina. Neuron, 79:97-110.

Nikolaev A, Leung K-M, Odermatt B and Lagnado L. (2013). Synaptic mechanisms of adaptation and sensitization in the retina. Nature Neuroscience, 16: 934-941.

Akerboom J, Chen TW, Wardill TJ, Tian L, Marvin JS, Mutlu S, Calderón NC, Esposti F, Borghuis BG, Sun XR, Gordus A, Orger MB, Portugues R, Engert F, Macklin JJ, Filosa A, Aggarwal A, Kerr RA, Takagi R, Kracun S, Shigetomi E, Khakh BS, Baier H, Lagnado L, Wang SS, Bargmann CI, Kimmel BE, Jayaraman V, Svoboda K, Kim DS, Schreiter ER, Looger LL. Optimization of a GCaMP calcium indicator for neural activity imaging.J Neurosci. 2012 Oct 3;32(40):13819-40. 
Johnston J and Lagnado L. (2012). What the fish’s eye tells the fish’s brain. Neuron, 76: 257-259.

Odermatt B, Nikolaev A and Lagnado L. (2012). Encoding of luminance and contrast by linear and non-linear synapses in the retina. Neuron73: 758-773.

Baden T, Esposti F, Nikolaev A and Lagnado L. (2011). Spikes in retinal bipolar cells phase-lock to visual stimuli with millisecond precision. Current Biology, 21: 1859-1869.

Dreosti E, Esposti F, Baden T and Lagnado L. (2011). In vivo evidence that retinal bipolar cells generate spikes modulated by light. Nature Neuroscience, 14: 951-952.


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More Publications

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