Lagnado Lab

Welcome to the Lagnado Lab

We are investigating two neural circuits that are involved in the processing of visual information - the retina and the visual cortex. The question that guides our research is “how do synapses in the visual system contribute to the extraction and transfer the information in a visual stimulus?”.

How do synaptic machines function within neural circuits?  We have developed fluorescent reporter proteins by which the electrical activation of synapses and the resulting output - vesicle fusion – can be monitored across hundreds of neurons simultaneously.  By applying multiphoton microcopy to transgenic zebrafish and mice expressing these reporters we can observe synaptic activity in vivo as the visual system responds to stimuli.  Most of our work has investigated the retina of zebrafish, but we are now also working on the synaptic basis of computations in the visual cortex of mice.  Our general aim is to understand how the short-term platicity of synapses contributes to the control of tuning and responsitivity within these circuits.  We are particularly interested in “network adaptation” - changes in the way that visual stimuli are processed by the neural circuit according to the recent history of activity.

Our approach to investigating these questions involves a combination of techniques, including electrophysiology, molecular biology, multiphoton imaging and computational modelling.  


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Prof. Leon Lagnado FMedSci

Professor of Neuroscience

School of Life Sciences
University of Sussex
Brighton BN1 9QG

Tel: 01273 877431



Post-doctoral Researchers

Positions are currently available and enquiries are welcome.  These positions will be funded by the Wellcome Trust and the BBSRC.  If you are interested in the questions that we are asking and have experience in one or more of the techniques that we use, please contact Leon Lagnado with a CV and a short description of your experience in research.


Ph.D Studentship

A studentship is available as part of an "Innovative Training Network (ITN)" funded by the European Commission's Horizon 2020 programme.  The title of the network is "In the eye of the observer: Visual processing at the heart of the retina". More information about the project is available here and here.  If you are interested in applying please contact Leon Lagnado with a CV. Note that applicants must NOT have resided in the UK for more than 12 months in the last 3 years.