A microRNA that controls the emergence of embryonic movement eLife 13:RP95209

A novel post-developmental role of the Hox genes underlies normal adult behaviour Proc Natl Acad Sci U S A 119(49):e2209531119. doi: 10.1073/pnas.2209531119. Epub 2022 Dec 1. PMID: 36454751

Klann, M., Issa, A.R., Pinho, S. and Alonso, C.R. (2021) microRNA-dependent control of sensory neuron function regulates posture behaviour in Drosophila J Neurosci. 41(40):8297-8308. doi: 10.1523/JNEUROSCI.0081-21.2021.

Loveless, J., Garner, A., Issa, A.R., Roberts, R., Webb, B., Prieto-Godino, L.L., Ohyama, T. and Alonso, C.R. (2020) A physical theory of movement in small animals BioRxiv doi:

Klann, M., Issa, A.R., Pinho, S. and Alonso, C.R. (2020) microRNA-dependent control of sensory neuron function regulates posture behaviour in Drosophila BioRxiv doi:

Issa, A.R., Picao-Osorio, J., Rito, N., Chiappe, M.E. and Alonso, C.R. (2019) A Single MicroRNA-Hox Gene Module Controls Equivalent Movements in Biomechanically Distinct Forms of Drosophila, Current Biology pii: S0960-9822(19)30842-5. doi: 10.1016/j.cub.2019.06.082. [Epub ahead of print](published online 18 July 2019)

Kaschula R., Pinho, S. and Alonso, C.R. (2018) microRNA-dependent regulation of Hox gene expression sculpts fine-grain morphological patterns in a Drosophila appendage, Development pii: dev.161133. doi: 10.1242/dev.161133 (published online 24 August 2018)

Picao-Osorio J, Lago-Baldaia I, Patraquim P and Alonso, C.R. (2017) Pervasive behavioural effects of microRNA regulation in Drosophila, Genetics 206(3):1535-1548 (published online 03 May 2017) [With "Issue highlight" comment in Genetics 206 (3)]

Vallejos Baier, R., Picao-Osorio, J. and Alonso, C.R. (2017) Molecular regulation of alternative polyadenylation (APA) within the Drosophila nervous system, Journal of Molecular Biology 429(21):3290-3300.

Warnefors, M., Hartmann, B., Thomsen, S. and Alonso, C.R. (2016) Combinatorial gene regulatory functions underlie ultraconserved elements (UCEs) in DrosophilaMolecular Biology and Evolution 33(9):2294-306. [doi: 10.1093/molbev/msw101].

Picao-Osorio, J, Johnston, J., Landgraf, M., Berni, J. and Alonso, C.R. (2015) microRNA encoded behavior in Drosophila, Science 350:815-20 (published online 22 October 2015) [DOI:10.1126/science.aad0217].

Casadio, A., Longman, D., Hug, N., Delavaine, L., Vallejos Baier, R., Alonso, C.R. and Cáceres, J.F. (2015) Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathways in nematodes, flies and mammals, EMBO Reports 16(1):71-8 [Dec 01, 2014 - Epub ahead of print]

Rogulja-Ortmann, A., Picao-Osorio, J., Villava, C., Patraquim, P., Lafuente, E., Aspden, J., Thomsen, S., Technau, G.M. and Alonso, C.R. (2014) The RNA binding protein ELAV/Hu regulates Hox RNA processing, expression and function within the Drosophila nervous system, Development
141:2046-56 [With "In this issue" highlight comment in Development 141 (10)]

Chipman, A.D., Ferrier, D.E.K., Brena, C., Qu, J., Hughes D.S.T., Schröder, R., Torres- Oliva, M., Znassi, N., Jiang, H., Almeida, F.C., Alonso, C.R., [...], Richards, S. (2014) The First Myriapod Genome Sequence Reveals Conservative Arthropod Gene Content and Genome Organisation in the Centipede Strigamia maritime, PLoS Biology 12(11):e1002005 [With "Synopsis" highlight comment in PLoS Biology issue Nov 25, 2014]

Costa, M., Calleja, M, Alonso, C.R.* and Simpson, P.* (2014) The bristle patterning genes hairy and extramachrochaetae regulate the development of structures required for flight in Diptera, Developmental Biology 388: 205-15 (*: corresponding authors). [Dec 30, 2013 - Epub ahead of print].

Mallo, M. and Alonso, C.R. (2013) The regulation of Hox gene expression during animal development, Development 140(19): 3951-63.

Alonso, C.R. (2013) Post-transcriptional gene regulation via RNA controlBrief. Funct. Genomics. 2013 Jan;12(1):1-2

Alonso, C.R. (2012) A complex 'mRNA degradation code' controls gene expression during animal development, Trends in Genetics 28(2):78-88

Patraquim, P., Warnefors, M. and Alonso, C.R. (2011) Evolution of Hox post-transcriptional regulation by alternative polyadenylation and microRNA modulation within twelve Drosophila genomes, Molecular Biology and Evolution 28(9):2453-2460 [Mar 24 - Epub ahead of print]

Avery, P., Vicente-Crespo, M., Francis, D., Nashchekina, O., Alonso, C.R. and Palacios, I.M. (2011) Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent manner, RNA 17(4):624-38 [Feb 11 - Epub ahead of print]

De Navas, L.F., Reed, H.C., Akam, M, Barrio, R., Alonso, C.R. and Sánchez-Herrero, E. (2011) Integration of RNA processing and expression level control modulates the functions of the Drosophila Hox gene Ultrabithorax during adult development, Development 138: 107-116.

Alonso, C.R. (2011) Gene Regulation in Eukaryotes, in Genetics: From Genes to Genomes, by Hartwell, Leland H. et al., Mc Graw Hill Press.

Thomsen, S., Anders, S., Janga, S.C., Huber, W. and Alonso, C.R. (2010) Genome-wide analysis of mRNA decay patterns during early Drosophila development Genome Biology 11 (9):R93 [21 September 2010] - [Selected for Genome BiologyEditors’ Picks”][Highly accessed article]

Thomsen, S., Azzam, G., Kaschula, R., Lucy S. Williams, and Alonso, C.R. (2010) Developmental RNA processing of 3'UTRs in Hox mRNAs as a context-dependent mechanism modulating visibility to microRNAs Development, 137 (17):2951-2960 [With "In this issue" highlight comment in Development 137 (17)] [***RECOMMENDED by the Faculty of 1000 Biology, see McDougall C, Degnan B: 2010.***]

Reed, H.C., Hoare, T., Thomsen, S, Weaver T.A., White, R.A.H., Akam, M. and Alonso, C.R. (2010) Alternative splicing modulates Ubx protein function in Drosophila melanogaster Genetics 184 (3): 745-758 [With "Highlights" comment in Genetics 184 (3)] / [2009 Dec 28, Epub ahead of print]

Alonso, C.R. (2008) The molecular biology underlying developmental evolution, in Evolving Pathways - Key Themes in Evolutionary Developmental Biology, Eds. Minelli, A. and Fusco, G., Cambridge University Press.

Alonso, C.R. (2007) Development, a genetic program in action, in Biology 7th, Eds. Curtis, H. et al., Panamerican Med. Press.

Alonso, C.R. and Wilkins A.S. (2005) The molecular elements that underlie developmental evolution, Nature Reviews Genetics, 6 (9): 709-715

Alonso, C.R. (2005) Nonsense-mediated RNA decay: a molecular system micromanaging individual gene activities and suppressing genomic noise, BioEssays, 27 (5):463-6

Chang, M.L., Chen, J.C., Alonso, C.R., Kornblihtt, A.R. and Bissell D.M. (2004) Regulation of fibronectin splicing in sinusoidal endothelial cells from normal or injured liver Proc. Natl. Acad. of Sciences USA, 101 (52): 18093-8

De la Mata, M., Alonso, C.R., Kadener, S., Fededa J.P., Blaustein M., Pelisch, F., Cramer, P., Bentley, D. and Kornblihtt, A.R. (2003) A slow RNA polymerase II affects alternative splicing in vivo, Molecular Cell, 12:525-532 - [With "News and Views" comment in Nature Struc. and Molec. Biol. (2003) 10:876-878] [***Evaluated as EXCEPTIONAL by the Faculty of 1000 Biology, see Bickmore W: 2003.***]

Alonso, C.R. and Akam, M. (2003) A Hox gene mutation that triggers Nonsense-mediated RNA decay and affects alternative splicing during Drosophila development, Nucleic Acids Res., 31 (14): 3873-80.

Roch, F., Alonso C.R. and Akam, M. (2003) Drosophila miniature and dusky encode ZP-proteins required for cytoskeletal reorganisation during wing morphogenesis, Journal of Cell Science, 116 (7): 1199-1207 - [With "In this issue" highlight comment in Journal of Cell Science, 116 (7)]

Alonso, C.R. (2002) Hox Proteins: Sculpting Body Parts by Activating Localised Cell Death, Current Biology, 12 (22): R776-R778.

Alonso, C.R., George,J., Pesce, C.G., Bissell D.M. & Kornblihtt, A.R. (2002) Fibronectin transcription in liver cells: promoter occupation and function in sinusoidal endothelial cells and hepatocytes, Biochem. Biophys. Res. Commun, 295 (5): 1077-84.

Alonso, C.R., Maxton-Kuechenmeister, J. and Akam, M.E. (2001) Evolution of Ftz protein function in insects, Current Biology, 11 (18): 1473-1478.

Rabinovich, G.A., Alonso, C.R., Sotomayor, C.E., Durand, S., Bocco, J.L. & Riera C.M. (2000) Molecular mechanisms implicated in galectin-1-induced apoptosis: activation of the AP-1 transcription factor and downregulation of Bcl-2 Cell Death and Differentiation, 7 (8): 747-753.

Pesce, C.G., Nogues, G., Alonso, C.R., Baralle F. & Kornblihtt, A.R. (1999) Interaction between the -170 CRE and the -150 CCAAT box is necessary for efficient activation of the fibronectin gene promoter by cAMP and ATF-2, FEBS Letters, 457: 445-451.

Alonso, C.R., Pesce, C.G. & Kornblihtt, A.R. (1996) The CCAAT-Binding Proteins CP1 and NF-I cooperate with ATF-2 in the transcription of the fibronectin gene,  J. Biol. Chem., 271:22271-279.

Kornblihtt, A.R., Pesce, C.G., Alonso, C.R., Cramer, P., Srebrow, A., Werbajh, S. and Muro, A.F. (1996) The fibronectin gene as a model for transcription and splicing studies, FASEB Journal, 10:248-257.



Mössinger, J and Alonso, C.R. (2004) Electronic evolution, Nature, 428 (6986):896.



NEW STUDY We are delighted to share the news that our latest study reporting a microRNA capable of controlling the emergence of embryonic movement in Drosophila has been published in eLife. Feel free to take a look: