School of Life Sciences

Paget Lab

We study the molecular biology of gene expression in bacteria with focus on the Actinobacteria. The large and ancient phylum Actinobacteria are Gram-postive bacteria with a high content of G+C in their DNA, and includes many bacteria of medical and industrial importance. For example, the Streptomyces genus are famous as the source of most clinically useful antibiotics, whereas the major human pathogen Mycobacterium tuberculosis kills more than 2 million people worldwide each year. Our primary model organism is the genetically and physiologically well-characterised Streptomyces coelicolor. We have recently widened our interests to include the control of fermentation in the bioethanol-producing thermophile Geobacillus thermoglucosidasius.

Current areas of interest include

  • Control of antibiotic production
  • RNA polymerase-binding factors
  • Redox sensing mechanisms
  • Control of gene expression in biofuel-producing microorganisms


Our work is currently funded by:

BBSRC logo

Paget Lab News

PhD studentship position available 2017

"Investigating RNA polymerase regulation in the antibiotic-producing Streptomyces bacteria"

For more information click here

New research reveals how the essential transcription factor RbpA works in Mycobacterium tuberculosis.

Hubin EA, Tabib-Salazar A, Humphrey LJ, Flack JE, Olinares PD, Darst SA, Campbell EA, Paget MS. (2015) Structural, functional, and genetic analyses of the actinobacterial transcription factor RbpA. Proc Natl Acad Sci U S A. 112:7171-6.

New review on sigma factors and their control available Open Access

Paget MS (2015) Bacterial Sigma Factors and Anti-Sigma Factors: Structure, Function and Distribution. Biomolecules 5, 1245-1265.


Dr Mark Paget

Reader in Molecular Genetics

University of Sussex
John Maynard Smith Building
Brighton, BN1 9QG


T +44 1273 877764

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