Murrell-Lagnado Lab



Srivats, S., Balasuriya, D., Pasche, M., Vistal, G., Edwardson, J. M., Taylor, C. W., and Murrell-Lagnado, R. D. (2016) Sigma1 receptors inhibit store-operated Ca2+ entry by attenuating coupling of STIM1 to Orai1. The Journal of Cell Biology 213, 65-79. DOI: 10.1083/jcb.201506022



Hardege, I., Xu, S., Gordon, R. D., Thompson, A. J., Figg, N., Stowasser, M., Murrell-Lagnado, R., and O'Shaughnessy, K. M. (2015) Novel Insertion Mutation in KCNJ5 Channel Produces Constitutive Aldosterone Release From H295R Cells. Molecular Endocrinology 29, 1522-1530. DOI: 10.1210/me.2015-1195

 Qi Cao, Xi Zoë Zhong, Yuanjie Zou, Ruth Murrell-Lagnado, Michael X. Zhu, and Xian-Ping Dong (2015)P2X4 functions as a lysosomal Ca2+ release channel involved in calmodulin-dependent lysosomal membrane fusion. The Journal of Cell Biology 209 No. 6 879–894. DOI: 10.1083/jcb.201409071.

Ruepp, M. D., Brozik, J. A., de Esch, I. J., Farndale, R. W., Murrell-Lagnado, R. D., and Thompson, A. J. (2015) A fluorescent approach for identifying P2X1 ligands. Neuropharmacology 98, 13-21 DOI: 10.1016/j.neuropharm.2015.05.016



Robinson, LE, Shridar, M, Smith, P, Murrell-Lagnado, RD (2014) Plasma membrane cholesterol as a regulator of human and rodent P2X7 receptor activation and sensitization. Journal of Biological Chemistry.  289, 31983-31994. DOI: 10.1074/jbc.M114.574699

Balasuriya D, Srivats S, Murrell-Lagnado, RD, Edwardson, JM  (2014) Atomic force microscopy (AFM) imaging suggests that stromal interaction molecule 1 (STIM1) binds to Orai1 with sixfold symmetry. FEBS Lett 588(17):2874-2880

Huang P, Zou Y, Zhong XZ, Cao Q, Zhao K, Zhu MX, Murrell-Lagnado, RD, Dong XP (2014) P2X4 Forms Functional ATP-activated Cation Channels on Lysosomal Membranes Regulated by Luminal pH. Journal of Biological Chemistry. 289 (25), 17658-17667



Robinson, LE, Murrell-Lagnado. RD (2013) The trafficking and targeting of P2X receptors. Frontiers in Cellular Neuroscience, 7, 233.



Xu XJ, Boumechache M, Robinson LE, Marschall V, Gorecki DC, Masin M, Murrell-Lagnado R.D. (2012) Splice-variants of the P2X7 receptor reveal differential agonist-dependence and functional coupling with pannexin-1. Journal of Cell Science. 125, 3776-89

Stewart AP, Gómez-Posada JC, McGeorge J, Rouhani MJ, Villarroel A, Murrell-Lagnado RD, Edwardson JM (2012) The Kv7.2/Kv7.3 heterotetramer assembles with a random subunit arrangement. Journal of Biological Chemistry 287(15):11870-11877

M. Masin, C. Young, K. Lim, S.J. Barnes, X.J. Xu, V. Marschall, W. Brutkowski , E.R. Mooney, D.C. Gorecki and R.D. Murrell-Lagnado (2012) Expression, assembly and function of novel C-terminal truncated variants of the mouse P2X7 receptor: Re-evaluation of P2X7 knockouts. British Journal of Pharmacology 165(4):978-993




L.S. Antonio, A.P. Stewart, X.J. Xu, W.A. Varanda, R.D. Murrell-Lagnado, J.M. Edwardson(2011) P2X4 receptors interact with both P2X2 and P2X7 receptors in the form of homotrimers. British Journal of Pharmacology 163, 1069-1077.

Gomez-Posada J.C, Etxeberria, A., Roura-Ferrer, M., Arerso, P., Masin, M., Murrell-Lagnado, R.D and Villarroel, A. (2010) A Pore Residue of the KCNQ3 Potassium M-Channel Subunit Controls Surface Expression. Journal of Neuroscience 30(27), 9316-23

Murrell-Lagnado RD. (2009) More cross talk between purinergic receptors. Journal of Physiology. 587, 2713-2714.

Nicke, A, Kuan Y-H, Masin, M., Bender, O., Rettinger, J., Marquez-Klaka, B., Górecki, D.C., Murrell-Lagnado, R.D., and Soto, F. (2009) A functional P2X7 splice variant with an alternative transmembrane domain I escapes gene inactivation in P2X7 KO mice. Journal of Biological Chemistry. 284, 25813-25822.

Boumechache, M, Masin, M, Edwardson, J.M, Gorecki, D.C. and Murrell-Lagnado, R.D. (2009) Analysis of assembly and trafficking of native P2X4 and P2X7 receptor complexes in rodent immune cells. Journal of Biological Chemistry. 284, 13446-13454.


Selected Publications pre-2009

Murrell-Lagnado R.D. and O. Qureshi. (2008) Assembly and trafficking of P2X purinergic receptors. Molecular Membrane Biology. 25(4) 321-331.

Qureshi, O.S, Paramasivam, A., Yu, J.C.H and Murrell-Lagnado R.D. (2007) Regulation of P2X4 receptors by lysosomal targeting, glycan protection and exocytosis Journal of Cell Science. 120, 3838-3849.

Guo, C., Masin, M., Qureshi, O.S. and Murrell-Lagnado R.D. (2007) Evidence for functional P2X4 / P2X7 heteromeric receptors. Molecular Pharmacology 72, 1447-1456.

Barrera, N.P., Henderson, R.M., Murrell-Lagnado, R.D. and Edwardson, J.M. (2007) The stoichiometry of P2X2/6 receptor heteromers depends on relative subunit expression levels. Biophysical Journal. 93, 505-512.

Ormond, S.G. Barrera, N.P. Qureshi, O.S. Henderson, R.M., Edwardson J.M. and Murrell-Lagnado R.D. (2006) An uncharged region within the N-terminus of the P2X6 receptor inhibits its assembly and exit from the endoplasmic reticulum Molecular Pharmacology. 69, 1692-1700.

Royle, S.J., Qureshi, O.S., Bobanovic, L.K., Evans, P.R., Owen D.J., and R. D. Murrell-Lagnado (2005) Non-canonical YXXGF endocytic motifs: recognition by AP2 and preferential utilization in P2X4 receptors. Journal of Cell Science.118:3073-80.

Barrera, N.P, Ormond, S.J., Henderson, R.M. Murrell-Lagnado, R.D. and Edwardson J.M. (2005) Atomic Force Microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize. Journal of Biological Chemistry. 18; 280(11): 10759-65

Royle S.J. and Murrell-Lagnado, R.D.  (2003) Constitutive cycling: a general mechanism to regulate cell surface proteins. BioEssays 25:39-46.

Bobanovic, L.K., Royle, S.J. and Murrell-Lagnado, R.D. (2002) P2X receptor trafficking in neurones in subunit specific. Journal of  Neuroscience. 22, 4814-4824.

Royle, S.J., Bobanovic, L.K. and Murrell-Lagnado, R.D. (2002) Identification of a non-canonical tyrosine based endocytic motif in an ionotropic receptor. Journal of Biological Chemistry. 277, 35378-35389.

Guo, Y, Waldron, G.J. and Murrell-Lagnado, R.D. (2002) A role for the middle C terminus of G-protein-activated inward rectifier potassium channels in regulating gating. Journal of Biological Chemistry. 277, 48289-48294.