Selected publications

E. Koya, S. Spijker, P. Voorn, E.D. Schimdt, R. Binnekade, A.N.M. Schoffelmeer, T.J. de Vries, A.B. Smit.  Enhanced cortical and accumbal reactivity associated with conditioned heroin, but not sucrose seeking. Journal of Neurochemistry. 2006 Aug;98(3):905-15.

L. Lu*, E. Koya*, H. Zhen, B.T. Hope, Y.Shaham.  Role of ERK in cocaine addiction.Trends in Neurosciences. 2006 Dec;29(12):695-703.

E. Koya, J.M. Bossert, J.L. Uejima, K. Wihbey, B.T. Hope, Y. Shaham.  Role of ventral medial prefrontal cortex in incubation of cocaine craving. Neuropharmacology. 2009;56 Suppl 1:177-85.

E. Koya, S.A. Golden, B.K. Harvey, D.H. Guez-Barber, A. Berkow, D.E. Simmons, J.M. Bossert, S.G. Nair, J.L. Uejima, M.T. Marin, T.B. Mitchell, D. Farquhar, S.C. Ghosh, B.J. Mattson, B.T. Hope.  *Targeted disruption of sparsely distributed cocaine-activated accumbens neurons prevents context-specific psychomotor sensitization. Nature Neuroscience. 2009 Aug;12(8):1069-73.

 *This article received a Faculty of 1000 Biology score of 14 after reviews from Drs. Marina Picciotto (Yale University, USA), Markus Heilig (National Institute on Alcohol Abuse and Alcoholism, USA) and Mark Mayford (The Scripps Research Institute, USA) and has been commented in Smith and Aston-Jones, Nature Neuroscience 12, 965-966, (2009) and Eisenstein, Nature Methods, 6, 630-631, (2009). The technique described in this article was used in Bossert et al., Nature Neuroscience 2011.

J.M. Bossert, A.L. Stern, F.R.M. Theberge, C. Cifani, E. Koya, B.T. Hope, Y. Shaham .  Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin seeking. Nature Neuroscience. 2011 Apr;14(4):420-2. (NIDA press release)

E. Koya, F.C. Cruz, R. Ator, S.A. Golden, A.F. Hoffman, C.R. Lupica, B.T. Hope.  *Synaptic remodeling in nucleus accumbens neurons recruited during cocaine sensitization. Nature Neuroscience. 2012 Nov;15(11):1556-62. doi: 10.1038/nn.3232. 

C.Cifani*, E. Koya*, B.M. Navarre, D.J. Calu, M. Baumann, N. Marchant, Q-R Liu, C. Lupica, Y. Shaham, B.T. Hope.  Stress-induced reinstatement of palatable food seeking is associated with unique physiological changes in medial prefrontal cortex activated neurons: a study with c-fos-GFP transgenic female rats. Journal of Neuroscience. 2012 Jun 20;32(25):8480-90. doi: 10.1523/JNEUROSCI.5895-11.2012.

F. Cruz, E. Koya, D.H. Guez-Barber, J.M. Bossert, C.R. Lupica, Y.Shaham, B.T. Hope. New technologies for examining neuronal ensembles in drug addiction and fear. Nature Reviews Neuroscience. 2013 Nov;14(11):743-54.

E.Koya, G. Margetts-Smith, and B.T. Hope, Daun02 inactivation of behaviorally-activated Fos-expressing neuronal ensembles. Curr. Protoc. Neurosci. 76:8.36.1-8.36.19.

N. Suto, A. Laque, G.L. De Ness, G. Wagner, D. Watry, T. Kerr, E. Koya, M. Mayford, B. Hope, F. Weiss. Distinct memory engrams in the infralimbic cortex of rats control opposing environmental actions on a learned behavior. eLife. 2016;10.7554/eLife.21920

J. Ziminski, S. Hessler, G. Margetts-Smith, M.C. Sieburg, H.S. Crombag, Koya, E. Changes in appetitive associative strength modulate nucleus accumbens, but not orbitofrontal cortex neuronal ensemble excitability. Journal of Neuroscience. 2017 Mar 22;37(12):3160-3170.

J.J. Ziminski, M.C. Sieburg, G. Margetts-Smith, H.S. Crombag, E. Koya. Regional Differences in Striatal Neuronal Ensemble Excitability Following Cocaine and Extinction Memory Retrieval in Fos-GFP Mice. Neuropsychopharmacology. 2018 Mar;43(4):718-727. doi: 10.1038/npp.2017.101. Epub 2017 May 25.

J.J. Ziminski, E. Koya. Reversing Cocaine-Induced Adaptations and Reducing Relapse: An Opportunity for Repurposing Riluzole. Neuropsychopharmacology. 2018 Jan 17. doi: 10.1038/npp.2017.300.

E. Koya, Y. Dong. Sound of silent synapses from the addicted hippocampus. Neuropsychopharmacology. 2018 Jul 20.

A. Laque, G. De Ness, G. E. Wagner, H. Nedelescu, A. Carroll, D. Watry, T. Kerr, E. Koya, B. T. Hope, F. Weiss, G. I. Elmer, N. Suto. Anti-relapse neurons in the infralimbic cortex of rats drive relapse-suppression by drug omission cues. Nature Communications. 2019 Sep 2;10(1):3934.

M.C. Sieburg, J.J. Ziminski, G. Margetts-Smith, H.M. Reeve, H.S. Crombag, E.Koya. Reward devaluation attenuates cue-evoked sucrose seeking and is associated with the elimination of excitability differences between ensemble and non-ensemble neurons in the nucleus accumbens. eNeuro. 2019 Dec 10;6(6).

*L.S. Brebner, *J.J. Ziminski, G. Margetts-Smith, M.C. Sieburg, H.M. Reeve, T. Nowotny, J. Hirrlinger, T.G. Heintz, L. Lagnado, S. Kato, K. Kobayashi, L.A. Ramsey, C.N. Hall, H.S. Crombag, E. Koya. The emergence of a stable neuronal ensemble from a wider pool of activated neurons in the dorsal medial prefrontal cortex during appetitive learning in mice. The Journal of Neuroscience. 2020 Jan 8;40(2):395-410.

*L.S. Brebner, *J.J. Ziminski, G. Margetts-Smith, M.C. Sieburg, T.G. Heintz, C.N. Hall, L. Lagnado, J. Hirrlinger,  H.S. Crombag, E. Koya. Extinction of cue-evoked food-seeking recruits a GABAergic interneuron ensemble in the dorsal medial prefrontal cortex of mice [published online ahead of print, 2020 Apr 20]. European Journal of Neuroscience. 2020;10.1111/ejn.14754.

G. Margetts-Smith, A.I. Macnaghten, L.S. Brebner, J.J. Ziminski, M.C. Sieburg, J.W. Grimm, H.S. Crombag, E. Koya. Acute, but not longer-term, exposure to environmental enrichment attenuates Pavlovian cue-evoked conditioned approach and Fos expression in the prefrontal cortex in mice. Eur J Neurosci. 2021 Feb 10. doi: 10.1111/ejn.15146. Epub ahead of print. 

A Laque, G.E. Wagner, A. Matzeu, G.L. De Ness, T.M. Kerr, A.M. Carroll, G. de Guglielmo, H. Nedelescu, M.W. Buczynski, A.M. Gregus, T.C. Jhou, E.P. Zorrilla, R. Martin-Fardon, E. Koya, R.C. Ritter, F. Weiss, N. Suto. Linking drug and food addiction via compulsive appetite. Br J Pharmacol. 2022 Jan 12. doi: 10.1111/bph.15797.

B.P.P. Lay, E. Koya, B.T. Hope, G.R. Esber & M.D. Iordanova. The recruitment of a neuronal ensemble in the CN during the first extinction episode has persistent effects on extinction expression. Biological Psychiatry. 2022, doi: https://doi.org/10.1016/j.biopsych.2022.07.021.