Research

 

My primary research interest is in the development and application of advanced microscopy techniques for the analysis of molecular movement and interaction in living tissues. 

I am collaborating with Dr Ian Roberts (BES) and the Cambridge Protein Trap Initiative in a screen of Drosophila lines with new fluorescent protein-protein fusions to identify and characterize proteins that change localization and mobility in response to signal transduction using Fluorescence Recovery After Photobleaching.  

Dr Julian Thorpe (Sussex Centre for Advanced Microscopy) and I are studying the regulation of Tau phosphorylation in Drosophila as a model for human neurodegenerative diseases.

I am collaborating with Prof Tony Carr (Genome Centre) and Dr Mark Osborne (Chemistry) to develop methods for analysis of protein interaction during DNA repair using Fluorescence Resonance Energy Transfer and Fluorescence Anisotropy. 

I am also working with members of the UoS Engineering and Design Department including Dr Philip Birch and Dr Rupert Young to develop new technology for faster more efficient measurement of Fluorescence Lifetime and Anisotropy.