Oliver Lab



Day, MatthewRappas, MathieuPtasinska, KatieBoos, DominikOliver, Antony W and Pearl, Laurence H (2018) BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands.eLife, 7 (e39979). pp. 1-18. ISSN 2050-084X

Robinson, Sophie RViegas, Sandra CMatos, Rute GDomingues, SusanaBedir, MarisaStewart, Helen J SChevassut, TimothyOliver, Antony WArraiano, Cecilia M and Newbury, Sarah F (2018) DIS3 isoforms vary in their endoribonuclease activity and are differentially expressed within haematological cancers. Biochemical Journal, 475 (12). pp. 2091-2105. ISSN 0264-6021

Mok, Myth TZhou, JingyingTang, WenshuZeng, XuezhenOliver, Antony WWard, Simon E and Cheng, Alfred S L(2018) CCRK is a novel signalling hub exploitable in cancer immunotherapy. Pharmacology and Therapeutics. ISSN 0163-7258

Alt, AaronDang, Hung QWells, Owen SPolo, Luis MSmith, Matt AMcGregor, Grant AWelte, ThomasLehmann, Alan RPearl, Laurence HMurray, Johanne M and Oliver, Antony W (2017) Specialized interfaces of Smc5/6 control hinge stability and DNA association. Nature Communications, 8. p. 14011. ISSN 2041-1723

Ocasio, Cory ARajasekaran, Mohan BWalker, SarahLe Grand, DarrenSpencer, JohnPearl, Frances M GWard, Simon ESavic, VeliborPearl, Laurence HHochegger, Helfrid and Oliver, Antony W (2016) A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct.Oncotarget, 7 (44). 71182 -71197. ISSN 1949-2553

Grundy, Gabrielle JPolo, Luis MZeng, ZhihongRulten, StuartHoch, NicolasPathompong, PaomephanXu, YingqiSweet, Steve MThorne, Alan WOliver, Antony WMatthews, Steve JPearl, Laurence H and Caldecott, Keith W (2016)PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2). Nature Communications, 7 (12404). ISSN 2041-1723

van der Crabben, Saskia NHennus, Marije PMcGregor, GrantRitter, Deborah INagamani, Sandesh C SWells, Owen SHarakalova, MagdalenaChinn, Ivan KAlt, AaronVondrova, LucieHochstenbach, Ronvan Montfrans, Joris MTerheggen-Lagro, Suzanne Wvan Lieshout, Stefvan Roosmalen, Markus JRenkens, IvoDuran, KarenNijman, Isaac JKloosterman, Wigard PHennekam, EricOrange, Jordan Svan Hasselt, Peter MWheeler, David APalecek, Jan JLehmann, Alan ROliver, Antony WPearl, Laurence HPlon, Sharon EMurray, Johanne M and van Haaften, Gijs(2016) Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease. Journal of Clinical Investigation, 126 (8). pp. 2881-2892. ISSN 0021-9738

Hornyak, PeterAskwith, TrevorWalker, SarahKomulainen, EmiliaParadowski, MichaelPennicott, Lewis EBartlett, Edward JBrissett, Nigel CRaoof, AliWatson, MandyJordan, Allan MOgilvie, Donald JWard, Simon EAtack, John RPearl, Laurence HCaldecott, Keith W and Oliver, Antony W (2016) Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochemical Journal, 473 (13). pp. 1869-1879. ISSN 0264-6021

Grundy, Gabrielle JRulten, Stuart LArribas-Bosacoma, RaquelDavidson, KathrynKozik, ZuzannaOliver, Antony WPearl, Laurence H and Caldecott, Keith W (2016) The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins. Nature Communications, 7. a11242. ISSN 2041-1723

McKinnon, PeterByrd, Philip JStewart, Grant. SSmith, AnnaEaton, CharlotteTaylor, Alexander JGuy, ChloeEringyte, IevaFooks, PeggyLast, James IHorsley, RobertOliver, Antony WJanic, DraganaDokmanovic, LidijaStankovic, Tatjana and Taylor, A Malcolm R (2016) A hypomorphic PALB2 allele gives rise to an unusual form of FA-N associated with lymphoid tumour development. PLoS Genetics, 12 (3). e1005945. ISSN 1553-7404

Zabrady, KaterinaAdamus, MarekVondrova, LucieLiao, ChunyanSkoupilova, HanaNovakova, MarketaJurcisinova, LenkaAlt, AaronOliver, Antony WLehmann, Alan R and Palecek, Jan J (2016) Chromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA. Nucleic Acids Research, 44 (3). pp. 1064-1079. ISSN 1362-4962

Donato, Nataliya DiRump, AndreasMirzaa, Ghayda MAlcantara, DianaOliver, AntonySchrock, EvelinDobyns, William B and O'Driscoll, Mark (2015) Identification and characterisation of a novel constitutional PIK3CA mutation in a child lacking the typical segmental overgrowth of "PIK3CA-Related Overgrowth Spectrum" (PROS). Human Mutation, 37 (3). pp. 242-245. ISSN 1059-7794

Baldock, Robert ADay, MatthewWilkinson, Oliver JCloney, RossJeggo, Penelope AOliver, Antony WWatts, Felicity Z and Pearl, Laurence H (2015) ATM localization and heterochromatin repair depend on Direct Interaction of the 53BP1-BRCT2 domain with γH2AX. Cell Reports, 13 (10). pp. 2081-2089. ISSN 2211-1247

Robinson, Sophie ROliver, Antony WChevassut, Timothy J and Newbury, Sarah F (2015) The 3' to 5' exoribonuclease DIS3: from structure and mechanisms to biological functions and role in human disease. Biomolecules, 5 (3). pp. 1515-1539. ISSN 2218-273X

Breslin, ClaireHornyak, PeterRidley, AndrewRulten, Stuart LHanzlikova, HanaOliver, Antony W and Caldecott, Keith W (2015) The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function.Nucleic Acids Research, 43 (14). pp. 6934-6944. ISSN 0305-1048

Wardlaw, Christopher PCarr, Antony M and Oliver, Antony W (2014) TopBP1: A BRCT-scaffold protein functioning in multiple cellular pathways. DNA Repair, 22. pp. 165-174. ISSN 1568-7864

Walker, SarahMeisenberg, CorneliaBibby, Rachel AAskwith, TrevorWilliams, GarethRininsland, Frauke HPearl, Laurence HOliver, Antony WEl-Khamisy, SherifWard, Simon and Atack, John R (2014) Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.Analytical Biochemistry, 454. pp. 17-22. ISSN 0003-2697

Hegarat, NadiaVesely, ClareOcasio, TonyPeter, NishaOliver, Antony and Hochegger, Helfrid (2014) PP2A/B55 and Fcp1 regulate Greatwall and Ensa Dephosphorylation during mitotic exit. PLOS Genetics, 10 (1). ISSN 1553-7390

Fontebasso, YEtheridge, T JOliver, A WMurray, J M and Carr, A M (2013) The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast. DNA Repair, 12 (12). pp. 1011-1023. ISSN 15687864

Chambers, Anna LPearl, Laurence HOliver, Antony W and Downs, Jessica A (2013) The BAH domain of Rsc2 is a histone H3 binding domain. Nucleic Acids Research, 41 (19). pp. 9168-9182. ISSN 0305-1048

Silva-Santisteban, M CrisWestwood, Isaac MBoxall, KathyBrown, NathanPeacock, SamMcAndrew, CraigBarrie, ElaineRichards, MeirionMirza, AminOliver, Antony WBurke, RosemaryHoelder, SwenJones, KeithAherne, G WynneBlagg, JulianCollins, IanGarrett, Michelle D and van Montfort, Rob L M (2013) Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2. PLoS ONE, 8 (6). e65689. ISSN 1932-6203

Grundy, Gabrielle LRulten, Stuart LZeng, ZhihongArribas-Bosacoma, RaquelIles, NatashaManley, KatieOliver, Antony and Caldecott, Keith W (2013) APLF promotes the assembly and activity of non-homologous end joining protein complexes. The EMBO journal, 32 (1). pp. 112-125. ISSN 1460-2075

Qu, MengRappas, MathieuWardlaw, Christopher PGarcia, ValerieRen, Jing-YiDay, MatthewCarr, Antony MOliver, AntonyDu, Li-Lin and Pearl, Laurence (2013) Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4TopBP1. Molecular Cell, 51 (6). pp. 723-736. ISSN 1097-2765

Brownlee, Peter MChambers, Anna LOliver, Antony W and Downs, Jessica A (2012) Cancer and the bromodomains of BAF180. Biochemical Society Transactions, 40 (2). pp. 364-369. ISSN 0300-5127

Ali, Ammar A ETiminszky, GyulaArribas-Bosacoma, RaquelKozlowski, MarekHassa, Paul OHassler, MarkusLadurner, Andreas GPearl, Laurence H and Oliver, Antony W (2012) The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks. Nature Structural & Molecular Biology, 9 (7). pp. 685-692. ISSN 1545-9985

Garces, FernandoPearl, Laurence H and Oliver, Antony W (2011) The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase. Molecular Cell, 44 (3). 385 - 396. ISSN 1097-2765

Boos, DominikSanchez-Pulido, LuisRappas, MathieuPearl, Laurence HOliver, Antony WPonting, Chris P and Diffley, John F X (2011) Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans. Current Biology, 21 (13). pp. 1152-1157. ISSN 0960-9822

Caldwell, John JWelsh, Emma JMatjissen, CornelisAnderson, Victoria EAntoni, LaurentBoxall, KathyUrban, FrederiqueHayes, AngelaRaynaud, Florence IRigoreau, Laurent J MRaynham, TonyAherne, G WynnePearl, Laurence HOliver, Antony WGarrett, Michelle D and Collins, Ian (2011) Structure-Based Design of Potent and Selective 2-(Quinazolin-2-yl)phenol Inhibitors of Checkpoint Kinase 2. Journal of Medicinal Chemistry, 54 (2). pp. 580-590. ISSN 0022-2623

Anderson, Victoria EWalton, Michael IEve, Paul DBoxall, Katherine JAntoni, LaurentCaldwell, John JAherne, WynnePearl, Laurence HOliver, Antony WCollins, Ian and Garrett, Michelle D (2011) CCT241533 Is a Potent and Selective Inhibitor of CHK2 that Potentiates the Cytotoxicity of PARP Inhibitors. Cancer Research, 71 (2). pp. 463-472. ISSN 0008-5472

Rappas, MathieuOliver, Antony W and Pearl, Laurence H (2011) Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1. Nucleic Acids Research, 39 (1). pp. 313-324. ISSN 0305-1048

Woodbine, LisaGrigoriadoub, SofiaGoodarzi, Aaron ARiballo, EnriquetaTape, ChristopherOliver, Antony Wvan Zelm, Menno CBuckland, Matthew SDavies, E GrahamPearl, Laurence H and Jeggo, Penny A (2010) An Artemis polymorphic variant reduces Artemis activity and confers cellular radiosensitivity. DNA Repair, 9 (9). pp. 1003-1010. ISSN 1568-7864

Hilton, StephenNaud, SebastienCaldwell, John JBoxall, KathyBurns, SamanthaAnderson, Victoria EAntoni, LaurentAllen, Charlotte EPearl, Laurence HOliver, Antony WAherne, G WynneGarrett, Michelle D and Collins, Ian(2010) Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2. Bioorganic & Medicinal Chemistry, 18 (2). pp. 707-718. ISSN 0968-0896

Oliver, Antony WSwift, SallyLord, Christopher JAshworth, Alan and Pearl, Laurence H (2009) Structural basis for recruitment of BRCA2 by PALB2. EMBO Reports, 10 (9). pp. 990-996. ISSN 1469-221X

Ali, Ammar A. E.Jukes, Rachel M.Pearl, Laurence H. and Oliver, Antony W. (2009) Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK. Nucleic Acids Research, 37 (5). pp. 1701-1712. ISSN 0305-1048

Pike, Ashley C WRellos, PeterNiesen, Frank HTurnbull, AndrewOliver, Antony WParker, Sirlester ATurk, Benjamin EPearl, Laurence H and Knapp, Stefan (2008) Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. EMBO Journal, 27 (4). pp. 704-714. ISSN 0261-4189

Oliver, Antony WKnapp, Stefan and Pearl, Laurence H (2007) Activation segment exchange: a common mechanism of kinase autophosphorylation? Trends in Biochemical Science, 32 (8). pp. 351-356.

Dore, A SKilkenny, M LJones, S AOliver, A WRoe, S MBell, S D and Pearl, L H (2006) Structure of an archaeal PCNA1-PCNA2-FEN1 complex: elucidating PCNA subunit and client enzyme specificity. Nucleic Acids Research, 34 (16). pp. 4515-4526.

Oliver, Antony WPaul, AngelaBoxall, Katherine JBarrie, S ElaineAherne, G WynneGarrett, Michelle DMittnacht, Sibylle and Pearl, Laurence H (2006) Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange. EMBO Journal, 25 (13). pp. 3179-3190. ISSN 0261-4189

Oliver, Antony WJones, Sarah ARoe, Stephen MarkMatthews, SteveGoodwin, Graham H and Pearl, Laurence H(2005) Crystal structure of the proximal BAH domain of the polybromo protein. Biochemical Journal, 389 (3). pp. 657-664. ISSN 0264-6021

Oliver, A WAmé, J CRoe, S MGood, Vde Murcia, G and Pearl, L H (2004) Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2. Nucleic Acids Research, 32 (2). pp. 456-464. ISSN 0305-1048

Oliver, Antony WBogdarina, IrinaSchroeder, EwaldTaylor, Ian A and Kneale, G Geoff (2000) Preferential binding of fd gene 5 protein to tetraplex nucleic acid structures. Journal of Molecular Biology, 301 (3). pp. 575-584.

Oliver, Antony W and Kneale, G Geoff (1999) Structural characterization of DNA and RNA sequences recognized by the gene 5 protein of bacteriophage fd. Biochemical Journal, 339 (3). pp. 525-531.

Oliver, Antony W and Kneale, G Geoff (1997) Preferential binding of the fd gene 5 protein to a structured form of the single-stranded DNA sequence d(GT5G4CT4C). Biochemical Society Transactions, 25 (4). S643.

Book Section

Oliver, AntonyCarpenter, ML and Kneale, GG (2001) Analysis of DNA-protein interactions by intrinsic fluorescence. In: Methods in Molecular Biology. Unset, pp. 491-502.

Carpenter, M LOliver, A W and Kneale, G G (2001) Circular dichroism for the analysis of protein-DNA interactions. In: Methods in Molecular Biology. Unset, pp. 503-510.


Cancer Research Technology Ltd; Collins, Ian; Caldwell, John J; Oliver, Antony W; Raynham, Tony M; Welsh, Emma J; Matijssen, Cornelius A J (2008) Therapeutic oxy-phenyl-aryl compounds and their use. PCT/GB2008/003586.

Publications with Abstracts and Links

Link to PubMed