Eyre-Walker Lab


Professor Adam Eyre-Walker

A full list of publications with PDFs can be found here


Soni, Vivak, Vos, Michiel and Eyre-Walker, Adam (2022) A new test suggests hundreds of amino acid polymorphisms in humans are subject to balancing selection. PLoS Biology, 20 (6). e3001645 1-27. ISSN 1544-9173

Dazeniere, Julie, Bousios, Alexandros and Eyre-Walker, Adam (2022) Patterns of selection in the evolution of a transposable element. G3 (Bethesda, Md.), 12. jkac056 1-10. ISSN 2160-1836

Soni, Vivak, Moutinho, Ana Filipa and Eyre-Walker, Adam (2022) Changing population size in McDonald-Kreitman style analyses: artifactual correlations and adaptive evolution between humans and chimpanzees. Genome biology and evolution, 14 (2). pp. 1-11. ISSN 1759-6653

Soni, Vivak and Eyre-Walker, Adam (2022) Factors that affect the rates of adaptive and nonadaptive evolution at the gene level in humans and chimpanzees. Genome biology and evolution, 14 (2). pp. 1-13. ISSN 1759-6653

Castellano, David, Eyre-Walker, Adam and Munch, Kasper (2019) Impact of mutation rate and selection at linked sites on DNA variation across the genomes of humans and other homininae. Genome Biology and Evolution. ISSN 1759-6653

Gibson, Beth and Eyre-Walker, Adam (2019) Investigating evolutionary rate variation in bacteria. Journal of Molecular Evolution. ISSN 0022-2844

Vigué, Lucile and Eyre-Walker, Adam (2019) The comparative population genetics of Neisseria meningitidis and Neisseria gonorrhoeae. PeerJ, 7. e7216 1-20. ISSN 2167-8359

Bergman, Juraj, Eyre-Walker, Adam and Unset (2019) Does adaptive protein evolution proceed by large or small steps at the amino acid level? Molecular Biology and Evolution, 36 (5). pp. 990-998. ISSN 0737-4038

Castellano, David, James, Jennifer and Eyre-Walker, Adam (2018) Nearly neutral evolution across the Drosophila melanogaster genome. Molecular Biology and Evolution, 35 (11). pp. 2685-2694. ISSN 0737-4038

Gibson, Beth, Wilson, Daniel J, Feil, Edward and Eyre-Walker, Adam (2018) The distribution of bacterial doubling times in the wild. Proceedings of the Royal Society B: Biological Sciences, 285 (1880). 20180789 1-9. ISSN 0962-8452

Vos, Michiel and Eyre-Walker, Adam (2017) Are pangenomes adaptive or not? Nature Microbiology, 2 (12). p. 1576. ISSN 2058-5276

Blanc-Mathieu, Romain, Krasovec, Marc, Hebrard, Maxime, Yau, Sheree, Desgranges, Elodie, Martin, Joel, Schackwitz, Wendy, Kuo, Alan, Salin, Gerald, Donnadieu, Cecile, Desdevises, Yves, Sanchez-Ferandin, Sophie, Moreau, Hervé, Rivals, Eric, Grigoriev, Igor V, Grimsley, Nigel, Eyre-Walker, Adam and Piganeau, Gwenael (2017) Population genomics of picophytoplankton unveils novel chromosome hypervariability. Science Advances, 3 (7). e1700239. ISSN 2375-2548

Krasovec, Marc, Eyre-Walker, Adam, Sanchez-Ferandin, Sophie and Piganeau, Gwenael (2017) Spontaneous mutation rate in the smallest photosynthetic eukaryotes. Molecular Biology and Evolution, 34 (7). pp. 1770-1779. ISSN 0737-4038

Eyre-Walker, Adam (2017) Mitochondrial replacement therapy: are mito-nuclear interactions likely to be a problem? Genetics, 205 (4). pp. 1365-1372. ISSN 0016-6731

James, J, Castellano, D and Eyre-Walker, A (2016) DNA sequence diversity and the efficiency of natural selection in animal mitochondrial DNA. Heredity, 2017 (118). pp. 88-95. ISSN 0018-067X

Smith, Thomas C A, Carr, Antony M and Eyre-Walker, Adam C (2016) Are sites with multiple single nucleotide variants in cancer genomes a consequence of drivers, hypermutable sites or sequencing errors? PeerJ, 4. e2391 1-15. ISSN 2167-8359

James, Jennifer E, Lanfear, Robert and Eyre-Walker, Adam (2016) Molecular evolutionary consequences of island colonization. Genome Biology and Evolution, 8 (6). pp. 1876-1888. ISSN 1759-6653

Krasovec, Marc, Eyre-Walker, Adam, Grimsley, Nigel, Salmeron, Christophe, Pecqueur, David, Piganeau, Gwenael and Sanchez-Ferandin, Sophie (2016) Fitness effects of spontaneous mutations in picoeukaryotic marine green algae. G3, 6 (7). pp. 2063-2071. ISSN 2160-1836

Smith, Thomas, Ho, Gladys, Christodoulou, John, Price, Elizabeth Ann, Onadim, Zerrin, Gauthier-Villars, Marion, Dehainault, Catherine, Houdayer, Claude, Parfait, Beatrice, van Minkelen, Rick, Lohman, Dietmar and Eyre-Walker, Adam (2016) Extensive variation in the mutation rate between and within human genes associated with Mendelian disease. Human Mutation, 37 (5). pp. 488-494. ISSN 1059-7794

Castellano, David, Coronado-Zamora, Marta, Campos, Jose L, Barbadilla, Antonio and Eyre-Walker, Adam (2016) Adaptive evolution is substantially impeded by Hill–Robertson interference in Drosophila. Molecular Biology and Evolution, 33 (2). pp. 442-455. ISSN 0737-4038

James, Jennifer E, Piganeau, Gwenael and Eyre-Walker, Adam (2016) The rate of adaptive evolution in animal mitochondria. Molecular Ecology, 25 (1). pp. 67-78. ISSN 0962-1083

Vos, Michiel, Hesselman, Matthijn C, te Beek, Tim A, van Passel, Mark W J and Eyre-Walker, Adam (2015) Rates of lateral gene transfer in prokaryotes: high but why? Trends in Microbiology, 23 (10). pp. 598-605. ISSN 0966-842X

Cook, Isabelle, Grange, Sam and Eyre-Walker, Adam (2015) Research groups: How big should they be? PeerJ, 3. e989. ISSN 2167-8359

Eyre-Walker, Adam and Eyre-Walker, Ying Chen (2014) How much of the variation in the mutation rate along the human genome can be explained? G3, 4 (9). pp. 1667-1670. ISSN 2160-1836

Chen Eyre-Walker, Ying and Eyre-Walker, Adam (2014) The role of mutation rate variation and genetic diversity in the architecture of human disease. PLoS ONE, 9. e90166. ISSN 1932-6203

Gossmann, Toni I, Waxman, David and Eyre-Walker, Adam (2014) Fluctuating selection models and Mcdonald-Kreitman type analyses. PLoS ONE, 9 (1). e84540. ISSN 1932-6203

Lanfear, Robert, Kokko, Hanna and Eyre-Walker, Adam (2014) Population size and the rate of evolution. Trends in Ecology and Evolution, 29 (1). pp. 33-41. ISSN 0169-5347

Eyre-Walker, Adam and Stoletzki, Nina (2013) The assessment of science: the relative merits of post- publication review, the impact factor, and the number of citations. PLoS Biology, 11 (10). e1001675. ISSN 1544-9173

Blanc-Mathieu, Romain, Sanchez-Ferandin, Sophie, Eyre-Walker, Adam and Piganeau, Gwenael (2013) Organellar inheritance in the green lineage: insights from Ostreococcus tauri. Genome Biology and Evolution, 5 (8). pp. 1503-1511. ISSN 1759-6653

Lesecque, Yann, Keightley, Peter D and Eyre-Walker, Adam (2012) A resolution of the mutation load paradox in humans. Genetics, 112. p. 140343. ISSN 1943-2631

Warnefors, Maria and Eyre-Walker, Adam (2012) A selection index for gene expression evolution and its application to the divergence between humans and chimpanzees. PLoS ONE, 7 (4). e34935. ISSN 1932-6203

Gossmann, Toni I, Keightley, Peter D and Eyre-Walker, Adam (2012) The effect of variation in the effective population size on the rate of adaptive molecular evolution in eukaryotes. Genome Biology and Evolution, 4 (5). pp. 658-667. ISSN 1759-6653

Keightley, Peter D and Eyre-Walker, Adam (2012) Estimating the rate of adaptive molecular evolution when the evolutionary divergence between species is small. Journal of Molecular Evolution, 74 (1-2). pp. 61-68. ISSN 1432-1432

Ladoukakis, Emmanuel, Pereira, Vini, Magny, Emile G, Eyre-Walker, Adam and Couso, Juan Pablo (2011) Hundreds of putatively functional small open reading frames in Drosophila. Genome Biology, 12 (11). R118. ISSN 1465-6914

Awadalla, Philip, Gauthier, Julie, Myers, Rachel A, Casals, Ferran, Hamdan, Fadi F, Griffing, Alexander R, Côté, Mélanie, Henrion, Edouard, Spiegelman, Dan, Tarabeux, Julien, Piton, Amélie, Yang, Yan, Boyko, Adam, Bustamante, Carlos, Xiong, Lan, Rapoport, Judith L, Addington, Anjené M, DeLisi, J Lynn E, Krebs, Marie-Odile, Joober, Ridha, Millet, Bruno, Fombonne, Éric, Mottron, Laurent, Zilversmit, Martine, Keebler, Jon, Daoud, Hussein, Marineau, Claude, Roy-Gagnon, Marie-Hélène, Dubé, Marie-Pierre, Eyre-Walker, Adam, Drapeau, Pierre, Stone, Eric A, Lafrenière, Ronald G and Rouleau, Guy A (2010) Direct Measure of the De Novo Mutation Rate in Autism and Schizophrenia Cohorts. American Journal of Human Genetics, 87 (3). pp. 316-324. ISSN 0002-9297

Eyre-Walker, Adam (2010) Evolution in health and medicine Sackler colloquium: Genetic architecture of a complex trait and its implications for fitness and genome-wide association studies. Proceedings of the National Academy of Sciences of the United States of America, 107 (S1). pp. 1752-1756. ISSN 1091-6490

Eyre-Walker, Adam, Woolfit, Megan and Phelps, Ted (2006) The distribution of fitness effects of new deleterious amino acid mutations in humans. Genetics, 173 (2). pp. 891-900. ISSN 0016-6731