Doherty Group

Selected Publications: 2002-Present

Article

Li, Arthur W H, Zabrady, Katerina, Bainbridge, Lewis J, Zabrady, Matej, Naseem-Khan, Sehr, Berger, Madison B, Kolesar, Peter, Cisneros, G Andrés and Doherty, Aidan J (2022) Molecular basis for the initiation of DNA primer synthesis. Nature. ISSN 0028-0836

Bailey, Laura J, Teague, Rebecca, Kolesar, Peter, Bainbridge, Lewis J, Lindsay, Howard D and Doherty, Aidan J (2021) PLK1 regulates the PrimPol damage tolerance pathway during the cell cycle. Science Advances, 7 (49). pp. 1-15. ISSN 2375-2548

Zabrady, Katerina, Zabrady, Matej, Kolesar, Peter, Li, Arthur W H and Doherty, Aidan J (2021) CRISPR-Associated Primase-Polymerases are implicated in prokaryotic CRISPR-Cas adaptation. Nature Communications, 12 (1). a3690 1-18. ISSN 2041-1723

Bainbridge, Lewis J, Teague, Rebecca and Doherty, Aidan J (2021) Repriming DNA synthesis: an intrinsic restart pathway that maintains efficient genome replication. Nucleic Acids Research, 49 (9). pp. 4831-4847. ISSN 0305-1048

Piberger, Ann Liza, Bowry, Akhil, Kelly, Richard D W, Walker, Alexandra K, González-Acosta, Daniel, Bailey, Laura J, Doherty, Aidan J, Méndez, Juan, Morris, Joanna R, Bryant, Helen E and Petermann, Eva (2020) PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts. Nature Communications, 11 (1). a5863 1-14. ISSN 2041-1723

Brissett, Nigel C, Zabrady, Katerina, Płociński, Przemysław, Bianchi, Julie, Korycka-Machała, Małgorzata, Brzostek, Anna, Dziadek, Jarosław and Doherty, Aidan J (2020) Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C. Nature Communications, 11. a4196. ISSN 2041-1723

Butler, Thomas J, Estep, Katrina N, Sommers, Joshua A, Maul, Robert W, Moore, Ann Zenobia, Bandinelli, Stefania, Cucca, Francesco, Tuke, Marcus A, Wood, Andrew R, Bharti, Sanjay Kumar, Bogenhagen, Daniel F, Yakubovskaya, Elena, Garcia-Diaz, Miguel, Guilliam, Thomas A, Byrd, Alicia K, Raney, Kevin D, Doherty, Aidan J, Ferrucci, Luigi, Schlessinger, David, Ding, Jun and Brosh, Jr, Robert M (2020) Mitochondrial genetic variation is enriched in G-quadruplex regions that stall DNA synthesis in vitro. Human Molecular Genetics, 29 (8). pp. 1292-1309. ISSN 0964-6906

Bailey, Laura J, Bianchi, Julie and Doherty, Aidan J (2019) PrimPol is required for the maintenance of efficient nuclear and mitochondrial DNA replication in human cells. Nucleic Acids Research, 47 (8). pp. 4026-4038. ISSN 0305-1048

Šviković, Sasa, Crisp, Alastair, Tan-Wong, Sue Mei, Guilliam, Thomas A, Doherty, Aidan J, Proudfoot, Nicholas, Guilbaud, Guillaume and Sale, Julian (2018) R-loop formation during S phase is restricted by PrimPol-mediated repriming. The EMBO Journal, 38 (3). e99793 1-19. ISSN 0261-4189

Maina, Mahmoud B, Bailey, Laura J, Doherty, Aidan J and Serpell, Louise C (2018) The involvement of Aβ42 and tau in nucleolar and protein synthesis machinery dysfunction. Frontiers in Cellular Neuroscience, 12 (220). pp. 1-13. ISSN 1662-5102

Maina, Mahmoud B, Bailey, Laura J, Wagih, Sherin, Biasetti, Luca, Pollack, Saskia J, Quinn, James P, Thorpe, Julian R, Doherty, Aidan J and Serpell, Louise C (2018) The involvement of tau in nucleolar transcription and the stress response. Acta Neuropathologica Communications, 6 (70). pp. 1-13. ISSN 2051-5960

Silva, Joana, Aivio, Suvi, Knobel, Philip A, Bailey, Laura, Casali, Andreu, Vinaixa, Maria, Garcia-Cao, Isabel, Coyaud, Étienne, Jourdain, Alexis A, Perez-Ferreros, Pablo, Rojas, Ana M, Antolin-Fontes, Albert, Samino-Gené, Sara, Raught, Brian, González-Reyes, Acaimo, Ribas de Pouplana, Lluis, Doherty, Aidan J, Yanes, Oscar and Stracker, Travis H (2018) EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation. Nature Cell Biology, 20. pp. 162-174. ISSN 1465-7392

Plocinski, Przemyslaw, Brissett, Nigel C, Bianchi, Julie, Brzostek, Anna, Korycka-Machała, Małgorzata, Dziembowski, Andrzej, Dziadek, Jaroslaw and Doherty, Aidan J (2017) DNA Ligase C and Prim-PolC participate in base excision repair in mycobacteria. Nature Communications, 8 (1). a1251 1-12. ISSN 2041-1723

Guilliam, Thomas A, Brissett, Nigel C, Ehlinger, Aaron, Keen, Benjamin A, Kolesar, Peter, Taylor, Elaine, Bailey, Laura J, Lindsay, Howard, Chazin, Walter J and Doherty, Aidan J (2017) Molecular basis for PrimPol recruitment to replication forks by RPA. Nature Communications, 8. a15222. ISSN 2041-1723

Bailey, Laura and Doherty, Aidan (2017) Mitochondrial DNA replication: a PrimPol perspective. Biochemical Society Transactions, 45 (2). pp. 513-529. ISSN 0300-5127

Castañeda-García, A, Prieto, A I, Rodríguez-Beltrán, J, Alonso, N, Cantillon, D, Costas, C, Pérez-Lago, L, Zegeye, E D, Herranz, M, Plociński, P, Tonjum, T, García de Viedma, D, Paget, M, Waddell, S J, Rojas, A M, Doherty, A J and Blázquez, J (2017) A non-canonical mismatch repair pathway in prokaryotes. Nature Communications, 8. a14246. ISSN 2041-1723

Guilliam, Thomas A and Doherty, Aidan J (2017) Current and emerging assays for studying the primer synthesis activities of DNA primases. Methods Enzymol, 591. pp. 327-353. ISSN 0076-6879

Guilliam, Thomas A and Doherty, Aidan J (2017) Primpol—prime time to reprime. Genes, 8 (1). a20 1-25. ISSN 2073-4425

Kobayashi, Kaori, Guilliam, Thomas A, Tsuda, Masataka, Yamamoto, Junpei, Bailey, Laura J, Iwai, Shigenori, Takeada, Shunichi, Doherty, Aidan J and Hirota, Kouji (2016) Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain terminating nucleosides. Cell Cycle, 15 (15). pp. 1997-2008. ISSN 1538-4101

Guilliam, Thomas A, Bailey, Laura J, Brissett, Nigel C and Doherty, Aidan J (2016) PolDIP2 interacts with human PrimPol and enhances its DNA polymerase activities. Nucleic Acids Research, 44 (7). pp. 3317-3329. ISSN 0305-1048

Bartlett, Edward J, Brissett, Nigel C, Plocinski, Przemyslaw, Carlberg, Tom and Doherty, Aidan J (2016) Molecular basis for DNA strand displacement by NHEJ repair polymerases. Nucleic Acids Research, 44 (5). pp. 2173-2186. ISSN 0305-1048

Schiavone, Davide, Jozwiakowski, Stanislaw K, Romanello, Marina, Guilbaud, Guillaume, Guilliam, Thomas A, Bailey, Laura J, Sale, Julian E and Doherty, Aidan J (2016) PrimPol is required for replicative tolerance of G quadruplexes in vertebrate cells. Molecular Cell, 61 (1). pp. 161-169. ISSN 1097-2765

Bailey, Laura J, Bianchi, Julie, Hegarat, Nadia, Hochegger, Helfrid and Doherty, Aidan J (2015) PrimPol-deficient cells exhibit a pronounced G2 checkpoint response following UV damage. Cell Cycle, 15 (7). pp. 908-918. ISSN 1538-4101

Jozwiakowski, Stanislaw K, Borazjani Gholami, Farimah and Doherty, Aidan J (2015) Archaeal replicative primases can perform translesion DNA synthesis. Proceedings of the National Academy of Sciences, 112 (7). E633-E638. ISSN 0027-8424

Guilliam, Thomas A, Jozwiakowski, Stanislaw K, Ehlinger, Aaron, Barnes, Ryan P, Rudd, Sean G, Bailey, Laura J, Skehel, J Mark, Eckert, Kristin A, Chazin, Walter J and Doherty, Aidan J (2015) Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins. Nucleic Acids Research, 43 (2). pp. 1056-1068. ISSN 0305-1048

Guilliam, Thomas A, Keen, Benjamin A, Brissett, Nigel C and Doherty, Aidan J (2015) Primase-polymerases are a functionally diverse superfamily of replication and repair enzymes. Nucleic Acids Research, 43 (14). pp. 6651-6664. ISSN 0305-1048

Hentges, Pierre, Waller, Helen Rachel, Reis, Clara C, Ferreira, Miguel Godinho and Doherty, Aidan J (2014) Cdk1 restrains NHEJ through phosphorylation of XRCC4-like factor Xlf1. Cell Reports, 9 (6). pp. 2011-2017. ISSN 2211-1247

Jozwiakowski, Stanislaw A, Keith, Brian J, Gilroy, Louise, Doherty, Aidan J and Connolly, Bernard A (2014) An archaeal family-B DNA polymerase variant able to replicate past DNA damage: occurrence of replicative and translesion synthesis polymerases within the B family. Nucleic Acids Research, 42 (15). pp. 9949-9963. ISSN 0305-1048

Rasheduzzaman, Chowdhury, Brissett, Nigel, Krojer, Tobias, Ho, Chia-hua, Ng, Stanley S, Clifton, Ian J, Ge, Wei, Kershaw, Nadia J, Fox, Gavin C, Muniz, Joao R C, Vollmar, Melanie, Phillips, Claire, Pilka, Ewa S, Kavanagh, Kathryn L, von Delft, Frank, Oppermann, Udo, McDonough, Michael A, Doherty, Aidan and Schofield, Christopher J (2014) Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature, 510 (7505). pp. 422-426. ISSN 0028-0836

Rudd, Sean G, Bianchi, Julie and Doherty, Aidan J (2014) PrimPol—A new polymerase on the block. Molecular and Cellular Oncology, 1 (2). a960754 1-10. ISSN 2372-3556

Kuron, Aneta, Korycka-Machala, Malgorzata, Brzostek, Anna, Nowosielski, Marcin, Doherty, Aidan, Dziadek, Bożena and Dziadek, Jaroslaw (2014) Evaluation of DNA primase DnaG as a potential target for antibiotics. Antimicrobial Agents and Chemotherapy, 58 (3). pp. 1699-1706. ISSN 1098-6596

Keen, Benjamin A, Bailey, Laura, Jozwiakowski, Stanislaw and Doherty, Aidan J (2014) Human PrimPol mutation associated with high myopia has a DNA replication defect. Nucleic Acids Research, 42 (19). pp. 12102-12111. ISSN 0305-1048

Keen, Benjamin A, Jozwiakowski, Stanislaw K, Bailey, Laura J, Bianchi, Julie and Doherty, Aidan J (2014) Molecular dissection of the domain architecture and catalytic activities of human PrimPol. Nucleic Acids Research, 42 (9). pp. 5830-5845. ISSN 0305-1048

Rudd, Sean G, Glover, Lucy, Jozwiakowski, Stanislaw K, Horn, David and Doherty, Aidan J (2013) PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the African trypanosome. Molecular Cell, 52 (4). pp. 554-565. ISSN 1097-2765

Bianchi, Julie, Rudd, Sean G, Jozwiakowski, Stanislaw K, Bailey, Laura J, Soura, Violetta, Taylor, Elaine, Stevanovic, Irena, Green, Andrew J, Stracker, Travis H, Lindsay, Howard D and Doherty, Aidan J (2013) PrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replication. Molecular Cell, 52 (4). pp. 566-573. ISSN 1097-2765

Brissett, Nigel C, Martin, Maria J, Bartlett, Edward J, Bianchi, Julie, Blanco, Luis and Doherty, Aidan J (2013) Molecular basis for DNA double-strand break annealing and primer extension by a NHEJ DNA polymerase. Cell Reports, 5 (4). pp. 1108-1120. ISSN 2211-1247

Bartlett, Edward, Brissett, Nigel C and Doherty, Aidan J (2013) Ribonucleolytic resection is required for repair of strand displaced nonhomologous end-joining intermediates. Proceedings of the National Academy of Sciences, 110 (22). E1984-E1991. ISSN 1091-6490

Brissett, Nigel C, Martin, Maria J, Pitcher, Robert S, Bianchi, Julie, Juarez, Raquel, Green, Andrew J, Fox, Gavin C, Blanco, Luis and Doherty, Aidan J (2011) Structure of a preternary complex involving a prokaryotic NHEJ DNA polymerase. Molecular Cell, 41 (2). pp. 221-231. ISSN 1097-2765

Pitcher, R. S., Green, A. J., Brzostek, A., Korycka-Machala, M., Dziadek, J. and Doherty, Aidan (2007) NHEJ protects mycobacteria in stationary phase against the harmful effects of desiccation. DNA Repair, 6 (9). pp. 1271-1276. ISSN 0144-8420

Pitcher, R S, Brissett, N, Picher, A J, Andrade, P, Juarez, R, Thompson, D, Fox, G C, Blanco, L and Doherty, A J (2007) Structure and Function of a Mycobacterial NHEJ DNA Repair Polymerase. Journal of Molecular Biology, 366 (2). pp. 391-405. ISSN 0022-2836

Malyarchuk, Svitlana, Wright, Douglas, Castore, Reneau, Klepper, Emily, Weiss, Bernard, Doherty, Aidan J and Harrison, Lynn (2007) Expression of Mycobacterium tuberculosis Ku and Ligase D in Escherichia coli results in recA-independent DNA end-joining at regions of microhomology. DNA repair, 6 (10). pp. 1413-1424. ISSN 1568-7864

Pitcher, Robert S, Brissett, Nigel C and Doherty, Aidan J (2007) Nonhomologous end-joining in bacteria: a microbial perspective. Annual Review of Microbiology, 61. pp. 258-282. ISSN 0066-4227

Pitcher, Robert S, Tonkin, Louise M, Daley, James M, Palmbos, Phillip L, Green, Andrew, Velting, Tricia L, Brzostek, Anna, Korycka-Machala, Malgorzata, Cresawn, Steve, Dziadek, Jaroslaw, Hatfull, Graham F, Wilson, Thomas E and Doherty, Aidan J (2006) Mycobacteriophage exploit NHEJ to facilitate genome circularization. Molecular Cell, 23 (5). pp. 743-748. ISSN 1097-2765

Palecek, J., Vidot, Susanne, Feng, M., Doherty, A. J. and Lehmann, A. R. (2006) The SMC5-6 DNA repair complex: bridging of the SMC5-6 heads by the Kleisin, NSE4, and non-Kleisin subunits. Journal of Biological Chemistry, 2006 D (48). pp. 36952-36959. ISSN 0021-9258

Boisvert, François-Michel, Rhie, Alexandre, Richard, Stéphane and Doherty, Aidan J (2005) The GAR motif of 53BP1 is arginine methylated by PRMT1 and is necessary for 53BP1 DNA binding activity. Cell Cycle, 4 (12). pp. 1834-1841. ISSN 1538-4101

Chavali, Gayatri B, Ekblad, Caroline M S, Basu, Balaka P, Brissett, Nigel C, Veprintsev, Dmitry, Hughes-Davies, Luke, Kouzarides, Tony, Itzhaki, Laura S and Doherty, Aidan J (2005) Crystal structure of the ENT domain of human EMSY. Journal of Molecular Biology, 350 (5). pp. 964-973. ISSN 0022-2836

Gissen, Paul, Johnson, Colin A, Gentle, Dean, Hurst, Laurence D, Doherty, Aidan J, O'Kane, Cahir J, Kelly, Deirdre A and Maher, Eamonn R (2005) Comparative evolutionary analysis of VPS33 homologues: genetic and functional insight. Human Molecular Genetics, 14 (10). pp. 1261-1270. ISSN 0964-6906

Gissen, Paul, Johnson, Colin A., Gentle, Dean, Hurst, Laurence D., Doherty, Aidan J., O'Kane, Cahir J., Kelly, Deirdre A. and Maher, Eamonn R. (2005) Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights. Human Molecular Genetics, 14 (10). pp. 1261-1270. ISSN 0964-6906

Jowsey, Paul A, Doherty, Aidan J and Rouse, John (2004) Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. Journal of Biological Chemistry, 279 (53). pp. 55562-55569. ISSN 0021-9258

Della, Marina, Palmbos, Phillip L, Tseng, Hui-Min, Tonkin, Louise M, Daley, James M, Topper, Leana M, Pitcher, Robert S, Tomkinson, Alan E, Wilson, Thomas E and Doherty, Aidan J (2004) Mycobacterial Ku and ligase proteins constitute a two-component NHEJ repair machine. Science, 306 (5696). pp. 683-685. ISSN 0036-8075

Girard, Pierre-Marie, Kysela, Boris, Härer, Christine J, Doherty, Aidan J and Jeggo, Penny A (2004) Analysis of DNA ligase IV mutations found in LIG4 syndrome patients: the impact of two linked polymorphisms. Human Molecular Genetics, 13 (20). pp. 2369-2376. ISSN 0964-6906

Jowsey, Paul A., Doherty, Aidan and Rouse, John (2004) hPTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionising radiation. Journal of Biological Chemistry, 279 (53). pp. 55562-55569. ISSN 0021-9258

Riballo, E., Kuhne, M., Rief, N., Doherty, Aidan, Smith, G. C. M., Recio, M-J., Reis, C., Dahm, K., Fricke, A., Krempler, A., Parker, A. R., Jackson, S. P., Gennery, A. R., Jeggo, Penny and Lobrich, M. (2004) A pathway of double strand break rejoining dependent upon ATM, Artemis and proteins locating to g-H2AX foci. Molecular Cell, 16. pp. 715-724. ISSN 1097-2765

Iwabuchi, Kuniyoshi, Basu, Balaka Piku, Kysela, Boris, Kurihara, Takayuki, Shibata, Masao, Guan, Deyu, Cao, Yongheng, Hamada, Tomio, Imamura, Kouji, Jeggo, Penny A, Date, Takayasu and Doherty, Aidan J (2003) Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA. Journal of Biological Chemistry, 278 (38). pp. 36487-36495. ISSN 0021-9258

d'Adda di Fagagna, Fabrizio, Weller, Geoffrey R, Doherty, Aidan and Jackson, Stephen P (2003) The Gam protein of bacteriophage Mu is an orthologue of eukaryotic Ku. EMBO Reports, 4 (1). pp. 47-52. ISSN 1469-221X

Derbyshire, D J, Basu, B P, Date, T, Iwabuchi, K and Doherty, A J (2002) Purification, crystallization and preliminary X-ray analysis of the BRCT domains of human 53BP1 bound to the p53 tumour suppressor. Acta Crystallographica Section D: Biological Crystallography, 58 (10). pp. 1826-9. ISSN 0907-4449

Weller, Geoffrey R, Kysela, Boris, Roy, Rajat, Tonkin, Louise M, Scanlan, Elizabeth, Della, Marina, Devine, Susanne Krogh, Day, Jonathan P, Wilkinson, Adam, d'Adda di Fagagna, Fabrizio, Devine, Kevin M, Bowater, Richard P, Jeggo, Penny, Jackson, Stephen P and Doherty, Aidan J (2002) Identification of a DNA nonhomologous end-joining complex in bacteria. Science, 297 (5587). pp. 1686-9. ISSN 1095-9203

Weller, Geoffery R, Kysela, Boris, Roy, Rajat, Tonkin, Louise M, Scanlan, Elizabeth, Della, Marina, Devine, Susanne Krogh, Day, Jonathan P, Wilkinson, Adam, d'Adda di Fagagna, Fabrizio, Devine, Kevin M, Bowater, Richard P, Jeggo, Penny A, Jackson, Stephen P and Doherty, Aidan J (2002) Identification of a DNA nonhomologous end-joining complex in bacteria. Science, 297. pp. 1686-1689. ISSN 0036-8075

Dionne, Isabelle, Nookala, Ravi K, Jackson, Stephen P, Doherty, Aidan D and Bell, Stephen D (2001) A heterotrimeric PCNA in the hyperthermophilic archaeon Sulfolobus solfataricus. Molecular Cell, 11 (1). pp. 275-82. ISSN 1097-2765

Book Section

Bartlett, E J and Doherty, A J (2012) Nonhomologous end joining in bacteria. In: Encyclopedia of Biological Chemistry: Second Edition. Elsevier, Amsterdam, pp. 266-268. ISBN 9780123786302

Brissett, N.C., Martin, M.J., Pitcher, R.S.,Green, A.J., Juarez, R., Fox, G.C., Blanco, L. & Doherty, A.J. (2011) Structure of a pre-ternary complex involving a prokaryotic NHEJ polymerase.
Mol. Cell 41, 221-231
 
Bailey, S.G., Verrall E., Schelcher C., Rhie A., Doherty A.J., Sinclair A.J. (2009) Functional Interaction Between Epstein-Barr Virus Replication Protein Zta and Host DNA-Damage Response Protein 53BP1.
J. Virol. 83, 11116-11122.
 
Brissett N.C. & Doherty A.J. (2009) Repairing DNA double-strand breaks by the prokaryotic non-homologous end-joining pathway.
Biochem. Soc. Trans. 37, 539-545.
 
Eliezer, Y., Argaman, L., Rhie, A., Doherty, A.J. & Goldberg, M. (2009) The direct interaction between 53BP1 and MDC1 is required for the recruitment of 53PB1 to sites of damage.
J. Biol. Chem. 284, 426-435.
 
Brissett, N.C., Pitcher, R.S. Picher, A.J., Andrade, P. Juarez, R.,  Green, A.J., Dafforn, T., D. Fox, G.C., Blanco, L. & Doherty, A.J. (2007)  Structure of a polymerase-mediated DNA NHEJ synaptic complex
Science 318, 456-459.
 
Malyarchuk, S., Wright, D., Castore, R., Klepper, E., Weiss, B. , Doherty, A.J. & Harrison, L. (2007) Expression of Mycobacterium tuberculosis Ku and Ligase D in Escherichia coli results in recA-independent DNA end-joining at regions of microhomology.
DNA repair 6, 1413-1424.

Pitcher, R.S., Brissett, N.C. & Doherty, A.J. (2007) Non Homologous End-Joining in Bacteria:  A Microbial Perspective.
Ann. Rev. Microbiol. 61, 258-282.

Pitcher, R., Green, A.J.,  Brzostek, A., Korycka-Machala, M., Dziadek, J. &  Doherty, A.J.  NHEJ protects Mycobacteria against the harmful effects of desiccation (2007)
DNA Repair 6, 1271-1276.
 
Moeller, R., Stackebrandt, E., Reitz, G., Berger, T., Rettberg, P., Doherty, A.J., Horneck, G., Nicholson, W.L. (2007) Role of DNA repair by non-homologous end joining (NHEJ) in Bacillus subtilis spore resistance to extreme dryness, mono- and polychromatic UV and ionizing radiation.
J. Bacteriol. 189, 3306-3311.
 
Pitcher, R.S. Brissett, N.C. Picher, A.J., Andrade, P. Juarez, R., Thompson, D. Fox, G.C., Blanco, L. & Doherty, A.J. (2007) Structure and Function of a Mycobacterial NHEJ DNA repair polymerase
J. Mol. Biol. 66, 391–405.
 
Bowater, R. & Doherty, A.J. (2006) Making Ends Meet: Repairing Breaks in Bacterial DNA by Non-Homologous End-Joining.
PLOS Genetics 2, e8.
 
Marchetti C., Walker, S.A., Odreman, F., Vindigni, A., Doherty, A.J. & Jeggo, P.
Identification of a novel motif in DNA ligases exemplified by DNA ligase IV. (2006)
DNA Repair 5, 788-98. 
 
Pitcher, R.S., Tonkin, L.M.,  Daley,  J.M., Palmbos,  P.L., Green, A.J.,  Velting, T.L., Brzostek, A.,  Korycka-Machala, M.,Cresawn, S.,  Dziadek, J.,  Hatfull, G.F.,  Wilson,  T.E. &  Doherty, A.J.  (2006) Mycobacteriophage Exploit NHEJ to Facilitate Genome Circularization 
Mol. Cell 23, 743-748.

Palecek, J., Vidot, S., Feng, M., Doherty, A.J. & Lehmann, A.R. (2006) Nse4 is the kleisin component of the Smc5-6 DNA repair complex.
J. Biol. Chem. 281, 36952–36959
 
Hentges, P., Ahnesorg, P., Pitcher, R.S., Bruce, C.K., Kysela, B., Green, A.J., Bianchi, J. Wilson, T.E., JacksonS.P. & Doherty, A.J. (2006) Evolutionary and Functional Conservation of the DNA Non homologous End‑joining Protein, XLF/Cernunnos.
J. Biol. Chem. 281, 37517–37526.
 
Chavali, G., Ekblad, C., Basu, B.P., Brissett, N., Hughes-Davies, L., Kouzarides, T., Itzaki, L, Doherty, A.J.
Crystal structure of the ENT domain of EMSY. (2005)
J. Mol. Biol. 350, 964-973.
 
Ekblad, C., Chavali, G., Basu, B.P., Freund, S.M.V., Veprintsev, D. Hughes-Davies, L., Kouzarides, T., Doherty, A.J. and Itzaki, L. (2005) The binding of EMSY to HP1: Implications for recruitment of HP1 and BS69. 
EMBO Rep.  6, 675-680.
 
Pitcher, R.S., Tonkin, L.M., Green, A.J. & Doherty, A.J. (2005) Domain Structure of a NHEJ DNA Repair Ligase from Mycobacterium tuberculosis.
J. Mol. Biol. 351, 531-544.
 
Boisvert, F.M., Rhie, A., .Richard, S.& Doherty, A.J. (2005) The GAR motif of 53BP1 is a target for PRMT1 methylation and directs chromatin localisation in response to DNA damage.
Cell Cycle 4, 1834-1841.

Riballo, E. et al., Doherty, A.J. et al. Jeggo, P. & Lobrich, M. (2004) A pathway of double strand break rejoining dependent upon ATM, Artemis and proteins locating to gamma-H2AX foci. 
Mol. Cell 16, 715-724.

Jowsey, P.A., Doherty, A.J. & Rouse, J.  (2004) hPTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionising radiation. 
J. Biol Chem. 279, 55562-55569.

Della, M. et al. & Doherty, A.J. (2004) Mycobacterial Ku and Ligase proteins constitute a two-component NHEJ repair machine.

Science 306, 683-685.

Dionne, I. Nookala, R., Jackson, S.P.,  Doherty, A.J & Bell S.D. (2003)
The heterotrimeric PCNA of the hyperthermophilic archaeon Sulfolobus solfatricus: implications for the clamp loading mechanism. 
Mol. Cell 11, 275-282.
 
D’Adda di Fagagna, F., Weller, G.R., Doherty, A.J. &  Jackson, S.P. (2003)
The Gam protein of phage Mu is an orthologue of eukaryotic Ku. 
EMBO Rep. 1, 47-52.
 
Doherty, A.J. &  Jackson, S.P. (2002) How Ku makes ends meet.
Current Biol 11, R920-R924.
 
Derbyshire, D.J., Basu, B.P., Joo. W.S., Iwabuchi, K. & Doherty, A.J. (2002) Crystal Structure of the BRCT Domains of Human 53BP1 Bound to the p53 Tumor Suppressor.
EMBO J. 21, 3863-3872.

Weller, G.R., Kysella, B., Roy, R., Tonkin, L., Scanlan, E., Della, M., Devine, S.K., J.P., Day, J.P.   Wilkinson, A., d'Adda di Fagagna, F., Devine, K., Bowater, R., Jeggo, P.A. Jackson, S.P.  Doherty, A.J. (2002) Identification of a DNA non-homologus end-joining complex in bacteria.

Science 297 ,1686-1689