20 Selected Publications 2001-2024

Professor Keith W Caldecott

Gautam A, Fawcett H, Burdova K, Brazina J, Caldecott KW. APE1-dependent base excision repair of DNA photodimers in human cells. Molecular Cell. 2023; 83:3669-3678

Serrano-Benitez A, Wells SE, Drummond-Clarke L, Russo LC, Thomas JC, Leal GA, Farrow M, Edgerton JM, Balasubramanian S, Yang M, Frezza C, Gautam A, Brazina J, Burdova K, Hoch NC, Jackson SP, Caldecott KW. Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity. EMBO J. 2023 ;42 :e113190. 

Vaitsiankova A, Burdova K, Sobol M, Gautam A, Benada O, Hanzlikova H, Caldecott KW (2022). PARP inhibition impedes the maturation of nascent DNA strands during DNA replication. Nat Struct Mol Biol. 29:329-338. 

Adamowicz M, Hailstone R, Demin AA, Komulainen E, Hanzlikova H, Brazina J, Gautam A, Wells SE, Caldecott KW (2021). XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair. Nature Cell Biology 23:1287-1298.

Demin A.A, Hirota K, Tsuda M,Adamowicz M,Hailstone R,Brazina J,Gittens W,Kalasova I, Shao Z, Zha S,Sasanuma S, Hanzlikova H,Takeda S*,Caldecott K* (2021). XRCC1 prevents toxic PARP1 trapping during DNA base excision repair. Molecular Cell. 81; 1–13. *co-corresponding authors

Wu W, Hill SE, Nathan WJ, Paiano J, Callen E, Wang D, Shinoda K, van Wietmarschen N, Colón-Mercado JM, Zong D, De Pace R, Shih HY, Coon S, Parsadanian M, Pavani R, Hanzlikova H, Park S, Jung SK, McHugh PJ, Canela A, Chen C, Casellas R, Caldecott KW*, Ward ME*, Nussenzweig A*. (2021) Neuronal enhancers are hotspots for DNA single-strand break repair. Nature. 593:440-444. *Co-corresponding authors

Hanzlikova H, Kalasova I, Demin A.A, Penicott L.E., Cihlarova Z., Caldecott K.W. (2018).The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication. Molecular Cell. 71;1-13, 

Gómez-Herreros F, Zagnoli-Vieira G, Ntai N, Martínez-Macías MI, Anderson RM, Herrero-Ruíz A & Caldecott KW. (2017). TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription. Nature Communications. 8: 233 

Hoch N*, HanzlikovaH*, RultenSL, Tétreault M, Koumulainen E, Limei Ju, Hornyak P, Zeng Z, Gittens W, Rey S, Staras K, Mancini GMS, McKinnon PJ, Wang ZQ, Wagner J, Yoon G** and Caldecott KW**. (2017). XRCC1 Mutation is Associated with PARP1 Hyperactivation and Cerebellar Ataxia. Nature. 5; 541:87-91. *co-first authors **co-corresponding author

Gómez-Herreros F, Schuurs-Hoeijmakers JH, McCormack M, Greally MT, Rulten S, Romero-Granados R, Counihan TJ, Chaila E, Conroy J, Ennis S, Delanty N, Cortés-Ledesma F, de Brouwer AP, Cavalleri GL, El-Khamisy SF, de Vries BB, Caldecott KW. (2014).TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function. Nature Genetics. 46, 516-521.

Stuart L. Rulten, Anna E.O.Fisher, Isabelle Robert, Maria C. Zuma, Michele Rouleau, Limei Ju, Guy Poirier^, Bernardo Reina-San-Martin, and Keith W. Caldecott. (2011). PARP-3 and APLF Function Together to Accelerate Non-Homologous End Joining. Molecular Cell. 41, 33-45.

Felipe Cortes-Ledesma, Sherif F. El Khamisy, Maria C. Zuma, Kay Osborn, and Keith W. Caldecott^.. (2009). A Human 5’-Tyrosyl DNA Phosphodiesterase That Repairs Topoisomerase-Mediated DNA Damage. Nature. 461, 674-678.  

Lee Y, Katyal S, Li Y, El-Khamisy SF, Russell HR, Caldecott KW, McKinnon PJ.(2009). The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1. Nature Neuroscience.12:973-80. 

Ahel I, Rass U, El-Khamisy SF, Katyal S, Clements PM, McKinnon PJ, Caldecott KW, West SC. (2006). The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature. 443:713-6. 

El-Khamisy,S.F., Gulam M. Saifi, Michael Weinfeld, Fredrik Johansson, Thomas Helleday, James R. Lupski, and Keith W. Caldecott. (2005). Defective DNA Single-Strand Break Repair in Spinocerebellar Ataxia with Axonal Neuropathy-1. Nature. 434; 108-113

Loizou JI, El-Khamisy SF, Zlatanou A, Moore DJ, Chan DW, Qin J, Sarno S, Meggio F, Pinna LA, Caldecott KW. (2004). The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks. Cell.117:17-28. 

Henry-Mowatt J, Jackson D, Masson JY, Johnson PA, Clements PM, Benson FE,Thompson LH, Takeda S, West SC, Caldecott KW.  (2003). XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes. Molecular Cell. 4:1109-17. 

Caldecott KW. DNA single-strand break repair and spinocerebellar ataxia. Cell (2003);112:7-10. 

Whitehouse CJ, Taylor RM, Thistlethwaite A, Zhang H, Karimi-Busheri F, Lasko DD, Weinfeld M, Caldecott KW.  (2001). XRCC1 stimulates PNK activity at damaged DNA termini and accelerates DNA single-strand break repair. Cell. 104:107-17.