Baxter Lab

Publications

2024

  • Keszthelyi, A., Mansoubi, S., Whale, A., Houseley, J., & Baxter, J. (2024). The fork protection complex generates DNA topological stress-induced DNA damage while ensuring full and faithful genome duplication.. Proceedings of the National Academy of Sciences of the United States of America, 121(49), e2413631121. doi:10.1073/pnas.2413631121
    Article. View online.
  • Baxter, J. (2024). Entangling and disentangling mitotic chromosomes. Molecular Cell, 84(8), 1398-1400. doi:10.1016/j.molcel.2024.03.025
    Article. View on figshare.
  • Cameron, G., Gruszka, D. T., Gruar, R., Xie, S., Kaya, Ç., Nasmyth, K. A., . . . Yardimci, H. (2024). Sister chromatid cohesion establishment during DNA replication termination. Science, 384(6691), 119-124. doi:10.1126/science.adf0224
    Article. View on figshare.

2023

  • Keszthelyi, A., Whale, A., Houseley, J., & Baxter, J. (2023). The Fork Protection Complex protects long replicons from DNA damage at the cost of genome instability induced by DNA topological stress. doi:10.1101/2023.08.04.551986
    Preprint. View online.

2022

  • Hallett, S., Harry, I. C., Schellenberger, P., Zhou, L., Cronin, N. B., Baxter, J., . . . Oliver, A. (2022). Cryo-EM Structure of the Smc5/6 holocomplex. Nucleic Acids Research, 50(16), 9505-9520. doi:10.1093/nar/gkac692
    Article. View on figshare.
  • Pandey, S., Hajikazemi, M., Zacheja, T., Schalbetter, S., Neale, M., Baxter, J., . . . Paeschke, K. (2022). Author Correction to: Telomerase subunit Est2 marks internal sites that are prone to accumulate DNA damage (BMC Biology, (2021), 19, 1, (247), 10.1186/s12915-021-01167-1). BMC Biology, 20(1), pages. doi:10.1186/s12915-022-01237-y
    Article. View on figshare.

2021

  • Pandey, S., Hajikazemi, M., Zacheja, T., Schalbetter, S., Neale, M., Baxter, J., . . . Paeschke, K. (2021). Telomerase subunit Est2 marks internal sites that are prone to accumulate DNA damage. BMC Biology, 19(1), pages. doi:10.1186/s12915-021-01167-1
    Article. View on figshare.
  • Hallett, S., Harry, I. C., Schellenberger, P., Zhou, L., Cronin, N., Baxter, J., . . . Oliver, A. (2021). Cryo-EM structure of the Smc5/6 holo-complex. doi:10.1101/2021.11.25.470006
    Preprint. View online.

2020

  • Westhorpe, E., Keszthelyi, A., Minchell, N., Jones, D., & Baxter, J. (2020). Separable functions of Tof1/Timeless in intra-S-checkpoint signalling, replisome stability and DNA topological stress. Nucleic Acids Research, 48(21), 12169-12187. doi:10.1093/nar/gkaa963
    Article. View on figshare.
  • Paldi, F., Alver, B., Robertson, D., Schalbetter, S. A., Kerr, A., Kelly, D. A., . . . Marston, A. L. (2020). Convergent genes shape budding yeast pericentromeres. Nature, 582, 119-123. doi:10.1038/s41586-020-2244-6
    Article. View on figshare.
  • Minchell, N. E., Keszthelyi, A., & Baxter, J. (2020). Cohesin causes replicative DNA damage by trapping DNA topological stress. Molecular cell, 78(4), 739-751. doi:10.1016/j.molcel.2020.03.013
    Article. View on figshare.

2019

  • Morafraile, E. C., Hänni, C., Allen, G., Zeisner, T., Clarke, C., Johnson, M. C., . . . Zegerman, P. (2019). Checkpoint inhibition of origin firing prevents DNA topological stress. Genes & development, 33(21-22), 1539-1554. doi:10.1101/gad.328682.119
    Article. View online.
  • Schalbetter, S. A., Fudenberg, G., Baxter, J., Pollard, K. S., & Neale, M. (n.d.). Principles of meiotic chromosome assembly revealed in S. cerevisiae. Nature Communications, 10, pages. doi:10.1038/s41467-019-12629-0
    Article. View on figshare.
  • Deegan, T. D., Baxter, J., Bazán, M. Á. O., Yeeles, J. T. P., & Labib, K. P. M. (2019). Pif1-Family helicases support fork convergence during DNA replication termination in eukaryotes. Molecular Cell, 74(2), 231-244.e9. doi:10.1016/j.molcel.2019.01.040
    Article. View on figshare.
  • Schalbetter, S. A., & Baxter, J. (2019). Preparation of cell cycle-synchronized saccharomyces cerevisiae cells for Hi-C. Unknown Journal, 2004, 155-165. doi:10.1007/978-1-4939-9520-2_12
    Article. View online.
  • Paldi, F., Alver, B., Robertson, D., Schalbetter, S., Kerr, A., Kelly, D., . . . Marston, A. (2019). Convergent genes shape budding yeast pericentromeres. doi:10.1101/592782
    Article. View online.
  • Westhorpe, R., Keszthelyi, A., Minchell, N., Jones, D., & Baxter, J. (2019). Separable functions of Tof1/Timeless in intra-S-checkpoint signalling, replisome stability and DNA topological stress. doi:10.1101/2019.12.17.877811
    Article. View online.

2018

  • Baxter, J., Oliver, A., & Schalbetter, S. A. (2019). Are SMC complexes loop extruding factors? Linking theory with fact. BioEssays, 41(1), 1800182 1-10. doi:10.1002/bies.201800182
    Article. View on figshare.
  • Schalbetter, S., Fudenberg, G., Baxter, J., Pollard, K., & Neale, M. (2018). Principles of Meiotic Chromosome Assembly. doi:10.1101/442038
    Preprint. View online.

2017

  • Schalbettertter, S. A., Goloborodko, A., Fudenberg, G., Belton, J. -M., Miles, C., Yu, M., . . . Baxter, J. (2017). SMC complexes differentially compact mitotic chromosomes according to genomic context. Nature Cell Biology, 19(9), 1071-1080. doi:10.1038/ncb3594
    Article. View on figshare.

2016

  • Keszthelyi, A., Minchell, N., & Baxter, J. (2016). The causes and consequences of topological stress during DNA replication. Genes, 7(12), 134 ( pages). doi:10.3390/genes7120134
    Article. View on figshare.
  • Schalbetter, S. A., Goloborodko, A., Fudenberg, G., Belton, J. M., Miles, C., Yu, M., . . . Baxter, J. (2016). Cohesin dependent compaction of mitotic chromosomes. doi:10.1101/094946
    Preprint. View online.

2015

  • Schalbetter, S. A., Mansoubi, S., Chambers, A. L., Downs, J. A., & Baxter, J. (2015). Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability. Proceedings of the National Academy of Sciences, 112(33), pages. doi:10.1073/pnas.1505356112
    Article. View on figshare.

2014

  • Baxter, J. (2014). “Breaking up is hard to do”: the formation and resolution of sister chromatid intertwines. Journal of Molecular Biology, 427(3), 590-607. doi:10.1016/j.jmb.2014.08.022
    Article. View on figshare.

2012

  • Baxter, J. (2012). A model for chromosome condensation based on the interplay between condensin and topoisomerase II. Trends in Genetics, 28(3), 110-117. doi:10.1016/j.tig.2011.11.004
    Article. View on figshare.

2011

  • Baxter, J., Sen, N., Martínez, V. L., De Carandini, M. E. M., Schwartzman, J. B., Diffley, J. F. X., & Aragón, L. (2011). Positive supercoiling of mitotic DNA drives decatenation by topoisomerase II in eukaryotes. Science, 331(6022), 1328-32. doi:10.1126/science.1201538
    Article. View on figshare.
  • Baxter, J., & Aragón, L. (2011). Physical Linkages between Sister Chromatids and Their Removal during Yeast Chromosome Segregation. Cold Spring Harbor Symposia on Quantitative Biology, pages.
    Article. View on figshare.

2008

  • Baxter, J., & Diffley, J. F. X. (2008). Topoisomerase II inactivation prevents the completion of DNA replication in budding yeast. Molecular Cell, 30(6), 790-802. doi:10.1016/j.molcel.2008.04.019
    Article. View on figshare.

2004

  • Baxter, J., Sauer, S., Peters, A., John, R., Williams, R., Caparros, M. L., . . . Fisher, A. G. (2004). Histone hypomethylation is an indicator of epigenetic plasticity in quiescent lymphocytes. EMBO Journal, 23(22), 4462-4472. doi:10.1038/sj.emboj.7600414
    Article. View online.

2002

  • Mak, W., Baxter, J., Silva, J., Newall, A. E., & Otte, A. P. (2002). Mitotically stable association of polycomb group proteins Eed and Enx1 with the inactive X chromosome in trophoblast stem cells. Current Biology, 12(12), 1016-1020. doi:10.1016/S0960-9822(02)00892-8
    Article. View online.
  • Baxter, J., Merkenschlager, M., & Fisher, A. G. (2002). Nuclear organisation and gene expression. Current Opinion in Cell Biology, 14(3), 372-376. doi:10.1016/S0955-0674(02)00339-3
    Article. View online.

2001

  • Skok, J. A., Brown, K. E., Azuara, V., Caparros, M. L., Baxter, J., Takacs, K., . . . Fisher, A. G. (2001). Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes. Nature Immunology, 2(9), 848-854. doi:10.1038/ni0901-848
    Article. View online.

1999

  • Brown, K. E., Baxter, J., Graf, D., Merkenschlager, M., & Fisher, A. G. (1999). Dynamic repositioning of genes in the nucleus of lymphocytes preparing for cell division. Molecular Cell, 3(2), 207-217. doi:10.1016/S1097-2765(00)80311-1
    Article. View online.

Unpublished works

  • Minchell, N., Keszthelyi, A., & Baxter, J. (n.d.). SMC Complexes Cause Replicative DNA Damage by Trapping DNA Topological Stress. doi:10.2139/ssrn.3444606
    Preprint. View online.
 

Baxter, J.*, Sen, N., Martinez, V.L., De Carandini, M.E., Schvartzman, J.B., Diffley, J.F., and Aragon, L.* (2011). Positive supercoiling of mitotic DNA drives decatenation by topoisomerase II in eukaryotes. Science 331, 1328-1332.

 

Baxter, J. and Aragon, L.* (2011). Physical Linkages between Sister Chromatids and Their Removal during Yeast Chromosome Segregation. Cold Spring Harb Symp Quant Biol. Jan 5.

 

Baxter, J. and Diffley, J.F.* (2008). Topoisomerase II inactivation prevents the completion of DNA replication in budding yeast. Molecular cell 30, 790-802.

 

Baxter, J., Sauer, S., Peters, A., John, R., Williams, R., Caparros, M.L., Arney, K., Otte, A., Jenuwein, T., Merkenschlager, M. and Fisher, A.G* (2004). Histone hypomethylation is an indicator of epigenetic plasticity in quiescent lymphocytes. The EMBO journal 23, 4462-4472.

 

Baxter, J., Merkenschlager, M. and Fisher, A.G. (2002). Nuclear organisation and gene expression. Current Opinions in Cell Biology 14, 372-376.

 

Mak, W., Baxter, J., Silva, J., Newall, A.E., Otte, A.P. and Brockdorff, N.* (2002). Mitotically stable association of polycomb group proteins eed and enx1 with the inactive x chromosome in trophoblast stem cells. Current Biology 12, 1016-1020.

 

Skok, J.A., Brown, K.E., Azuara, V., Caparros, M.L., Baxter, J., Takacs, K., Dillon, N., Gray, D., Perry, R.P., Merkenschlager, M. and Fisher, A.G.* (2001). Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes. Nature Immunology 2, 848-854.

 

Brown, K.E., Baxter, J., Graf, D., Merkenschlager, M. and Fisher, A.G.* (1999). Dynamic repositioning of genes in the nucleus of lymphocytes preparing for cell division. Molecular cell 3, 207-217.

Article

Westhorpe, Rose, Keszthelyi, Andrea, Minchell, Nicola E, Jones, David and Baxter, Jonathan (2020) Separable functions of Tof1/Timeless in intra-S-checkpoint signalling, replisome stability and DNA topological stress. Nucleic Acids Research, 48 (21). pp. 12169-12187. ISSN 0305-1048

Minchell, Nicola Elizabeth, Keszthelyi, Andrea and Baxter, Jonathan (2020) Cohesin causes replicative DNA damage by trapping DNA topological stress. Molecular cell, 78 (4). pp. 739-751. ISSN 1097-2765

Paldi, Flora, Alver, Bonnie, Robertson, Daniel, Schalbetter, Stephanie A, Kerr, Alastair, Kelly, David A, Baxter, Jonathan, Neale, Matthew J and Marston, Adele L (2020) Convergent genes shape budding yeast pericentromeres. Nature, 582. pp. 119-123. ISSN 0028-0836

Deegan, Tom D, Baxter, Jonathan, Ortiz Bazán, María Ángeles, Yeeles, Joseph T P and Labib, Karim P M (2019) Pif1-Family helicases support fork convergence during DNA replication termination in eukaryotes. Molecular Cell, 74 (2). 231-244.e9. ISSN 1097-4164

Baxter, Jonathan, Oliver, Antony W and Schalbetter, Stephanie A (2019) Are SMC complexes loop extruding factors? Linking theory with fact. BioEssays, 41 (1). 1800182 1-10. ISSN 1521-1878

Schalbettertter, Stephanie Andrea, Goloborodko, Anton, Fudenberg, Geoffrey, Belton, Jon-Matthew, Miles, Catrina, Yu, Miao, Dekker, Job, Mirny, Leonid and Baxter, Jonathan (2017) SMC complexes differentially compact mitotic chromosomes according to genomic context. Nature Cell Biology, 19 (9). pp. 1071-1080. ISSN 1465-7392

Keszthelyi, Andrea, Minchell, Nicola and Baxter, Jon (2016) The causes and consequences of topological stress during DNA replication. Genes, 7 (12). p. 134. ISSN 2073-4425

Schalbetter, Stephanie A, Mansoubi, Sahar, Chambers, Anna L, Downs, Jessica A and Baxter, Jonathan (2015) Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability. Proceedings of the National Academy of Sciences, 112 (33). E4565-E4570. ISSN 0027-8424

Baxter, Jonathan (2014) “Breaking up is hard to do”: the formation and resolution of sister chromatid intertwines. Journal of Molecular Biology, 427 (3). pp. 590-607. ISSN 0022-2836

Baxter, Jon (2012) A model for chromosome condensation based on the interplay between condensin and topoisomerase II. Trends in Genetics, 28 (3). pp. 110-117. ISSN 0168-9525

Baxter, J, Sen, N, López Martínez, V, Monturus De Carandini, M E, Schwartzman, J B, Diffley, J F X and Aragón, L (2011) Positive supercoiling of mitotic DNA drives decatenation by topoisomerase II in eukaryotes. Science, 331 (6022). pp. 1328-32. ISSN 0036-8075

Baxter, J and Aragón, L (2011) Physical Linkages between Sister Chromatids and Their Removal during Yeast Chromosome Segregation. Cold Spring Harbor Symposia on Quantitative Biology. ISSN 0091-7451

Baxter, Jonathan and Diffley, John F X (2008) Topoisomerase II inactivation prevents the completion of DNA replication in budding yeast. Molecular Cell, 30 (6). pp. 790-802. ISSN 1097-2765