Annual meeting of the Association of Radiation Research 2014


ARR 2014 Provisional Programme
Fulton Building
University of Sussex
Brighton BN1 9RQ

contact: Penny Jeggo or

Sunday 29th June

4.30 - 6.30 pm Arrival and registration: GDSC Building, University of Sussex

Monday 30th June

9.00 -10.15 am Arrival and registration: Fulton Building, University of Sussex
Session 1
10.15 - 12.30pm DNA repair and chromatin changes
10.15-11.00am Opening speaker: Steve Jackson, University of Cambridge
  Assembly and disassembly of protein complexes at sites of DNA damage
11.00-11.30am Markus Lobrich, Darmstadt, Germany
  Regulating DNA double-strand break resection during the mammalian cell cycle
11.30-12.00am Kienan Savage, Queen's University of Belfast, UK
  A novel BRCA1 associated mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability 
12.00-12.15am Vincenzo D'Angiolella, University of Oxford.
   Insights into Ribonucleotide Reductase (RNR) regulation during cell cycle progression and DNA damage respoonse
12.15-12.30pm  Peter Brownlee, University of Sussex. BAF180 promotes cohesion adn prevents genome instability and aneuploidy.
12.30 - 2.00 lunch + poster viewing
Session 2
2.00 - 3.30pm Cellular effects and imaging approaches
2.00 - 2.45 pm Marco Durante, GSI Helmholtz Center and Technical University of Darmstadt, Germany
  Cellular radiobiology for hypofractionated particle therapy
Talk sponsored by the EACR
2.45 - 3.15 pm Tim Humphrey. University of Oxford.
  Histone H3K36 trimethylation facilitates homologous recombination repair and genome stability.
3.15 - 3.30 pm Rhona Anderson, Brunel University
  DNA DSBs are induced linearly and processed efficiently in non-aged normal human bronchial lung epithelial cells.
3.30 - 4.00pm coffee 
Session 3
4.00 - 5.30pm Tissue effects and response modelling
4.00 - 4.30 pm Helen Bryne, University of Oxford
  Mathematical Modelling: A Potent Weapon for Treating Solid Tumours?
4.30 - 5.00 pm Melda Tozluoglu, UCL UK
  Plassticity of the cancer cell migration: Extracellular matrix drives the optimisation of blebbing, adhesions and spreading
5.00 - 5.30 pm Marion Scharpfenecker, NKI, Amsterdam
  Inflammation in late renal toxicity: friend or foe.

Tuesday 1st July 

Session 4
9.00 - 10.30pm Biomarkers for screening or radiation response identification
9.00 - 9.30am John Waterton, University of Manchester and AstraZeneca, UK
  Imaging biomarkers for early response assessment in cancer therapy
9.30 - 10.00am Kai Rothkamm, PHE
  Cytogenetic and DNA double-strand break biomarkers of radiation exposure and individual radiosensitivity
10.00-10.20am Omid Azimzadeh, Helmholtz Zentrum Munchen, Institute of Radiation Biology, Munich, Germany
  Interaction between cardiac and hepatic proteome after low total body or high local cardiac irradiation using different mouse models
10.20-10.35am Cynthia Eccles, University of Oxford.
  In vivo validation of changes in phospho-Akt in normal tissues following radiosensitisation with Plk3/mTOR inhibitors.
10.30 - 11.00am Coffee  
 Session 5
11.00 - 12.20pm Low doses irradiation and Radiation Protection
11.00-11.30am Mark Pearce, University of Newcastle
  Cancer risks following CT scans in childhood or early adulthood
11.30-12.00am Michael Hauptmann, NKI, The Netherlands 
  What to expect from ongoing European studies of CT-related cancer risks
Talk sponsored by the AICR
12.00-12.30pm Gerry Kendall, University of Oxford 
  Natural ionizing radiation exposure and childhood cancer 
12.30 - 2.00pm Lunch and Poster viewing


Session 6
3.00 - 4.30pm Enhancing radiotherapy. Session sponsored by CTRad
2.00 - 2.30 pm Ester Hammond, Oxford, UK
  Targeting hypoxic tumour cells through the DNA damage response
2.30 - 3.00 pm Marc Vooijs, Maastricht, The Netherlands 
  NOTCH signaling in cancer and therapy resistance 
3.00 - 3.15 pm Christopher Talbot, Leicester University, UK
  The REQUITE project: Validating predictive models and biomarkers of radiotherapy toxicity to reduce side effects and improve quality of life in cancer survivors
 3.15 - 3.30 pm Karl Butterworth, Queen's University of Belfast, UK
  In vitro/in vivo characterisation of radiation induced signallig effects towards biologically optimised radiotherapy.
3.30 - 4.00 pm Coffee
4.00 - 5.30 pm SIT session . Chairs: Pheobe Lam and Jane Bryant.
4.00 - 4.15 pm Dafni-Eleftheria Pefani, Oncology Department, University of Oxford
  RassF1A/Lats1 pathway regulates CDK2-BRCA2 dependent replication fork stability.
 4.15 - 4.30 pm Lara Barazzuol, GDSC, University of Sussex
  DNA damage arises in adult neuronal cells and sensitively activates apoptosis in the subventricular zone stem cell compartment after low dose radiation
 4.30 - 4.45 pm Ann-Sofie Schreurs, NASA, US
  The role of oxidative damage in radiation-induced bone loss.
 4.45 - 5.00 pm Sarah Jevons, Oncology Department, University of Oxford, UK
  Clinically relevant MRE11 variants in bladder cancer. 
 5.00 - 5.15 pm Simon Horn, Queen's University of Belfast, UK
  Alpha particle induced pan nuclear phosphorylation of H2AX and ATM in cells driven through chromatin remodelling. 
5.15 - 5.30 pm  Grainne Manning, Public Health England, UK
  Quantifying murine bone marrow blood radiation dose response following 18F-FDG PET with biomarkers
6.45 pm Drinks reception
7.00 pm  Prior to dinner:
  Mike Atkinson, Munich, Germany– Weiss Medal Award Lecture
  The more we discover, the less we understand: The ever-changing biology of radiation
Sponsorship by ERR
8.00 pm Conference dinner
9.30 pm Dancing to Seaford Rock and Jazz Orchestra

Wednesday 2nd July

Session 7 
9.00 - 10.30am Tumour microenvironment  
9.00 - 9.30 am Ruth Muschel, University of Oxford, UK 
  Tumour-vascular interaction:implications for radiation therapy.  
9.30 - 10.00am Andy Ryan, University of Oxford, UK 
  The influence of microenvironment on the antitumour effects of PARP inhibition in combination with radiation
10.00-10.15 am Iosifina Foskolou, University of Oxford, UK
  RRM2B: oxygen-requiring protein induced in hypoxia
10.00-10.30 am Kaye Williams, University of Manchester, UK
  Analysing the effects of radiotherapy on the metastic phenotype in vivo: A role for combined therapeutic approaches incorporating Src and PI3K targeting.
10.30 - 11.00am Coffee
Session 8
11.00 - 12.30pm Nuclear Medicine.
11.00-11.30am Kate Vallis, Oxford University, UK
  Radionuclide imaging and therapy using targeted nano particles
11.30-12.00am Jonathan Coulter, School of Pharmacy, Belfast

Enhanced radiation sensitivity using antagonistic, lipophilic pepducins: opportunities for novel radiosensitisers.

12.00-12.15pm Munira Kadhim, Oxford Brrokes University.
  Non-targeted effects of Ionizing radiation: Recent advance in understanding the mechanisms and impacts
12.15-12.30pm Mark Hill, University of Oxford.
  The anatomy of an alpha-particle track and implications for biological response.
12.30 - 2.30pm Lunch and poster viewing
Session 9
2.30 - 4.15pm Stem cells
2.30 - 3.15pm Martin Brown: Stanford University, US
  Circulating monocytes promote tumour radioresistance
3.15 - 3.45pm Eric O`Neill, University of Oxford
  Epigenetic control of "stemness" and associated therapeutic resistance in tumours. - RASSF1A regulatin of the hippo stem cell pathway
3.45 - 4.15pm Tracy Robson, Queen's University of Belfast, UK
  Targeting angiogenesis and treatment resistant cancer stem cells with FKBPL and its therapeutic peptide derivatives, AD-01/ALM201

4.15pm End of meeting