Life Sciences
Cell Signalling and Therapeutics
Module code: C7118
Level 6
15 credits in autumn semester
Teaching method: Lecture
Assessment modes: Computer based exam, Coursework
On this module, you’ll explore major signalling pathways in cells, and how disruption in these pathwards can lead to uncontrolled growth and cancer.
From a research scientist perspective, you’ll learn how developing knowledge in the mechanics of these pathways can lead to the design and use of successful cancer treatments. You’ll focus on breast cancer and glioblastoma.
You’ll cover a range of these pathways, including:
- RTKs
- Ras-Raf-MEK-ERK
- PI-3-kinase, AKT and mTOR
- JAK-STAT
- integrins
- hypoxia and angiogenesis.
Module learning outcomes
- Summarise the major types of signalling pathways in the cell and explain the mechanisms underlying the activation and regulation of these pathways in breast and brain cancers.
- Appraise how multiple signalling pathways interact to produce a co-ordinated response to external stimuli within the body, promoting cell proliferation, survival and movement
- Illustrate how dysregulation in these pathways results in a loss of growth control and the development of cancer.
- Apply your knowledge of cell signalling to explain the rational design of therapeutic agents targeting these pathways in disease processes.