Selected publications

Article

Sinclair, Alison J (2017) Enhancing students’ confidence in employability skills through the practice of “recall, adapt and apply”. Higher Education Studies, 7 (3). pp. 55-63. ISSN 1925-4741

Balan, Nicolae, Osborn, Kay and Sinclair, Alison J (2016) Repression of CIITA by the Epstein-Barr virus transcription factor Zta is independent of its dimerization and DNA binding. Journal of General Virology, 97. pp. 725-732. ISSN 0022-1317

Traylen, Chris, Ramasubramanyan, Sharada, Zuo, Jianmin, Rowe, Martin, Almohammad, Rajei, Heesom, Kate, Sweet, Steve M M, Matthews, David and Sinclair, Alison J (2015) Identification of Epstein-Barr virus replication proteins in Burkitt’s lymphoma cells. Pathogens, 4 (4). pp. 739-751. ISSN 2076-0817

Ramasubramanyan, Sharada, Osborn, Kay, Al-Mohammad, Rajaei, Naranjo Perez-Fernandez, Ijiel B, Zuo, Jianmin, Balan, Nicolae, Godfrey, Anja, Patel, Harshil, Peters, Gordon, Rowe, Martin, Jenner, Richard G and Sinclair, Alison J (2015) Epstein-Barr virus transcription factor Zta acts through distal regulatory elements to directly control cellular gene expression. Nucleic Acids Research, 43 (7). pp. 3563-3577. ISSN 0305-1048

Sinclair, Alison J (2013) Epigenetic control of Epstein–Barr virus transcription – relevance to viral life cycle? Frontiers in Genetics, 4 (161). pp. 1-4. ISSN 1664-8021

Skalska, Lenka, White, Robert E, Parker, Gillian A, Turro, Ernest, Sinclair, Alison J, Pachos, Kostas and Allday, Martin J (2013) Induction of p16INK4a is the major barrier to proliferation when Epstein-Barr virus (EBV) transforms primary B cells into Lymphoblastoid cell lines. PLoS Pathogens, 9 (2). e1003187. ISSN 1553-7366

Ramasubramanyan, Sharada, Kanhere, Aditi, Osborn, Kay, Flower, Kirsty, Jenner, Richard G and Sinclair, Alison J (2012) Genome-wide analyses of Zta binding to the Epstein Barr Virus genome reveals interactions in both early and late lytic cycles and an epigenetic switch leading to an altered binding profile. Journal of Virology, 86 (23). pp. 12494-12502. ISSN 0022-538X

Ramasubramanyan, Sharada, Osborn, Kay, Flower, Kirsty and Sinclair, Alison (2012) Dynamic chromatin environment of key lytic cycle regulatory regions of the Epstein-Barr virus genome. Journal of Virology, 86 (3). pp. 1809-1819. ISSN 0022-538X

Flower, Kirsty, Thomas, David, Heather, James, Ramasubramanyan, Sharada, Jones, Susan and Sinclair, Alison J. (2011) Epigenetic Control of Viral Life-Cycle by a DNA-Methylation Dependent Transcription Factor. PLoS ONE, 6 (10). e25922. ISSN 1932-6203

Qiao, G, Duan, W, Chatwin, C, Sinclair, A and Wang, W (2010) Electrical properties of breast cancer cells from impedance measurement of cell suspensions. Journal of Physics: Conference Series, 224 (1). ISSN 1742-6588

Flower, Kirsty, Hellen, Elizabeth, Newport, Melanie J, Jones, Sue and Sinclair, Alison J (2010) Evaluation of a prediction protocol to identify potential targets of epigenetic reprogramming by the cancer associated Epstein Barr virus. PLoS ONE, 5 (2). ISSN 1932-6203

Bailey, Sarah G, Verrall, Elizabeth, Schelcher, Celine, Rhie, Alex, Doherty, Aidan J and Sinclair, Alison J (2009) Functional interaction between Epstein-Barr virus replication protein Zta and host DNA damage response protein 53BP1. Journal of Virology, 83 (21). pp. 11116-11122. ISSN 0022-538X

Broderick, Peter, Hubank, Michael and Sinclair, Alison (2009) Effects of Epstein-Barr virus on host gene expression in Burkitt's lymphoma cell lines. Chinese Journal of Cancer, 28 (8). pp. 813-821. ISSN 1944-446X

Heather, James, Flower, Kirsty, Isaac, Samine and Sinclair, Alison J (2009) The Epstein Barr virus lytic cycle activator Zta interacts with methylated ZRE in the promoter of host target gene egr1. Journal of General Virology, 90 (6). pp. 1450-1454. ISSN 0022-1317

Heather, James, Flower, Kirsty, Isaac, Samine and Sinclair, Alison (2009) The Epstein-Barr virus lytic cycle activator Zta interacts with methylated ZRE in the promoter of host target gene egr1. Journal of General Virology, 90 (6). pp. 1450-1454. ISSN 0022-1317

Karlsson, Questa H., Schelcher, Celine, Verrall, Elizabeth, Petosa, Carlo and Sinclair, Alison J. (2008) The reversal of epigenetic silencing of the EBV genome is regulated by viral bZIP protein. Biochemical Society Transactions, 36 (4). pp. 637-639. ISSN 0300-5127

Karlsson, Questa H., Schelcher, Celine, Verrall, Elizabeth, Petosa, Carlo and Sinclair, Alison J. (2008) Methylated DNA recognition during the reversal of epigenetic silencing is regulated by cysteine and cerine residues in the Epstein-Barr Virus lytic switch protein. PLoS Pathogens, 4 (3). e1000005. ISSN 1553-7366

Tambyrajah, Winston S., Bowler, Lucas D., Medina-Palazon, Cahora and Sinclair, Alison J. (2007) Cell cycle-dependent caspase-like activity that cleaves p27KIP1 is the ß1 subunit of the 20S proteasome. Archives of Biochemistry and Biophysics, 466 (2). pp. 186-193. ISSN 0003-9861

Schelcher, Celine, Al-Mehairi, Salama, Verrall, Elizabeth, Hope, Questa, Flower, Kirsty, Bromley, Beth, Woolfson, Derek N, West, Michelle J and Sinclair, Alison J (2007) Atypical bZIP Domain of Viral Transcription Factor Contributes to Stability of Dimer Formation and Transcriptional Function. Journal of Virology, 81 (13). pp. 7149-7155. ISSN 0022-538X

Sinclair, Alison J. (2006) Unexpected structure of Epstein–Barr virus lytic cycle activator Zta. Trends in Microbiology, 14 (7). pp. 289-291. ISSN 0966-842X

Schelcher, Celine, Valencia, Sarah, Delecluse, Henri-Jacques, Hicks, Matthew and Sinclair, Alison J. (2005) Mutation of a Single Amino Acide Residue in the Basic Region of the Epstein-Barr Virus (EBV) Lytic Cycle Switch Protein Zta (BZLF1) Prevents Reactivation of EBV from Latency. Journal of Virology, 79 (21). pp. 13822-13828. ISSN 0022-538X

Al Mehairi, Salama, Cerasoli, Eleonora and Sinclair, Alison J. (2005) Investigation of multimerisation region of the KSHV (HHV8) encoded protein K-bZIP: the proposed leucine zipper region encodes a multimerisation domain with an unusual structure. Journal of Virology, 79 (12). pp. 7905-7910. ISSN 0022-538X

Hayes, Michelle J., Koundouris, Anna, Gruis, Nelleke, Bergman, Wilma, Peters, Gordon G. and Sinclair, Alison J. (2004) p16INK4A-independence of Epstein–Barr virus-induced cell proliferation and virus latency. Journal of General Virology, 85 (6). pp. 1381-1386. ISSN 0022-1317

Sinclair, Alison J. (2003) bZIP proteins of human gammaherpesviruses. Journal of General Virology, 84 (8). pp. 1941-1949. ISSN 0022-1317

Hicks, Matthew R., Al-Mehairi, Salama S. and Sinclair, Alison J. (2003) The Zipper Region of Epstein-Barr Virus bZIP Transcription Factor Zta Is Necessary but Not Sufficient To Direct DNA Binding. Journal of Virology, 77 (14). pp. 8173-8177. ISSN 0022-538X

Frost, Victoria, Delikat, Sylvie, Al-Mehairi, Salama and Sinclair, Alison J. (2001) Regulation of p27KIP1 in Epstein–Barr virus-immortalized lymphoblastoid cell lines involves non-apoptotic caspase cleavage. Journal of General Virology, 82 (12). pp. 3057-3066. ISSN 0022-1317

Hicks, Matthew R., Balesaria, Sara, Medina-Palazon, Cahora, Pandya, Maya J., Woolfson, Derek N. and Sinclair, Alison J. (2001) Biophysical analysis of natural variants of the multimerization region of Epstein-Barr virus lytic-switch protein BZLF1. Journal of Virology, 75 (11). pp. 5381-5384. ISSN 0022-538X

Frost, V, Al-Mehairi, S and Sinclair, AJ (2001) Exploitation of a non-apoptotic caspase to regulate the abundance of the cdkl p27KIP1 in lymphoid cells. Oncogene, 20 (22). pp. 2737-2748. ISSN 0950-9232

Frost, V and Sinclair, AJ (2000) p27KIP1 is down-regulated by two different mechanisms in human lymphoid cells undergoing apoptosis. Oncogene, 19 (27). pp. 3115-3120. ISSN 0950-9232

Fenton, Mandy and Sinclair, Alison J. (1999) Divergent Requirements for the MAPKERK Signal Transduction Pathway during Initial Virus Infection of Quiescent Primary B Cells and Disruption of Epstein-Barr Virus Latency by Phorbol Esters. Journal of Virology, 73 (10). pp. 8913-8916. ISSN 0022-538X

Cannell, Emma J, Farrell, Paul J and Sinclair, Alison J (1998) Cell cycle arrest following exposure of EBV-immortalised B-cells to gamma irradiation correlates with inhibition of cdk2 activity. FEBS Letters, 439 (3). pp. 297-301. ISSN 0014-5793

Fenton, Mandy, Bone, Neil and Sinclair, Alison J. (1998) The efficient and rapid import of a peptide into primary B and T lymphocytes and a lymphoblastoid cell line. Journal of Immunological Methods, 212 (1). pp. 41-48. ISSN 0022-1759

Cannell, EJ, Farrell, PJ and Sinclair, AJ (1996) Epstein-Barr virus exploits the normal cell pathway to regulate Rb activity during the immortalisation of primary B-cells. Oncogene, 13 (7). pp. 1413-1421. ISSN 0950-9232

Book Section

Godfrey, Anja, Ramasubramanyan, Sharada and Sinclair, Alison J (2017) The use of chromatin precipitation coupled to DNA sequencing (ChIP-Seq) for the analysis of Zta binding to the human and EBV genome. In: Minarovits, Janos and Niller, Hans Helmut (eds.) Epstein Barr virus: methods and protocols. Methods in molecular biology, 1532 . Springer, New York, pp. 191-206. ISBN 9781493966530