School of Psychology

Influences of Early Developmental Insults on Adult Behaviour

To find out more about our research, click on a person's name and their work in this area will be highlighted.

Tamzin Ripley: consequences of addiction: impact of drugs or early life stress on adult behaviour

What are the long-term consequences of binge exposure to alcohol during adolescence on impulse control and cognition?

How do early life stressful experiences alter emotional and cognitive processes, and how might these changes effect susceptibility to future drug taking?

What are the brain mechanisms that support cognitive flexibility? And how can such knowledge improve the treatment of schizophrenia?

Homepage for Tamzin Ripley

Collaborators: Dora DukaDai StephensSarah KingHans CrombagPete CliftonAyana Gibbs
Research staff: Yolanda Pena-Oliver
Research students: Maxine Borton, Sandra Sanchez RoigeIan Sloss

See also: Alcobinge project


Sarah King: molecular and neurobiological mechanisms; gene manipulation and molecular biology

How do specific genetic polymorphisms affect cognition/addictive behaviours across the lifespan, and how do drugs interact with these processes?

How do subtypes of GABAA receptor in specific cells of the nucleus accumbens mediate the rewarding effects of drugs of abuse?

How do variations in GABAA receptor subunit genes interact with environmental events (e.g. early life stress) to influence addiction-related behaviour?

How does drug exposure (nicotine) in early development impact on corticothalamic circuits and drive changes in stress reactivity / behaviour in adulthood?

What are the molecular consequences of adolescent binge alcohol exposure that underlie changes in behaviour?

Homepage for Sarah King

Collaborators: Dora DukaDai StephensTamzin RipleyJennifer Rusted
Research Staff: Claire DixonSophie Walker
Research student: Tom MacPherson

See also:
Gaba project
Medical Research Council - Addiction
Alcobinge project
APOE, Nicotine and Alzheimer's Disease

Dai Stephens: behavioural neuroscience, behavioural genetics, alcohol, cocaine, addiction, impulsivity, GABAA receptors, incentive Learning, psychopharmacology

How does drug and alcohol abuse alter the brain, and what are the consequences for future control over drug taking?

How do differences in function of GABAergic synapses in the nucleus accumbens alter the rewarding effects of drugs of abuse? And how do genetic variations in these systems interact with environmental events to influence drug taking and seeking?        

How do genes interact with early-life stress to influence risk for addictive behaviour?

How can we make sure that what we study in animals has relevance for human addictive behaviour?

Homepage for Dai Stephens

Collaborators: Dora DukaHans CrombagTamzin RipleySarah King
Research Staff: Claire DixonSophie Walker,

See also:
Alcobinge project
Insights into Alcohol Dependence
Medical Research Council - Addiction
MRC Addiction Project and MRC Addiction Cluster Members