School of Psychology

Ageing and Dementia

To find out more about our research, click on an individual's name, and their work in this area will be highlighted.

Jenny Rusted: human psychopharmacology, cognitive ageing, cholinergic system and cognitive enhancer
What cognitive enhancement can be achieved by pharmacological interventions? Can nicotinic receptor stimulation improve cognition?

How does ApoE4 genotype affect cognition across the life span? Does nicotinic receptor stimulation affect this population differently? 

What neural signatures distinguish the cognitive indices of the APOE4 genotype?

Does good diet and exercise across the lifespan produce cognitive and neural benefits in older adulthood? Do they reduce rate of decline in older adults diagnosed with dementia?

Why and how do routine activities of daily living (ADLs) break down in older adulthood and in dementia? Can we identify effective behavioural interventions to sustain ADLs in people with dementia?

How does Prospective Memory change as we age?

How do social and psychological circumstances and resources affect the possibility of living well with dementia? Does social isolation affect rate of cognitive change?

Homepage for Jenny Rusted

Website for Jenny Rusted's Lab Group

Collaborators: Sarah King, Naji Tabet, Nick Dowell, Louise Serpell
Research staff: Simon Evans 
Research students: Sarah Balouch, Molly Berenhaus, Renata Fialho, Claire Lancaster.

 

See also: APOE, Nicotine and Alzheimer's Disease

See also: Dementia Research Group

See also: www. idealproject.org.uk

 

Chris Bird: Contextual learning and memory; neuroimaging

What links our ability to recollect past events and visualise new ones?

What are the common brain systems necessary for doing this?

How do we update and change memories over time?

How do we remember locations in the world and the events that happened there?

Homepage for Chris Bird

Collaborators: Jenny Rusted,Dennis Chan
Research students: Sam Berens 

Sarah King: molecular and neurobiological mechanisms; gene manipulation and molecular biology

How do specific genetic polymorphisms affect cognition/addictive behaviours across the lifespan, and how do drugs interact with these processes?

How do subtypes of GABAA receptor in specific cells of the nucleus accumbens mediate the rewarding effects of drugs of abuse?

How do variations in GABAA receptor subunit genes interact with environmental events (e.g. early life stress) to influence addiction-related behaviour?

How does drug exposure (nicotine) in early development impact on corticothalamic circuits and drive changes in stress reactivity / behaviour in adulthood?

What are the molecular consequences of adolescent binge alcohol exposure that underlie changes in behaviour?

Homepage for Sarah King

Collaborators: Jennifer Rusted, John Atack
See also: APOE, Nicotine and Alzheimer's Disease