Sussex Neuroscience

Dr Onyx Adesakin

Onyx AdesakinUnderstanding Tau biology in Alzheimer’s disease

Work in the Adesakin Lab is aimed at understanding the molecular mechanisms that underline Alzheimer’s disease using our favourite model, the fruit fly, Drosophila. Although we have gained significant advances, and identified key molecules that play a role in Alzheimer’s disease (AD), there still remains no cure for the disease.


Project Summary
Our goal is to uncover potential pathways/proteins involved in AD progression in order to identify potential therapeutic targets. Alzheimer’s disease is characterised by the mis-folding of two proteins, extracellular amyloid beta plaques and intracellular neurofibrillary hyperphosphorylated Tau (NFT) tangles. In this project, we will investigate a role of Tau in various cellular and subcellular compartments to gain a better understanding of the role it plays in AD pathogenesis, because the precise mechanism of Tau-induced neurotoxicity remains a critical question in AD. For our studies, we will utilize Drosophila models of Alzheimer’s disease. Drosophila has the benefits of powerful genetics, a relatively short lifespan, and though a fly brain is very different to humans, it has a relatively complex nervous system. This work is expected to inform us of the mechanism/s of Tau induced neurotoxicity by making use of several molecular tools and several behavioural readouts to assess neuronal function/neurodegeneration in fly AD models.

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