Sussex Neuroscience

Dr Charlotte Rae

CharlotteCognitive neuroscience of adaptive behavioural control, and alterations in neuropsychiatric conditions & under lifestyle challenges

Research in the Adaptive Behavioural Control lab investigates the neural processes supporting voluntary action and inhibitory control. We use a combination of cognitive neuroscience techniques, including fMRI, diffusion MRI, psychophysiology, and computational modelling, with tasks of executive function. We use these to study how signals from the body cue our actions (and our inactions), how these processes are altered in neuropsychiatric conditions (in particular, Tourette syndrome), and the impact of lifestyle challenges, such as not getting enough sleep.

Projects in the lab will involve human neuroimaging studies, applying MRI connectivity analysis techniques to delineate neural networks supporting adaptive behavioural control, in healthy participants and in applied groups, such as sleep restricted individuals. Projects may also include physiological measurements (such as ECG or sleep monitoring with actigraphy), and computational modelling (such as drift diffusion models of reaction time).

Students will acquire skills in programming (e.g. matlab), neuroanatomy, MRI data acquisition and analysis, and psychophysiological techniques.

Collaborators within Sussex Neuroscience
Dr Dan Campbell-Meiklejohn
Prof Hugo Critchley
Prof Dora Duka
Prof Sarah Garfinkel

Selected publications

(For a full list of publications and more details about the lab, see the Adaptive Behavioural Control homepage .)

Rae CL, Critchley HD, Seth AK. (2019). A Bayesian account of the sensory-motor interactions underlying symptoms of Tourette Syndrome. Frontiers in Psychiatry, 10, 29. DOI: 10.3389/fpsyt.2019.00029, PMID: 30890965

Rae CL, Polyanska L, Gould van Praag CD, Parkinson J, Bouyagoub S, Nagai Y, Seth AK, Harrison N, Garfinkel SN, Critchley HD. (2018). Face perception enhances insula and motor network reactivity in Tourette Syndrome. Brain, 141, 3249-3261. DOI: 10.1093/brain/awy254, PMID: 30346484

Rae CL, Botan VE, Gould van Praag CD, Herman AM, Nyyssonen JAK, Watson DR, Duka T, Garfinkel SN, Critchley HD. (2018). Response inhibition on the stop signal task improves during cardiac contraction. Scientific Reports, 8, 9136. DOI: 10.1038/s41598-018-27513-y, PMID: 29904123

Rae CL, Hughes LE, Anderson MC, Rowe JB. (2015). The prefrontal cortex achieves inhibitory control by facilitating subcortical motor pathway connectivity. Journal of Neuroscience, 35, 786-794. DOI: 10.1523/JNEUROSCI.3093-13.2015, PMID: 25589771