Dr Michael Titheradge

Biography

Background: 

1973             1st Class B.Sc. Hons, Medical Biochemistry, University of Birmingham

1976             Ph.D Biochemistry, University of Birmingham

                    The Regulation of Mitochondrial Pyruvate Transport

1976-79        Postdoctoral Fellow, Dept. of Pharmacology, University of Virginia, U.S.A.

1979-1994     Lecturer in Biochemistry,  Department of Biochemistry, University of Sussex

1994-2001     Senior Lecturer in Biochemistry, Department of Biochemistry, University of Sussex

2001-2005     Head of Biochemistry, Department of Biochemistry, University of Sussex

2007-2009     Deputy Head of Biochemistry, Department of Biochemistry,University of Sussex

2009-2010     Director of Student Support, School of Life Sciences, University of Sussex

2010-            Phase 1 Lead, BM BS degree, Brightonand Sussex Medical School

                     Senior Lecturer in Biochemistry, Department of Biochemistry, University of Sussex

Awards:      2009    University of Sussex Teaching Award

                   2010    BSMS Top Teachers Award            

Role

Programme Convenor BSc Biomedical Science (Life Sciences)

Course Organiser of:

• Cell Regulation and Cancer
• Cell Signalling and its Application in Disease and Therapeutics
• Clinical Aspects of Biochemistry
• Clinical Chemistry
• Endocrinology and Disease
• Haematology
• Introduction to Pharmacology
• Principles of Drug Action

Committees:

• Programme Convenors Committee
• Life Sciences Teaching and Learning Committee

Phase 1 (Yrs 1 & 2)Lead BM BS degree (Brighton and Sussex Medical School)

Discipline Leader for Biochemistry

Module lead for 104 Nutrition, Metabolism and Excretion

Committees:

• BSMS Academic Board
• BSMS Curriculum Management Board
• BSMS Curriculum Development and Strategy Group
• BSMS Professional Conduct Committee
• BSMS Admissions Board
• BSMS Quality Assurance Sub-Committee
• BSMS Student Affairs Committee
• BSMS Phase 1 Exam Board
• BSMS Phase 2 exam Board
• BSMS Phase 3 Exam Board
• BSMS Exam Boards for Modules 101, 102, 103, 104, 201, 202, 203, 204
• Chair of BSMS Module 104 Review Board
• BSMS Review Boards for Modules 101, 102, 103, 104, 201, 202, 203, 204

Control of carbohydrate metabolism in response to bacterial endotoxins and pro-inflammatory cytokines and the role of dimethyl arginine derivatives in vascular disease.
A major characteristic of overwhelming sepsis in animals is a fall in blood glucose arising from an inhibition of gluconeogenesis and decreased capacity of the liver to store and mobilize glycogen. It is evident that the presence of bacterial endotoxins in the bloodstream cause the release of proinflammatory cytokines (IL-1b, IL-6, TNF-a and IFN-g) and the overproduction of nitric oxide and this is a crucial element of the pathophysiology observed at the onset of septic shock We have provided evidence that overproduction of nitric oxide can partially account for the inability of the liver to carry out gluconeogenesis and also the liver damage observed in response to cytokines, but not the inability to make and release glycogen during periods of falling blood glucose. Our research is directed at understanding the mechanisms by which glycogen metabolism in both the liver and muscle is controlled by proinflammatory cytokines and the mechanisms by which these may interfere with signaling in response to insulin during sepsis. In addition to being a potentially toxic agent, nitric oxide production is essential for maintaining vascular tone causing relaxation. Related research is investigating the potential role of asymmetric dimethyl arginine (a natural inhibitor of nitric oxide production produced in our bodies) to inhibit nitric oxide production rendering the vasculature more susceptible to damage and the development of vascular disease.

Life Sciences

• Biological Chemistry
• Cell Regulation and Cancer

• Cell Signaling and its Applications in disease and Therapeutics

• Clinical Aspects of Biochemistry
• Clinical Chemistry

• Critical Thinking in Biochemistry
• Cell and Molecular Biology
• Endocrinology and Disease
• Essential Skills for Biomedical Science
• Introduction to Structural Pharmacology
• Principles of Drug Action
• Research Methods in Biochemistry

Brighton and Sussex Medical School

• BSMS Moldule 102 Foundations of Health and Disease
• BSMS Module 104 Nutrition Metabolism and Excretion

Addisu, S, El-Metwally, T H, Davey, G, Worku, Y and Titheradge, Michael (2010) The role of transforming growth factor-ß1 and oxidative stress in podoconiosis pathogenesis. British Journal of Dermatology, 162 (5). pp. 998-1003. ISSN 0007-0963

Weaving, Gary, Rocks, Bernard F, Bailey, Michael P and Titheradge, Michael A (2009) Liquid chromatography: Is it essential for the determination of arginine and methylated arginines by tandem mass spectrometry? Journal of Chromatography B, 877 (27). pp. 3267-3269. ISSN 1570-0232

Weaving, Gary, Rocks, Bernard F, Bailey, Michael P and Titheradge, Michael A (2008) Arginine and methylated arginines in human plasma and urine measured by tandem mass spectrometry without the need for chromatography or sample derivatisation. Journal of Chromatography B, 874 (1-2). pp. 27-32. ISSN 1570-0232

Wallington, Jennifer, Ning, Jian and Titheradge, Michael Alan (2008) The control of hepatic glycogen metabolism in an in vitro model of sepsis. Molecular and Cellular Biochemistry, 308 (1-2). pp. 183-192. ISSN 0300-8177

Weaving, G, Rocks, B F, Iversen, S A and Titheradge, M A (2006) Simultaneous quantification of homocysteine, cysteine and methionine in plasma and urine by liquid chromatography-tandem mass spectrometry. Annals of Clinical Biochemistry, 43 (6). pp. 474-480. ISSN 0004-5632

Titheradge, Michael (1999) Nitric oxide in septic shock. BBA - Bioenergetics, 1411 (2-3). pp. 437-455. ISSN 0005-2728

Titheradge, Michael (1998) Nitric oxide protocols. Methods in Molecular Biology, 100 . Humana Press, New Jersey, pp. 83-91. ISBN 9780896035379

Smith, F S, Ceppi, E D and Titheradge, M A (1997) Inhibition of cytokine-induced inducible nitric oxide synthase expression by glucagon and cAMP in cultured hepatocytes. Biochemical Journal, 326 (1). pp. 187-192. ISSN 02646021