Article

Agnarelli, Alessandro, Mitchell, Simon, Caalim, Gillian, Wood, C David, Milton-Harris, Leanne, Chevassut, Timothy, West, Michelle J and Mancini, Erika J (2022) Dissecting the impact of bromodomain inhibitors on the IRF4-MYC oncogenic axis in multiple myeloma. Hematological Oncology, 40 (3). pp. 417-429. ISSN 0278-0232

Wagstaff, Megan, Tsaponina, Olga, Caalim, Gilian, Greenfield, Hayley, Milton-Harris, Leanne, Mancini, Erika J, Blair, Allison, Heesom, Kate J, Tonks, Alex, Darley, Richard L, Roberts, Stefan G and Morgan, Rhys G (2022) Crosstalk between β-catenin and WT1 signalling activity in acute myeloid leukemia. Haematologica. ISSN 0390-6078

Agnarelli, Alessandro, Omari, Kamel El, Duman, Ramona, Wagner, Armin and Mancini, Erika J (2021) Phosphorus and sulfur SAD phasing of the nucleic acid-bound DNA-binding domain of interferon regulatory factor 4. Acta Crystallographica Section F: Structural Biology Communications, 77 (7). pp. 202-207. ISSN 2053-230X

Piepoli, Sofia, Alt, Aaron Oliver, Atilgan, Canan, Mancini, Erika Jazmin and Erman, Batu (2020) Structural analysis of the PATZ1 BTB domain homodimer. Acta Crystallographica Section D: Structural Biology, 76. pp. 581-593. ISSN 2059-7983

Milton-Harris, Leanne, Jeeves, Mark, Walker, Sarah A, Ward, Simon E and Mancini, Erika J (2020) Small molecule inhibits T-cell acute lymphoblastic leukaemia oncogenic interaction through conformational modulation of LMO2. Oncotarget, 11. pp. 1737-1748. ISSN 1949-2553

Karia, Dimple, Gilbert, Robert C G, Biasutto, Antonio J, Porcher, Catherine and Mancini, Erika J (2020) The histone H3K4 demethylase JARID1A directly interacts with haematopoietic transcription factor GATA1 in erythroid cells through its second PHD domain. Royal Society Open Science, 7 (1). ISSN 2054-5703

Agnarelli, Alessandro, Chevassut, Timothy and Mancini, Erika (2018) IRF4 in multiple myeloma—biology, disease and therapeutic target. Leukemia Research, 72. pp. 52-58. ISSN 0145-2126

Almohammed, Rajaei, Osborn, Kay, Ramasubramanyan, Sharada, Naranjo Perez-Fernandez, Ijiel Barak, Godfrey, Anja, Mancini, Erika J and Sinclair, Alison J (2018) Mechanism of activation of the BNLF2a immune evasion gene of Epstein-Barr virus by Zta. Journal of General Virology, 99. pp. 805-817. ISSN 0022-1317

Wilson, Rosemary H C, Biasutto, Antonio J, Wang, Lihao, Fischer, Roman, Baple, Emma L, Crosby, Andrew H, Mancini, Erika J and Green, Catherine M (2016) PCNA dependent cellular activities tolerate dramatic perturbations in PCNA client interactions. DNA Repair, 50. pp. 22-35. ISSN 1568-7856

Walport, Louise J, Morra, Rosa, Mancini, Erika J and Redfield, Christina (2015) 1H, 13C, and 15N resonance assignments for the tandem PHD finger motifs of human CHD4. Biomolecular NMR Assignments, 9 (2). pp. 239-242. ISSN 1874-2718

Mancini, Erika J and West, Michelle J (2015) How to be a pioneer: a one-sided view. Trends in Biochemical Sciences, 40 (10). pp. 547-548. ISSN 0968-0004

Vivante, Asaf, Kleppa, Marc-Jens, Schulz, Julian, Kohl, Stefan, Sharma, Amita, Chen, Jing, Shril, Shirlee, Hwang, Daw-Yang, Weiss, Anna-Carina, Kaminski, Michael M, Shukrun, Rachel, Kemper, Markus J, Lehnhardt, Anja, Beetz, Rolf, Sanna-Cherchi, Simone, Verbitsky, Miguel, Gharavi, Ali G, Stuart, Helen M, Feather, Sally A, Goodship, Judith A, Goodship, Timothy H J, Woolf, Adrian S, Westra, Sjirk J, Doody, Daniel P, Bauer, Stuart B, Lee, Richard S, Adam, Rosalyn M, Lu, Weining, Reutter, Heiko M., Kehinde, Elijah O, Mancini, Erika J, Lifton, Richard P, Tasic, Velibor, Lienkamp, Soeren S, Jüppner, Harald, Kispert, Andreas and Hildebrandt, Friedhelm (2015) Mutations in TBX18 cause dominant urinary tract malformations via transcriptional dysregulation of ureter development. American Journal of Human Genetics, 97 (2). pp. 291-301. ISSN 0002-9297

Sewell, H, Tanaka, T, Omari, K E, Mancini, E J, Cruz, A, Fernandez-Fuentes, N, Chambers, J and Rabbitts, T H (2015) Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex. Scientific Reports, 4 (1). a3643. ISSN 2045-2322

El Omari, Kamel, Sutton, Geoff, Ravantti, Janne J, Zhang, Hanwen, Walter, Thomas S, Grimes, Jonathan M, Bamford, Dennis H, Stuart, David I and Mancini, Erika J (2013) Plate tectonics of virus shell assembly and reorganization in phage φ8, a distant relative of mammalian reoviruses. Structure, 21 (8). pp. 1384-1395. ISSN 1878-4186

El Omari, Kamel, Hoosdally, Sarah J, Tuladhar, Kapil, Karia, Dimple, Hall-Ponselé, Elisa, Platonova, Olga, Vyas, Paresh, Patient, Roger, Porcher, Catherine and Mancini, Erika J (2013) Structural basis for LMO2-driven recruitment of the SCL: E47bHLH heterodimer to hematopoietic-specific transcriptional targets. Cell Reports, 4 (1). pp. 135-147. ISSN 2211-1247

El Omari, Kamel, Meier, Christoph, Kainov, Denis, Sutton, Geoff, Grimes, Jonathan M, Poranen, Minna M, Bamford, Dennis H, Tuma, Roman, Stuart, David I and Mancini, Erika J (2013) Tracking in atomic detail the functional specializations in viral RecA helicases that occur during evolution. Nucleic Acids Research, 41 (20). pp. 9396-9410. ISSN 1362-4962

Morra, Rosa, Lee, Benjamin M, Shaw, Heather, Tuma, Roman and Mancini, Erika J (2012) Concerted action of the PHD, chromo and motor domains regulates the human chromatin remodelling ATPase CHD4. FEBS Letters, 586 (16). pp. 2513-2521. ISSN 0014-5793

El Omari, Kamel, De Mesmaeker, Julie, Karia, Dimple, Ginn, Helen, Bhattacharya, Shoumo and Mancini, Erika J (2012) Structure of the DNA-bound T-box domain of human TBX1, a transcription factor associated with the DiGeorge syndrome. Proteins, 80 (2). pp. 655-660. ISSN 0887-3585

Mancini, Erika J and Tuma, Roman (2012) Mechanism of RNA packaging motor. Advances in Experimental Medicine and Biology, 726. pp. 609-629. ISSN 0065-2598

El Omari, Kamel, Hoosdally, Sarah J, Tuladhar, Kapil, Karia, Dimple, Vyas, Paresh, Patient, Roger, Porcher, Catherine and Mancini, Erika J (2011) Structure of the leukemia oncogene LMO2: implications for the assembly of a hematopoietic transcription factor complex. Blood, 117 (7). pp. 2146-2156. ISSN 1528-0020

El Omari, Kamel, Porcher, Catherine and Mancini, Erika J (2010) Purification, crystallization and preliminary X-ray analysis of a fusion of the LIM domains of LMO2 and the LID domain of Ldb1. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66 (11). pp. 1466-1469. ISSN 1744-3091

Bollati, Michela, Alvarez, Karin, Assenberg, René, Baronti, Cécile, Canard, Bruno, Cook, Shelley, Coutard, Bruno, Decroly, Etienne, de Lamballerie, Xavier, Gould, Ernest A, Grard, Gilda, Grimes, Jonathan M, Hilgenfeld, Rolf, Jansson, Anna M, Malet, Hélène, Mancini, Erika J, Mastrangelo, Eloise, Mattevi, Andrea, Milani, Mario, Moureau, Grégory, Neyts, Johan, Owens, Raymond J, Ren, Jingshan, Selisko, Barbara, Speroni, Silvia, Steuber, Holger, Stuart, David I, Unge, Torsten and Bolognesi, Martino (2010) Structure and functionality in flavivirus NS-proteins: perspectives for drug design. Antiviral Research, 87 (2). pp. 125-148. ISSN 0166-3542

Assenberg, René, Mastrangelo, Eloise, Walter, Thomas S, Verma, Anil, Milani, Mario, Owens, Raymond J, Stuart, David I, Grimes, Jonathan M and Mancini, Erika J (2009) Crystal structure of a novel conformational state of the flavivirus NS3 protein: Implications for polyprotein processing and viral replication. Journal of Virology, 83 (24). pp. 12895-12906. ISSN 0022-538X

Meier, Christoph, Carter, Lester G, Sainsbury, Sarah, Mancini, Erika J, Owens, Raymond J, Stuart, David I and Esnouf, Robert M (2008) The crystal structure of UMP Kinase from Bacillus anthracis (BA1797) reveals an allosteric nucleotide-binding site. Journal of Molecular Biology, 381 (5). pp. 1098-1105. ISSN 0022-2836

Telenius, Jelena, Wallin, Anders E, Straka, Michal, Zhang, Hongbo, Mancini, Erika J and Tuma, Roman (2008) RNA packaging motor: From structure to quantum mechanical modelling and sequential-stochastic mechanism. Computational and Mathematical Methods in Medicine, 9 (3-4). pp. 351-369. ISSN 1748-670X

Martin, Morag C, Allan, Lindsey A, Mancini, Erika J and Clarke, Paul R (2008) The docking interaction of caspase-9 with ERK2 provides a mechanism for the selective inhibitory phosphorylation of caspase-9 at threonine 125. Journal of Biological Chemistry, 283 (7). pp. 3854-3865. ISSN 0021-9258

Kainov, Denis E, Mancini, Erika J, Telenius, Jelena, Lísal, Jiří, Grimes, Jonathan M, Bamford, Dennis H, Stuart, David I and Tuma, Roman (2008) Structural basis of mechanochemical coupling in a hexameric molecular motor. Journal of Biological Chemistry, 283 (6). pp. 3607-3617. ISSN 0021-9258

Walter, T S, Mancini, E J, Kadlec, J, Graham, S C, Assenberg, R, Ren, J, Sainsbury, S, Owens, R J, Stuart, D I, Grimes, J M and Harlos, K (2008) Semi-automated microseeding of nanolitre crystallization experiments. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 64 (1). pp. 14-18. ISSN 1744-3091

Mancini, Erika J, Assenberg, Rene, Verma, Anil, Walter, Thomas S, Tuma, Roman, Grimes, Jonathan M, Owens, Raymond J and Stuart, David I (2007) Structure of the Murray Valley encephalitis virus RNA helicase at 1.9 Å resolution. Protein Science, 16 (10). pp. 2294-2300. ISSN 0961-8368

Kainov, D E, Tuma, R and Mancini, E J (2006) Hexameric molecular motors: P4 packaging ATPase unravels the mechanism. Cellular and Molecular Life Sciences, 63 (10). pp. 1095-1105. ISSN 1420-682X

Meier, C, Mancini, E J, Bamford, D H, Walsh, M A, Stuart, D I and Grimes, J M (2005) Overcoming the false-minima problem in direct methods: Structure determination of the packaging enzyme P4 from bacteriophage φ13. Acta Crystallographica Section D: Biological Crystallography, 61 (9). pp. 1238-1244. ISSN 0907-4449

Mancini, Erika J, Kainov, Denis E, Grimes, Jonathan M, Tuma, Roman, Bamford, Dennis H and Stuart, David I (2004) Atomic snapshots of an RNA packaging motor reveal conformational changes linking ATP hydrolysis to RNA translocation. Cell, 118 (6). pp. 743-755. ISSN 0092-8674

Mancini, E J, Kainov, D E, Wei, H, Gottlieb, P, Tuma, R, Bamford, D H, Stuart, D I and Grimes, J M (2004) Production, crystallization and preliminary X-ray crystallographic studies of the bacteriophage φ12 packaging motor. Acta Crystallographica Section D: Biological Crystallography, 60 (3). pp. 588-590. ISSN 0907-4449

Mancini, E J, Grimes, J M, Malby, R, Sutton, G C, Kainov, D E, Juuti, J T, Makeyev, E V, Tuma, R, Bamford, D H and Stuart, D I (2003) Order and disorder in crystals of hexameric NTPases from dsRNA bacteriophages. Acta Crystallographica Section D: Biological Crystallography, 59 (12). pp. 2337-2341. ISSN 0907-4449

Brown, J, Walter, T S, Carter, L, Abrescia, N G A, Aricescu, A R, Batuwangala, T D, Bird, L E, Brown, N, Chamberlain, P P, Davis, S J, Dubinina, E, Endicott, J, Fennelly, J A, Gilbert, R J C, Harkiolaki, M, Hon, W-C, Kimberley, F, Love, C A, Mancini, E J, Manso-Sancho, R, Nichols, C E, Robinson, R A, Sutton, G C, Schueller, N, Sleeman, M C, Stewart-Jones, G B, Vuong, M, Welburn, J, Zhang, Z, Stammers, D K, Owens, R J, Jones, E Y, Harlos, K and Stuart, D I (2003) A procedure for setting up high-throughput nanolitre crystallization experiments. II. Crystallization results. Journal of Applied Crystallography, 36 (2). pp. 315-318. ISSN 0021-8898

Fuller, Stephen, Gowen, Brent, Brady, Sinead, Watson, Barbara, Briggs, John, Mancini, Erika and Matadeen, Rishi (2002) Cryo-electron microscopy of large complexes: a cold look at fusion. Microscopy and Microanalysis, 8 (S02). pp. 1016-1017. ISSN 1431-9276

Mancini, E J and Fuller, S D (2000) Supplanting crystallography or supplementing microscopy? A combined approach to the study of an enveloped virus. Acta Crystallographica Section D: Biological Crystallography, 56 (10). pp. 1278-1287. ISSN 0907-4449

Mancini, Erika J, Clarke, Mairi, Gowen, Brent E, Rutten, Twan and Fuller, Stephen D (2000) Cryo-electron microscopy reveals the functional organization of an enveloped virus, Semliki Forest virus. Molecular Cell, 5 (2). pp. 255-266. ISSN 1097-2765

Ferlenghi, Ilaria, Gowen, Brent, de Haas, Felix, Mancini, Erika J, Garoff, Henrik, Sjöberg, Mathilda and Fuller, Stephen D (1998) The first step: activation of the semliki forest virus spike protein precursor causes a localized conformational change in the trimeric spike. Journal of Molecular Biology, 283 (1). pp. 71-81. ISSN 0022-2836

Mancini, Erika J, de Haas, Felix and Fuller, Stephen D (1997) High-resolution icosahedral reconstruction: fulfilling the promise of cryo-electron microscopy. Structure, 5 (6). pp. 741-750. ISSN 0969-2126