Mr Michael Paradowski
|Post:||Research Fellow (Chemistry)|
|Location:||Chichester 3 3r508|
|International:||+44 1273 873881|
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Michael has 14 years of industrial experience in the field of Medicinal Chemistry. After obtaining his chemistry degree from Ecole Nationale Superieure d'Ingenieurs (Caen, France), Michael joined Pfizer (Sandwich, UK) where he worked as a Project Synthetic Leader on a number of antiviral, obesity and allergy & respiratory medicinal programmes , including the CCR5 antagonist Maraviroc®,Phase II long acting β2 adrenoreceptor agonist PF-610,355 and Phase I histamine H4 antagonist PF-3893787. He has lmany years of experience in leading large CRO groups from Asia and Europe.
Paradowski, Michael (2011) A flexible synthesis of C-6 and N-1 analogues of a 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-one core. Tetrahedron Letters, 52 (44). pp. 5728-5732. ISSN 00404039
Paradowski, Michael (2011) Challenges of drug discovery in novel target space. The Discovery and Evaluation of PF-3893787: A Novel Histamine H4 Receptor Antagonist. Bioorganic & Medicinal Chemistry Letters, 21. pp. 6596-6602. ISSN 0960894X
Egan, Ben A, Paradowski, Michael, Thomas, Lynne H and Marquez, Rodolfo (2011) Synthesis of the C1-C16 fragment of the ajudazols. Tetrahedron, 67 (50). pp. 9700-9707. ISSN 0040-4020
Paradowski, Michael (2011) Development of a Practical Synthesis of Toll-like Receptor Agonist PF-4171455: 4-Amino-1-benzyl-6-trifluoromethyl-1,3-dihydroimidazo [4,5-c] pyridin-2-one. Organic Process Research and Development, 45 (4). pp. 788-796. ISSN 10836160
Paradowski, Michael (2011) Regiocontrolled Rearrangement of Isobenzofurans. Organic Letters, 13 (8). pp. 2086-2089. ISSN 15237060
Paradowski, Michael (2011) Synthesis of a novel octahydro pyrrolo[3,4-c] pyrrole cyclic amidine via 1,3-dipolar cycloaddition of azomethine ylides. Synlett (11). pp. 1543-1546. ISSN 09365214
Paradowski, Michael (2011) The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection. MedChemComm, 2 (3). pp. 185-189. ISSN 20402503
Paradowski, Michael (2010) Novel isobenzofuran oxidative rearrangements: Total synthesis of Ajudazol A. In: 239th ACS National Meeting, San Francisco, CA, United States.