MSc, 1 year full time
Subject overview
We are a leading centre of research and were ranked 8th in the UK for ‘Pre-clinical and Human Biological Sciences’ research in the 2008 Research Assessment Exercise (RAE). 85 per cent of our research was rated as internationally recognised or higher, and over half rated as internationally excellent or higher.
Sussex was ranked in the top 25 in the UK for biological sciences in The Times Good University Guide 2013 and in the top 30 in the UK in The Complete University Guide 2014.
We are proud of our distinguished faculty, past and present: the most recent of the University’s 15 Fellows of the Royal Society is geneticist Alan Lehmann.
We offer formal taught research and study skills training to all postgraduates.
Our collaborative links with the Genome Damage and Stability Centre and the Brighton and Sussex Medical School offer exciting opportunities for our research and Masters students to experience cutting-edge research projects across a broad range of interdisciplinary areas.
We have excellent facilities for protein molecular graphics and bioinformatics, atomic force microscopy, x-ray crystallography, FACS analysis, mammalian cell culture, confocal, 2-photon and time-lapse video microscopy, cryo- and scanning electron-microscopy, mass spectroscopy and NMR.
Programme outline
Most biological disciplines now rely on analyses at the molecular level, and the use of molecular biology to manipulate genes and proteins.
This MSc provides detailed training in current approaches to molecular biology and functional genomics. A large part of the degree is devoted to an individual research project undertaken in a research-active lab.
We continue to develop and update our modules for 2013 entry to ensure you have the best student experience. In addition to the course structure below, you may find it helpful to refer to the 2012 modules tab.
You take four core MSc modules, together with a choice of several final-year undergraduate modules.
Autumn and spring terms: Advanced Methods in Molecular Research • Practicals in Cell, Molecular and Developmental Biology • Skills for Research Bioscientists • Topics in Genetic Manipulation and Molecular Cell Biology. Additionally you choose one or two modules from a list of options including Genome Stability, Genetic Diseases and Cancer • Genomics • Molecular Genetics • Post-Transcriptional Control of Gene Expression • Protein Form and Function • Regulating the Transcriptome. You also start your research project.
Summer term: you continue your research project.
Assessment
You are assessed by examinations, a thesis dissertation and oral presentation of your work.
Current modules
Please note that these are the core modules and options (subject to availability) for students starting in the academic year 2012.
Core modules
- Advanced Methods in Molecular Research
- Life Sciences Master of Science Research Project
- Life Sciences Masters Research Proposal
- Practical Techniques in Cell, Molecular and Developmental Biology
- Skills for Research Bioscientists
- Topics in Genetic Manipulation and Molecular Cell Biology
Options
Advanced Methods in Molecular Research
15 credits
Autumn teaching, year 1
This module is designed to teach you about the techniques available to modern molecular genetics and molecular cell biology researchers. For each technique you will be required to analyse data and comment on the applicability of that technique to the biological problem being investigated.
Genome Stability, Genetic Diseases and Cancer
15 credits
Spring teaching, year 1
The design of new therapies for cancer depends on first understanding the molecular events that cause the disease. Genomic DNA is damaged spontaneously by chemical carcinogens and by radiation. If unrepaired, this damage leads to mutations, cancer and other developmental disorders. All cells have evolved a sophisticated array of repair and response mechanisms to deal with DNA damage. The aim of this module is to understand the molecular mechanisms that control DNA repair and to appreciate how defects in genes involved in these repair processes are associated with different, in many cases cancer-prone, genetic disorders. Throughout the module, emphasis will be placed on both the review and critical evaluation of recently published experimental evidence; advances in this area rely on a combination of biochemical analysis, genetic approaches and bioinformatics. Lectures on this module will be complemented by discussion groups.
Genomics and Bioinformatics
15 credits
Spring teaching, year 1
This module will introduce the common types of genomic and proteomic data available in biological databases; including DNA and protein sequences, motifs, gene structure, protein interactions and expression profiles. The aims and methods of DNA and protein sequence analysis will be covered, including analysis of homology, identification of motifs and domains, pair-wise and multiple alignments and prediction of gene structure.
The practical sessions will include the analysis of DNA and protein sequence data from biological databases. In these sessions you will learn how to integrate data to find the functional links between disease related genes and proteins.
Introduction to Genes and Biochemistry
15 credits
Autumn teaching, year 1
This module will provide background knowledge of five basic units of biochemistry and the relationship between genes and proteins within the cell. Unit 1 deals with the molecules of life, DNA, RNA, nucleotides and the central dogma of molecular biology. Unit 2 covers the decoding of the genetic code through the processes of transcription and translation. Unit 3 deals with proteins, their structure properties and amino acid building blocks. Unit 4 deals with enzymes and simple enzyme catalysed reactions. Unit 5 covers metabolism and uses glycolysis and Krebs cycle as examples of typical pathways bioenergentics is briefly introduced.
Life Sciences Master of Science Research Project
60 credits
Spring teaching, year 1
This module gives you the opportunity to design and perform an original piece of research in consultation with a research supervisor. You perform experiments that set out to answer questions posed at the beginning of the experimental work.
Life Sciences Masters Research Proposal
15 credits
Spring teaching, year 1
On this module you will use primary literature to study the background to a biological problem in the fields of genetic manipulation and/or cell biology. You will then devise an experimental strategy by which this problem can be studied, giving details of techniques and resources that will be used to address the problem.
Molecular Genetics
15 credits
Autumn teaching, year 1
The module will cover the application of molecular genetics to the study of processes in model systems and higher eukaryotes. Particular topics will include cell cycle and checkpoint control, recombination and mating type switching in lower eukaryotes, gene mapping and cloning disease genes in higher eukaryotes, and the production of transgenic animals.
Post Transcriptional Control of Gene Expression
15 credits
Spring teaching, year 1
This module explores in detail the molecular mechanisms controlling RNA export, translation and decay in eukaryotes. It focuses on how such processes are carried out and regulated - by hormones and growth factors, miRNAs, viral infection, ischaemia, hypoxia and stress - and what goes wrong in the diseased state.
Practical Techniques in Cell, Molecular and Developmental Biology
30 credits
Autumn teaching, year 1
This module exposes you to a number of techniques used in basic molecular research. Particularly suitable for those with limited laboratory experience, it prepares you for undertaking a research project. The module consists of three basic elements: laboratory skills, bioinformatics skills, and theoretical understanding.
Protein Form and Function
15 credits
Spring teaching, year 1
Protein Form and Function provides a sense of how protein structures are related to each other and of how these structures relate to protein function. On this module you will be equipped with the necessary knowledge and skills to learn about and appreciate this class of molecule. This module covers aspects of protein structure in detail and introduces computational and experimental techniques that are essential for studying proteins, and provides the basis for the in depth discussion of more topical issues such as protein engineering and design, protein folding, chaperones and protein folding diseases.
Regulating the Transcriptome
15 credits
Autumn teaching, year 1
This module takes an in- depth look at the molecular mechanisms controlling RNA expression in prokaryotes and eukaryotes, focussing largely on gene transcription but also examining RNA processing events. The mechanism of action of RNA polymerase, transcription factors and RNA processing factors will also be examined in detail.
Skills for Research Bioscientists
15 credits
Autumn teaching, year 1
This module will prepare you for some of the challenges that you will meet as a professional research bioscientist. These will include scientific writing and other presentational skills, effective use of various software packages, training in the use of radioactivity and specialised equipment, and the preparation of CVs and grant applications.
Topics in Genetic Manipulation and Molecular Cell Biology
15 credits
Spring teaching, year 1
This module considers recent advances in the fields of genetic manipulation and molecular cell biology. Weekly seminars will cover topics such as genetic engineering, electron microscopy, oncogenes, protein engineering, genomics and proteomics.
By the end of the module you should be able to describe and explain techniques used to investigate a variety of cellular and molecular processes, and to critically assess and interpret experimental data generated using these techniques. You will also learn to extract and utilise relevant information from scientific literature.
Entry requirements
UK entrance requirements
A first- or second-class undergraduate honours degree in a relevant science, computing or mathematics subject.
Overseas entrance requirements
Please refer to column B on the Overseas qualifications.
If you have any questions about your qualifications after consulting our overseas
qualifications table, contact the University.
E pg.enquiries@sussex.ac.uk
Visas and immigration
Find out more about Visas and immigration.
English language requirements
IELTS 6.5, with not less than 6.5 in Writing and 6.0 in the other sections. Internet TOEFL with 88 overall, with at least 20 in Listening, 20 in Reading, 22 in Speaking and 24 in Writing.
For more information, refer to English language requirements.
For more information about the admissions process at Sussex
For pre-application enquiries:
Student Recruitment Services
T +44 (0)1273 876787
E pg.enquiries@sussex.ac.uk
For post-application enquiries:
Postgraduate Admissions,
University of Sussex,
Sussex House, Falmer,
Brighton BN1 9RH, UK
T +44 (0)1273 877773
F +44 (0)1273 678545
E pg.applicants@sussex.ac.uk
Related programmes
Fees and funding
Fees
Home UK/EU students: £5,5001
Channel Island and Isle of Man students: £5,5002
Overseas students: £16,2003
1
The fee shown is for the academic year 2013.
2
The fee shown is for the academic year 2013.
3
The fee shown is for the academic year 2013.
To find out about your fee status, living expenses and other costs, visit further financial information.
Funding
The funding sources listed below are for the subject area you are viewing and may not apply to all degrees listed within it. Please check the description of the individual funding source to make sure it is relevant to your chosen degree.
To find out more about funding and part-time work, visit further financial information.
Sussex Graduate Scholarship (2013)
Region: UK, Europe (Non UK), International (Non UK/EU)
Level: PG (taught)
Application deadline: 16 August 2013
Open to final year Sussex students who graduate with a 1st or 2:1 degree and who are offered a F/T place on an eligible Masters course in 2013.
Faculty interests
Dr John Armstrong Differentiation of fission yeast into mycelia, a model for pathogenic fungi, and autophagy, an important aspect of disease processes.
Professor John Atack The identification of drugs to treat disorders of the central nervous system including Alzheimer’s disease, schizophrenia, bipolar disorder and depression.
Professor Juan-Pablo Couso Molecular and developmental genetics. The study of limb development, analysing the molecular basis of proximal-distal pattern formation in Drosophila.
Dr Neil Crickmore, Bacillus thuringiensis Laboratory Our research is based on the bacterium Bacillus thuringiensis and its insecticidal toxins. We are interested in discovering and developing novel biological insecticides and in studying the interaction between these and their insect targets. We also use this bacterium and its host as a model system for studying a variety of ecological, physiological, biochemical and genetic processes.
Professor Tony Moore, Moore Laboratory Our research interests are focused on the structure and function of the alternative oxidases in plants and parasites. In particular, we are interested in how the structure of these important but enigmatic proteins influences their function in plants and parasites. Although this protein has been known for over 100 years, still relatively little is known about its mechanism of action or physiological significance. We are crystallising mutant and wild-type forms of the protein from both plants and human pathogens, which will provide structural and mechanistic clues as to its function in vivo.
Professor Simon Morley, Morley Laboratory We are investigating the signalling pathways regulating mRNA utilisation in eukaryotic cells during proliferation and differentiation. Our main focus is on the initiation factor complex, eIF4F, and its regulated assembly during different phases of the cell cycle. We are also developing tools to investigate localised protein synthesis in cells maintained in 2D and 3D culture. Although the regulation of protein synthesis is fundamental to cell growth and survival, relatively little is actually known about the role of phosphorylation of translation initiation factors in modulating this process.
Dr Mark Paget The Streptomyces bacteria mechanisms of sensing stress inputs and how these signals are transduced into regulatory outputs at the level of transcription and translation.
Dr Mark Roe, Roe Laboratory Our research is geared towards the understanding of structure and mechanism of proteins and protein complexes, in collaboration with other groups both in the University and from elsewhere.
Professor Louise Serpell, Serpell Laboratory We work on the structure and function of amyloidogenic proteins using a range of biophysical and imaging techniques.
Dr Alison Sinclair, Sinclair Laboratory We investigate the interactions between the Epstein-Barr Virus and host cells that direct whether the virus establishes latency and promotes cancer development or undergoes lytic replication, destroying the cell.
Dr Darren Thompson Using x-ray crystallography to determine the 3D structures of proteins. These structures also give us insights into the nature of interactions between ligands and their biological targets.
Dr Michael Titheradge Control of carbohydrate metabolism by bacterial lipopolysaccharides and proinflammatory cytokines during sepsis.
Dr Michelle West, West Laboratory We focus on deciphering the mechanisms involved in B-cell transformation by the cancer-associated herpes virus, Epstein-Barr Virus.
Careers and profiles
This MSc is a perfect platform for a career in research. Most of our graduates look to continue their studies as PhD students, often at Sussex, while others pursue careers as research assistants in the pharmaceutical industry or in a variety of academic research institutes.
Souvik's career perspective
‘The MSc in Genetic Manipulation and Molecular Cell Biology changed my life. From starting as a very ordinary student with an interest in biological science at genetic and molecular level it enabled me to become part of a neuroscience research team and a privileged contributor to a recently published research paper in the highly respected Journal of Neuroscience.
‘The faculty provided unstinting assistance and guidance. Right from the beginning as a struggling new student, through to submission of my MSc dissertation, I was fully supported.
‘The most significant aspect of the programme was being involved in an extended high-quality research project of my choice in the distinctively top-class labs at Sussex. I learned state-of-the-art techniques from my supervisor and I’m still working part-time in his lab, gaining expertise in different cell biology techniques and transgenic transfection in embryonic stem cell culture. I’m currently also working on molecular mechanism CamKII and its role in learning and memory, again at Sussex.
‘This fantastic programme takes you from the theoretical knowledge gained from your undergraduate degree, to the technical experiments and productive analysis you need to develop before pursuing a PhD, research position, or moving into a role in industry. It’s the perfect platform for your future career.’
Souvik Naskar
Research Technician,
University of Sussex
For more information, visit Careers and alumni.
School and contacts
School of Life Sciences
The School of Life Sciences provides an exciting and attractive environment for learning and research, with a thriving international community of students and academics.
Biochemistry and molecular biology,
School of Life Sciences, PG Admissions,
John Maynard Smith Building,
University of Sussex, Falmer,
Brighton BN1 9QG, UK
T +44 (0)1273 678057
E lifesci@sussex.ac.uk
School of Life Sciences: Biochemistry and molecular biology
Discover Postgraduate Study information sessions
You’re welcome to attend one of our Discover Postgraduate Study information sessions. These are held in the spring and summer terms and enable you to find out more about postgraduate study and the opportunities Sussex has to offer.
Visit Discover Postgraduate study to book your place.
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