Publications

Dr Matt Neale

Cooper, Tim J., Garcia, V., Neale, M. J.
Meiotic DSB Patterning: A multifaceted process
Cell Cycle 2016, Jan 5. doi: 10.1080/15384101.2015.1093709

Garcia V, Gray S, Allison RM, Cooper TJ, Neale MJ.
Tel1(ATM)-mediated interference suppresses clustered meiotic double-strand-break formation.
Nature 2015, Jan 5. doi: 10.1038/nature13993

Cooper, Tim JWardell, KayleighGarcia, Valerie and Neale, Matthew J.
Homeostatic regulation of meiotic DSB formation by ATM/ATR.
Experimental Cell Research 2014, 329 (1). pp. 124-131. ISSN 1090-2422

Shibata A, Moiani D, Arvai AS, Perry J, Harding SM, Genois MM, et al.
DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities.
Mol Cell 2013, Dec 3;53(1):7-18.

Gray S, Allison RM, Garcia V, Goldman AS, Neale MJ.
Positive regulation of meiotic DNA double-strand break formation by activation of the DNA damage checkpoint kinase mec1(ATR).
Open Biol 2013;3(7):130019.

Garcia, V., Phelps, S. P., Gray, S. and M. J. Neale.
Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1.
Nature 2011; 144(5): 719-731.

Pan, J., M. Sasaki, R. Kniewel, H. Murakami, H. G. Blitzblau, S. E. Tischfield, X. Zhu, M. J. Neale, M. Jasin, N. D. Socci, A. Hochwagen, and S. Keeney.
A Hierarchical Combination of Factors Shapes the Genome-wide Topography of Yeast Meiotic Recombination Initiation.
Cell 2011; 144(5): 719-731.

Neale, M. J.
PRDM9 points the zinc finger at meiotic recombination hotspots.
Genome Biology 2010; 11: 104.

Terentyev, Y., R. Johnson, M. J. Neale, M. Khisroon, A. Bishop-Bailey and A. S. H. Goldman.
Evidence that MEK1 positively promotes interhomologue double-strand break repair.
Nucleic Acids Research 2010; 38(13): 4349-4360.

Hartsuiker, E., M. J. Neale and A. M. Carr.
Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA.
Molecular Cell 2009; 33(1):117-123

Neale, M. J. and S. Keeney.
End-labelling and Analysis of Spo11-Oligonucleotide Complexes in Saccharomyces cerevisiae.
Methods in Molecular Biology 2009; 557:183-195.

Johnson, R., V. Borde, M. J. Neale, A. Bishop-Bailey, M. North, S. Harris, A. Nicolas and A. S. Goldman
Excess single-stranded DNA inhibits meiotic double-strand break repair.
PLoS Genet 2007; 3(11): e223 doi:10.1371/journal.pgen.0030223

Maleki, S., M. J. Neale, C. Arora, K. A. Henderson and S. Keeney
Interactions between Mei4, Rec114, and other proteins required for meiotic DNA double-strand break formation in Saccharomyces cerevisiae.
Chromosoma 2007; 116(5): 471-86.

Neale, M. J. and S. Keeney
Clarifying the mechanics of DNA strand exchange in meiotic recombination.
Nature 2006; 442(7099): 153-8.

Keeney, S. and M. J. Neale
Initiation of meiotic recombination by formation of DNA double-strand breaks: Mechanism and regulation.
Biochem Soc Trans. 2006; 34(Pt 4): 523-5.

Neale, M. J., J. Pan and S. Keeney
Endonucleolytic processing of covalent protein-linked DNA double-strand breaks.
Nature 2005; 436(7053): 1053-7.

Neale, M. J., M. Ramachandran, E. Trelles-Sticken, H. Scherthan and A. S. Goldman
Wild-type levels of Spo11-induced DSBs are required for normal single-strand resection during meiosis
Molecular Cell 2002; 9(4): 835-46.

Available from SRO: 

Article

Johnson, Dominic, Crawford, Margaret, Cooper, Tim, Claeys Bouuaert, Corentin, Keeney, Scott, Llorente, Bertrand, Garcia, Valerie and Neale, Matthew J (2021) Concerted cutting by Spo11 illuminates meiotic DNA break mechanics. Nature, 594. pp. 572-576. ISSN 0028-0836

Bergero, Roberta, Ellis, Peter, Haerty, Wilfried, Larcombe, Lee, Macaulay, Iain, Mehta, Tarang, Mogensen, Mette, Murray, David, Nash, Will, Neale, Matthew J, O'Connor, Rebecca, Ottolini, Christian, Peel, Ned, Ramsey, Luke, Skinner, Ben and others, (2021) Meiosis and beyond – understanding the mechanistic and evolutionary processes shaping the germline genome. Biological Reviews, 96 (3). pp. 822-841. ISSN 1464-7931

Paldi, Flora, Alver, Bonnie, Robertson, Daniel, Schalbetter, Stephanie A, Kerr, Alastair, Kelly, David A, Baxter, Jonathan, Neale, Matthew J and Marston, Adele L (2020) Convergent genes shape budding yeast pericentromeres. Nature, 582. pp. 119-123. ISSN 0028-0836

Gittens, William H, Johnson, Dominic J, Allison, Rachal M, Cooper, Tim J, Thomas, Holly and Neale, Matthew J (2019) A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome. Nature Communications, 10. a4846. ISSN 2041-1723

Schalbetter, Stephanie A, Fudenberg, Geoffrey, Baxter, Jonathan, Pollard, Katherine S and Neale, Matthew J (2019) Principles of meiotic chromosome assembly revealed in S. cerevisiae. Nature Communications, 10. a4795. ISSN 2041-1723

Cannavo, Elda, Johnson, Dominic, Andres, Sara, Kissling, Vera, Reinert, Julia, Garcia, Valerie, Erie, Dorothy, Hess, Daniel, Thomä, Nicolas, Enchev, Radoslav, Peter, Matthias, Williams, Scott, Neale, Matt and Cejka, Petr (2018) Regulatory control of DNA end resection by Sae2 phosphorylation. Nature Communications, 9. p. 4016. ISSN 2041-1723

Cooper, Tim J, Garcia, Valerie and Neale, Matthew J (2016) Meiotic DSB patterning: A multifaceted process. Cell Cycle, 15 (1). pp. 13-21. ISSN 1538-4101

Garcia, Valerie, Gray, Stephen, Allison, Rachal M, Cooper, Tim J and Neale, Matthew J (2015) Tel1(ATM)-mediated interference suppresses clustered meiotic double-strand-break formation. Nature, 520 (7545). pp. 114-118. ISSN 1476-4687

Cooper, Tim J, Wardell, Kayleigh, Garcia, Valerie and Neale, Matthew J (2014) Homeostatic regulation of meiotic DSB formation by ATM/ATR. Experimental Cell Research, 329 (1). pp. 124-131. ISSN 1090-2422

Shibata, Atsushi, Moiani, Davide, Arvai, Andrew S, Perry, Jefferson, Harding, Shane M, Genois, Marie-Michelle, Maity, Ranjan, van Rossum-Fikkert, Sari, Kertokalio, Aryandi, Romoli, Filipo, Ismail, Amani, Ismalaj, Ermal, Petricci, Elena, Neale, Matthew J, Bristow, Robert G, Masson, Jean-Yves, Wyman, Claire, Jeggo, Penny and Tainer, John A (2014) DNA double-strand break repair pathway shoice is directed by distinct MRE11 nuclease activities. Molecular Cell, 53 (1). pp. 7-18. ISSN 1097-2765

Shibata, Atsushi, Moiani, Davide, Arvai, Andrew S, Perry, Jefferson, Harding, Shane M, Genoise, Marie-Michelle, Maity, Ranjan, van Rossum-Fikkert, Sari, Kertokalio, Aryandi, Romoli, Filippo, Ismail, Amani, Ismalaj, Ermal, Neale, Matthew J, Bristow, Robert G, Masson, Jean-Yves, Wyman, Claire, Jeggo, Penny A, Tainer, John A and Petricci, Elena (2013) DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Molecular Cell, 53 (1). pp. 7-18. ISSN 1097-2765

Gray, Stephen, Allison, Rachal M, Garcia, Valerie, Goldman, Alastair S H and Neale, Matthew J (2013) Positive regulation of meiotic DNA double-strand break formation by activation of the DNA damage checkpoint kinase Mec1(ATR). Open Biology, 3 (7). p. 130019. ISSN 2046-2441

Garcia, V, Phelps, S E, Gray, S and Neale, M J (2011) Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1. Nature, 478 (7369). pp. 241-244. ISSN 0028-0836

Pan, J, Sasaki, M, Kniewel, R, Murakami, H, Blitzblau, H.G, Tischfield, S.E, Zhu, X, Neale, Matt, Jasin, M, Socci, N.D, Hochwagen, A and Keeney, S (2011) A hierarchical combination of factors shapes the genome-wide topography of yeast meiotic recombination initiation. Cell, 114 (5). pp. 719-731. ISSN 00928674

Hartsuiker, Edgar, Neale, Matthew J and Carr, Antony M (2009) Distinct requirements for the Rad32(Mre¹¹) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA. Molecular Cell, 33 (1). pp. 117-123. ISSN 1097-2765

Neale Lab publications with abstracts and links

PubMed