Biography

Background:

BA PhD (London)

Key responsibilities:

Course organiser: Genome stability, genetic diseases and cancer

Chairman: Genome damage and stability centre

Role

http://www.sussex.ac.uk/lifesci/lehmannlab/

1. Replication of damaged DNA. Y-family DNA polymerases and relation to human disorders.

2. Genetic disorders with defects in DNA repair and transcription: Xeroderma pigmentosum, Cockayne Syndrome and trichothiodystrophy.

3. SMC protein involved in DNA repair in yeast and man.

For further information, see Genome Damage and Stability web-page

Niimi, Atsuko, Chambers, Anna L, Downs, Jessica A and Lehmann, Alan R (2012) A role for chromatin remodellers in replication of damaged DNA. Nucleic Acids Research, 40 (15). pp. 7393-7403. ISSN 0305-1048

Nakazawa, Yuka, Sasaki, Kensaku, Mitsutake, Norisato, Matsuse, Michiko, Shimada, Mayuko, Nardo, Tiziana, Takahashi, Yoshito, Ohyama, Kaname Ohyama, Ito, Kosei, Mishima, Hiroyuki, Nomura, Masayo, Kinoshita, Akira, Ono, Shinji, Takenaka, Katsuya, Masuyama, Ritsuko, Kudo, Takashi, Slor, Hanoch, Utani, Atsushi, Tateishi, Satoshi, Yamashita, Shunichi, Stefanini, Miria, Lehmann, Alan R, Yoshiura, Koh-ichiro and Ogi, Tomoo (2012) Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair. Nature Genetics, 44 (5). pp. 586-592. ISSN 1061-4036

Lehmann, Alan R (2012) DNA repair, DNA replication and human disorders: A personal journey. DNA Repair, 11 (4). pp. 328-334. ISSN 1568-7864

Sale, Julian E, Lehmann, Alan R and Woodgate, Roger (2012) Y-family DNA polymerases and their role in tolerance of cellular DNA damage. Nature Reviews Molecular Cell Biology, 13. pp. 141-152. ISSN 1471-0072

Niimi, Atsuko, Chambers, Anna L, Downs, Jessica A and Lehmann, Alan R (2012) A role for chromatin remodellers in replication of damaged DNA. Nucleic Acids Research, 40 (15). pp. 7393-7403. ISSN 0305-1048

Lehmann, Alan R (2011) Ubiquitin-family modifications in the replication of DNA damage. FEBS Letters, 585 (18). pp. 2772-2779. ISSN 0014-5793

Göhler, Thomas, Sabbioneda, Simone, Green, Catherine M and Lehmann, Alan R (2011) ATR-mediated phosphorylation of DNA polymerase η is needed for efficient recovery from UV damage. Journal of Cell Biology, 192 (2). pp. 219-227. ISSN 0021-9525

Lehmann, Alan R, McGibbon, David and Stefanini, Miria (2011) Xeroderma Pigmentosum. Orphanet Journal of Rare Diseases, 6. ISSN 1750-1172

Coulon, Stéphane, Ramasubramanyan, Sharada, Alies, Carole, Philippin, Gaëlle, Lehmann, Alan and Fuchs, Robert P (2010) Rad8Rad5/Mms2-Ubc13 ubiquitin ligase complex controls translesion synthesis in fission yeast. EMBO Journal, 29 (12). pp. 2048-2058. ISSN 0261-4189

Bienko, Marzena, Green, Catherine M, Sabbioneda, Simone, Crosetto, Nicola, Matic, Ivan, Hibbert, Richard G, Begovic, Tihana, Niimi, Atsuko, Mann, Matthias, Lehmann, Alan R and Dikic, Ivan (2010) Regulation of translesion synthesis DNA polymerase η by monoubiquitination. Molecular Cell, 37 (3). pp. 396-407. ISSN 1097-2765

Laugel, V, Dalloz, C, Durand, M, Sauvanaud, F, Kristensen, U, Vincent, M C, Pasquier, L, Odent, S, Cormier-Daire, V, Gener, B, Tobias, E S, Tolmie, J L, Martin-Coignard, D, Drouin-Garraud, V, Heron, D, Journel, H, Raffo, E, Vigneron, J, Lyonnet, S, Murday, V, Gubser-Mercati, D, Funalot, B, Brueton, L, Sanchez del Polo, J, Muñoz, E, Gennery, A R, Salih, M, Noruzina, M, Prescott, K, Ramos, L, Stark, Z, Fieggen, K, Chabrol, B, Sarda, P, Edery, P, Bloch-Zupan, A, Fawcett, F, Pham, D, Egly, J M, Lehmann, A R, Sarasin, A and Dollfus, H (2010) Mutation Update for the CSB/ERCC6 and CSA/ERCC8 Genes Involved in Cockayne Syndrome. Human Mutation, 31 (2). pp. 113-126. ISSN 1059-7794

Laugel, V, Dalloz, C, Durand, M, Sauvanaud, F, Kristensen, U, Vincent, M C, Pasquier, L, Odent, S, Cormier-Daire, V, Gener, B, Tobias, E S, Tolmie, J L, Martin-Coignard, D, Drouin-Garraud, V, Heron, D, Journel, H, Raffo, E, Vigneron, J, Lyonnet, S, Murday, V, Gubser-Mercati, D, Funalot, B, Sanchez del Pozo, J, Muñoz, E, Gennery, A R, Salih, M, Noruzinia, M, Prescott, K, Ramos, L, Stark, Z, Fieggen, K, Chabrol, B, Sarda, P, Edery, P, Bloch-Zupan, A, Fawcett, H, Pham, D, Egly, J M, Lehmann, A R, Sarasin, A and Dollfus, H (2010) Mutation update for the CSB/ERCC6 and CSA/ERCC8 genes involved in Cockayne syndrome. Human Mutation, 31 (2). pp. 113-126. ISSN 1059-7794

Forsythe, Elizabeth, Wild, Ruth, Sellick, Gabrielle, Houlston, Richard S., Lehmann, Alan R. and Wakeling, Emma (2009) A novel DNA repair disorder with thrombocytopenia, nephrosis and features overlapping Cockayne syndrome. American Journal of Medical Genetics Part A, 149A (10). pp. 2075-2079. ISSN 1552-4825

Limsirichaikul , Siripan, Niimi, Atsuko, Fawcett, Heather, Lehmann, Alan, Yamashita, Shunichi and Ogi, Tomoo (2009) A rapid non-radioactive technique for measurement of repair synthesis in primary human fibroblasts by incorporation of Ethynyl deoxyuridine (EdU). Nucleic Acids Research, 37 (4). ISSN 0305-1048

Lehmann, Alan R. (2008) XPD structure reveals its secrets. DNA Repair, 7 (11). pp. 1912-1915. ISSN 1568-7864

Niimi, Atsuko, Brown, Stephanie, Sabbioneda, Simone, Kannouche, Patricia L., Scott, Andrew, Yasui, Akira, Green, Catherine M. and Lehmann, Alan R. (2008) Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells. Proceedings of the National Academy of Sciences, 105 (42). pp. 16125-16130. ISSN 0027-8424

Botta, Elena, Offman , Judith, Nardo, Tiziana, Ricotti, Roberta, Zambruno, Giovanna, Sansone, Daniela, Balestri, Paolo, Raams, Anja, Kleijer, Wim J., Jaspers, Nicolaas G.J., Sarasin, Alain, Lehmann, Alan R. and Stefanini, Miria (2007) Mutations in the C7orf11 (TTDN1) Gene in Six Nonphotosensitive Trichothiodystrophy Patients: No Obvious Genotype-Phenotype Relationships. Human Mutation, 28 (1). pp. 92-96. ISSN 1059-7794

Lehmann, Alan R. and Fuchs, Robert P. (2006) Gaps and forks in DNA replication: Rediscovering old models. DNA Repair, 5 (12). pp. 1495-1498. ISSN 1568-7864

Oh, Kyu-Seon, Khan, Sikandar G., Jaspers, N.G.J., Raams, Anja, Ueda, Takahiro, Lehmann, Alan, Friedmann, Peter S., Emmert, Steffen, Gratchev, Alexi, Lachlan, Katherine, Lucassan, Anneke, Baker, Carl C. and Kraemer, Kenneth H. (2006) Phenotypic Heterogeneity in the XPB DNA Helicase Gene (ERCC3): Xeroderma Pigmentosum Without and With Cockayne Syndrome. Human Mutation, 27 (11). pp. 1092-1103. ISSN 1059-7794

Lehmann, Alan R. (2006) Translesion synthesis in mammalian cells. Experimental Cell Research, 312 (14). pp. 2673-2676. ISSN 0014-4827

Andressoo, Jaan-Olle, Mitchell, James R., de Wit, Jan, Hoogstraten, Deborah, Volker, Marcel, Toussaint, Wendy, Speksnijder, Ewoud, Beems, Rudolph B., van Steeg, Harry, Jans, Judith, de Zeeuw, Chris I., Jaspers, Nicolaas G.J., Raams, Anja, Lehmann, Alan R., Vermeulen, 19651, Hoeijmakers, Jan H.J. and van der Horst, Gijsbertus T.J. (2006) An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria. Cancer Cell, 10 (2). pp. 121-132. ISSN 1535-6108

Arlett, C. F., Plowman, P. N., Rogers, P. B., Parris, C. N., Abbaszadeh, F., Green, M. H. L., McMillan, T.J., Bush, C., Foray, N. and Lehmann, A. R. (2006) Clinical and cellular ionizing radiation sensitivity in a patient with xeroderma pigmentosum. British Journal of Radiology , 79 (942). pp. 510-517. ISSN 0007-1285

Theron, Therina, Fousteri, Maria I., Volker, Marcel, Harries, Lorna W., Botta, Elena, Stefanini, Miria, Fujimoto, Mitsuo, Andressoo, Jaan-Olle, Mitchell, Jay, Jaspers, Nicolaas G. J., McDaniel, Lisa D., Mullenders, Leon H. and Lehmann, Alan R. (2005) Transcription-Associated Breaks in Xeroderma Pigmentosum Group D Cells from Patients with Combined Features of Xeroderma Pigmentosum and Cockayne Syndrome. Molecular and Cellular Biology, 25 (18). pp. 8368-8378. ISSN 0270-7306

Lehmann, Alan R. (2005) The role of SMC proteins in the responses to DNA damage. DNA Repair , 4 (3). pp. 309-314. ISSN 1568-7864

Sergeant, John, Taylor, Elaine, Palecek, Jan, Fousteri, Maria, Andrews, Emily A., Sweeney, Sara, Shinagawa, Hideo, Watts, Felicity Z. and Lehmann, Alan R. (2005) Composition and Architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) Complex. Molecular and Cellular Biology, 25 (1). pp. 172-184. ISSN 0270-7306

Albertella, Mark R., Green, Catherine M., Lehmann, Alan R. and O'Connor, Mark J. (2005) A Role for Polymerase η in the Cellular Tolerance to Cisplatin-Induced Damage. Cancer Research, 65 (21). pp. 9799-806. ISSN 0008-5472

Fujimoto, Mitsuo, Leech, Suzanne N., Theron, Therina, Mori, Masato, Fawcett, Heather, Botta, Elena, Nozaki, Yasuyuki, Yamagata, Takanori, Moriwaki, Shin-Ichi, Stefanini, Miria, Momoi, Mariko Y., Nakagawa, Hidemi, Shuster, Sam, Moss, Celia and Lehmann, Alan R. (2005) Two New XPD Patients Compound Heterozygous for the Same Mutation Demonstrate Diverse Clinical Features. Journal of Investigative Dermatology, 125 (1). pp. 86-92. ISSN 0022-202x

Kannouche, Patricia L, Wing, Jonathan and Lehmann, Alan R (2004) Interaction of Human DNA Polymerase η with Monoubiquitinated PCNA: A Possible Mechanism for the Polymerase Switch in Response to DNA Damage. Molecular Cell, 14 (4). pp. 491-500. ISSN 1097-2765

Lehmann, Alan (2003) Watson and DNA: Making a Scientific Revolution: Victor McElheny, Perseus Publishing, Cambridge, MA, ISBN 0-7382-0341-6. DNA Repair , 2 (9). pp. 1073-1074. ISSN 1568-7864

Lehmann, Alan R. (2003) Replication of Damaged DNA. Cell Cycle, 2 (4). pp. 300-302. ISSN 1538-4101

Broughton, Bernard C, Cordonnier, Agnes, Kleijer, Wim J, Jaspers, Nicolaas G J, Fawcett, Heather, Raams, Heather, Garritsen, Victor H., Stary, Anne, Avril, Marie-Francoise, Boudsocq, Francois, Masutani, Chikahide, Hanaoka, Fumio, Fuchs, Robert P, Sarasin, Alain and Lehmann, Alan R (2002) Molecular analysis of mutations in DNA polymerase η in xeroderma pigmentosum-variant patients. Proceedings of the National Academy of Sciences of the United States of America , 99 (2). pp. 815-820. ISSN 1091-6490

Botta, Elena, Nardo, Tiziana, Lehmann, Alan R., Egly, Jean-Marc, Pedrini, Antonia M. and Stefanini, Miria (2002) Reduced level of the repair/transcription factor TFIIH in trichothiodystrophy. Human Molecular Genetics, 11 (23). pp. 2919-2928. ISSN 0964-6906

Kannouche, Patricia, Broughton, Bernard C, Volker, Marcel, Hanaoka, Fumio, Mullenders, Leon H F and Lehmann, Alan R (2001) Domain structure, localization, and function of DNA polymerase η, defective in xeroderma pigmentosum variant cells. Genes and Development, 15 (2). pp. 158-172. ISSN 0890-9369

Broughton, Bernard C, Berneburg, Mark, Fawcett, Heather, Taylor, Elaine M, Arlett, Colin F, Nardo, Tiziana, Stefanini, Miria, Menefee, Emory, Price, Vera H, Queille, Sophie, Sarasin, Alain, Bohnert, Elisabeth, Krutmann, Jean, Davidson, Rosemarie, Kraemer, Kenneth H and Lehmann, Alan R (2001) Two individuals with features of both xeroderma pigmentosum and trichothiodystrophy highlight the complexity of the clinical outcomes of mutations in the XPD gene. Human Molecular Genetics, 10 (22). pp. 2539-2547. ISSN 0964-6906

Broughton, Bernard C., Berneburg, Mark, Fawcett, Heather, Taylor, Elaine M., Arlett, Colin F., Nardo, Tiziana, Stefanini, Miria, Menefee, Emory, Price, Vera H., Queille, Sophie, Sarasin, Alain, Bohnert, Elisabeth, Krutmann, Jean, Davidson, Rosemarie, Kraemer, Kenneth H. and Lehmann, Alan R. (2001) Two individuals with features of both xeroderma pigmentosum and trichothiodystrophy highlight the complexity of the clinical outcomes of mutations in the XPD gene. Human Molecular Genetics, 10 (22). pp. 2539-2547. ISSN 0964-6906

Riballo, E, Critchlow, S E, Teo, S-H, Doherty, A J, Priestley, A, Broughton, B, Kysela, B, Beamish, H, Plowman, N, Arlett, C F, Lehmann, A R, Jackson, S P and Jeggo, P A (1999) Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient. Current Biology, 9 (13). 699 - 702. ISSN 0960-9822

Blunt, Tracy, Gell, David, Fox, Margaret, Taccioli, Guillermo E, Lehmann, Alan R, Jackson, Stephen P and Jeggo, Penny A (1996) Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the i scid mouse. Proceedings of the National Academy of Sciences of the United States of America, 93. 10285 - 10290. ISSN 0027-8424