Biography

External Activities:

Editorial duties:
 

Role

Director, Genome Damage and Stability Centre

Whave, along with others developed S. pombe as a model system for studying DNA damage responses. Our current work focuses on the links between checkpoint, cell cycle, replication and recombination repair pathways.

Our recent papers:

• Holmberg, C., Fleck, O., Hansen, H.A., Liu, C., Slaaby, R., Carr, A.M. and Nielsen O. (2005) Ddb1 controls genome stability and meiosis in fission yeast. Genes Dev. 19, 853-62.
• Lambert, S., Watson, A., Sheedy, D.M., Martin, B. and Carr, A.M. (2005) Gross Chromosomal Rearrangements and Elevated Recombination at an Inducible Site Specific Replication Fork Barrier. Cell 121, 689-702.
• Morishita, T., Furukawa, F., Sakaguchi1, C., Toda, T., Carr, A.M., Iwasaki, H., Shinagawa, H. (2005) Role of the Schizosaccharomyces pombe F-box DNA helicase in processing recombination intermediates. Mol. Cell Biol, 25, 8074-8083.
• Hentges, P., Van Driessche, B., Tafforeau, L., Vandenhaute, J., Carr, A.M. (2005) Three novel antibiotic marker cassettes for gene disruption and marker switching in Schizosaccharomyces pombe. Yeast 22, 1013-1019.
• Van Driessche, B., Tafforeau, L., Hentges, P., Carr, A.M., Vandenhaute, J. (2005) Additional vectors for PCR-based gene tagging in Saccharomyces cerevisiae and Schizosaccharomyces pombe using nourseothricin resistance. Yeast, 22 1061-1068.
• Liu, C., Poitelea, M., Watson, A., Yoshida, S., Shimoda, C., Holmberg, C., Nielsen, O. and Carr, A.M. (2005) Transactivation of Schizosaccharomyces pombe cdt2⁺ stimulates a Pcu4-Ddb1-CSN ubiquitin ligase. EMBO J. 24, 3940-3951.
• Frampton, J., Irmisch, A., Green, C.M., Neiss, A., Trickey, M., Ulrich, H.D., Furuya, K., Watts, F.Z., Carr, A.M. and Lehmann, A.R. (2006) Postreplication repair and PCNA modification in Schizosaccharomyces pombe. Mol Biol Cell. 17, 2976-85.
• Opel, M., Lando, D., Bonilla, C., Trewick, S.C., Boukaba, A., Walfridsson, J., Cauwood, J., Werler, P.J.H., Carr, A.M., Kouzarides, T., Murzina, N.V., Allshire, R.C., Ekwall, K. and Laue, E.D. (2007) Genome-wide studies of histone demethylation catalysed by the fission yeast homologues of mammalian LSD1. PLoS 4, e386.
• Kai, M., Furuya, K., Paderi, F., Carr, A.M. and Wang, T. (2007) Rad3-dependent phosphorylation of the checkpoint clamp regulates repair-pathway choice. Nat. Cell. Biol. 9, 691-697.
• Watson, A.T., Garcia , V., Bone, N., *Carr, A.M. and Armstrong, J. (2007) Gene tagging and gene replacement using recombinase-mediated cassette exchange in Schizosaccharomyces pombe. Gene, In press.

For more information, see the Genome Damage and Stability Centre.

Mizuno, Ken'ichi, Miyabe, Izumi, Schalbetter, Stephanie, Carr, Antony and Murray, Johanne (2013) Recombination-restarted replication makes inverted chromosome fusions at inverted repeats. Nature, 493. pp. 246-249. ISSN 0028-0836

Mizuno, Ken'ichi, Miyabe, Izumi, Schalbetter, Stephanie A, Carr, Antony M and Murray, Johanne M (2013) Recombination-restarted replication makes inverted chromosome fusions at inverted repeats. Nature, 493 (7431). pp. 246-249. ISSN 0028-0836

Tang, Zhaohua, Luca, Maria, Taggart-Murphy, Laura, Portillo, Jessica, Chang, Cathey, Guven, Ayse, Lin, Ren-Jang, Murray, Johanne and Carr, Antony (2012) Interacting factors and cellular localization of SR protein-specific kinase Dsk1. Experimental Cell Research, 318 (16). pp. 2071-2084. ISSN 0014-4827

Lando, David, Endesfelder, Ulrike, Berger, Harald, Subramanian, Lakxmi, Dunne, Paul D, McColl, James, Klenerman, David, Carr, Antony M, Sauer, Markus, Allshire, Robin C, Heilemann, Mike and Laue, Ernest D (2012) Quantitative single-molecule microscopy reveals that CENP-A(Cnp1) deposition occurs during G2 in fission yeast. Open Biology, 2 (7). p. 120078. ISSN 2046-2441

Lin, Su-Jiun, Wardlaw, Christopher Paul, Morishita, Takashi, Miyabe, Izumi, Chahwan, Charly, Caspari, Thomas, Schmidt, Ulrike, Carr, Antony and Garcia, Valerie (2012) The Rad4TopBP1 ATR-Activation domain functions in G1/S phase in a chromatin-dependent manner. PLoS Genetics, 8 (6). ISSN 1553-7390

Hu, Jiazhi, Sun, Lei, Shen, Fenfen, Chen, Yufei, Hua, Yu, Liu, Yang, Zhang, Mian, Hu, Yiren, Wang, Qingsong, Xu, Wei, Sun, Fei, Ji, Jianguo, Murray, Johanne M, Carr, Antony M and Kong, Daochun (2012) The intra-S phase checkpoint targets Dna2 to prevent stalled replication forks from reversing. Cell, 149 (6). pp. 1221-1232. ISSN 1097-4172

Miyabe , Izumi, Kunkel, Thomas A and Carr, Antony M (2011) The major roles of DNA polymerases epsilon and delta at the eukaryotic replication fork are evolutionarily conserved. PLoS Genetics, 7 (12). e1002407. ISSN 1553-7390

Mizuno, Ken'ichi, Lambert, Sarah, Baldacci, Giuseppe, Murray, Johanne M and Carr, Antony M (2009) Nearby inverted repeats fuse to generate acentric and dicentric palindromic chromosomes by a replication template exchange mechanism. Genes and Development , 23 (24). pp. 2876-2886. ISSN 0890-9369

Lloyd, Janette, Chapman, J. Ross, Clapperton, Julie A., Haire, Lesley F., Hartsuiker, Edgar, Li, Jiejin, Carr, Antony M., Jackson, Stephen P. and Smerdon, Stephen J. (2009) A supramodular FHA/BRCT-Repeat architecture mediates Nbs1 adaptor function in response to DNA damage. Cell, 139 (1). pp. 100-111. ISSN 0092-8674

Miyabe, Izumi, Morishita, Takashi, Shinagawa, Hideo and Carr, Antony M (2009) Schizosaccharomyces pombe Cds1 regulates homologous recombination at stalled replication forks through the phosphorylation of recombination protein Rad60. Journal of Cell Science, 122. pp. 3638-3643. ISSN 0021-9533

Dziadkowiec, Dorota, Petters, Edyta, Dyjankiewicz, Agnieszka, Karpinski, Pawel, Garcia, Valerie, Watson, Adam T. and Carr , Antony M. (2009) The role of novel genes rrp1(+) and rrp2(+) in the repair of DNA damage in Schizosaccharomycespombe. DNA Repair, 8 (5). pp. 627-636. ISSN 1568-7864

Hartsuiker, Edgar, Mizuno, Kenichi, Molnar, Monika, Kohli, Juerg, Ohta , Kunihiro and Carr, Antony M (2009) Ctp1(CtIP) and Rad32(Mre11) nuclease activity are required for Rec12(Spo11) removal, but Rec12(Spo11) removal Is dispensable for other MRN-Dependent meiotic functions. Molecular and Cellular Biology, 29 (7). pp. 1671-1681. ISSN 0270-7306

Hishida, T, Kubota, Y, Carr, Antony M and Iwasaki, H (2009) RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light. Nature, 457 (7229). pp. 612-615. ISSN 0028-0836

Holmberg, Christian, Fleck, Oliver, Hansen, Heidi A, Liu, Cong, Slaaby, Rita, Carr , Antony M and Nielsen, Olaf (2005) Ddb1 controls genome stability and meiosis in fission yeast. Genes and Development, 19 (7). pp. 853-862. ISSN 0890-9369

Caspari, Thomas, Murray, Johanne M and Carr, Antony M (2002) Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III. Genes and Development, 16 (10). pp. 1195-208. ISSN 0890-9369

Marchetti, Maria A, Kumar, Sanjay, Hartsuiker, Edgar, Maftahi, Mohamed, Carr, Antony M, Freyer, Greg A, Burhans, William C and Huberman, Joel A (2002) A single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway. Proceedings of the National Academy of Sciences, 99 (11). pp. 7472-7477. ISSN 1091-6490

Mundt, Kirsten E, Porte, Joanne, Murray, Johanne M, Brikos, Constantinos, Christensen, Per U, Caspari, Thomas, Hagan, Iain M, Millar, Jonathan B A, Simanis, Viesturs, Hofmann, Kay and Carr, Anthony M (1999) The COP9/signalosome complex is conserved in fission yeast and has a role in S phase. Current Biology, 9 (23). pp. 1427-1430.

Lindsay, Howard D, Griffiths, Dominic J, Edwards, Rhian J, Christensen, Per U, Murray, Johanne M, Osman, Fekret, Walworth, Nancy and Carr, Antony M (1998) S-phase-specific activation of Cds1 kinase defines a subpathway of the checpoint response in Schizosaccharomyces pombe. Genes and Development, 12 (3). pp. 382-395. ISSN 0890-9369