Biography

EMBO Young Investigator, GDSC, University of Sussex (2013-2015)

MRC Senior Non-clinical Research Fellow, GDSC, University of Sussex (2010-2015)

Royal Society Dorothy Hodgkin Fellow, GDSC, University of Sussex (2005-2010)

EMBO Visiting Fellow, Yale University, USA (2005) 

Postdoctoral Research Associate, University of Leicester, UK (2002-2005) 

D. Phil. (Biochemistry), University of Oxford, UK (1998-2002)

B.A. (Biological Sciences),  University of Oxford, UK (1995-1998) 

Role

Principal Investigator, MRC Senior Non-clinical Research Fellow & EMBO Young Investigator

My lab is interested in proteins that promote crossing over during meiosis and mitosis.

 We have recently identified novel functions of crossover-promoting proteins Msh4-Msh5 and Zip1 in the segregation of chromosome pairs during the first meiotic division. The regulation of this process is particular important as defective segregation leads to birth defects and infertility in human. We are using budding yeast as a model system and this work is funded by the BBSRC and the MRC.

Mlh1 is a mismatch-repair protein that also promotes crossing over during meiosis. However, in mitotically-dividing cells, inactivation of Mlh1 and other mismatch repair proteins cause cells to display resistance to cis-platin, an anti-tumour drug. We are currently trying to understand how Mlh1 and other mismatch repair proteins sensitise cells to cis-platin. This work is funded by Cancer Research UK and the Royal Society.

Genetics & Genomics (2nd Year, Lifesciences): Meiosis, chromosome dynamics, and classical genetics.

Genome Damage and Human Disease (3rd Year, Lifesciences): Mismatch repair and cancer.

Student Consultation

Please arrange for consulation times directly with me, if needed

Newcombe, Sonya, Bobin, Mariusz, Shrikhande, Amruta, Gallop, Chris, Pace, Yannick, Yong, Helen, Gates, Rebecca, Chaudhuri, Shuvashri, Roe, Mark, Hoffmann, Eva and Viseux, Eddy M E (2013) Gold amides as anticancer drugs: synthesis and activity studies. Organic and Biomolecular Chemistry, 19 (11). pp. 3255-3260. ISSN 1477-0520

Hoffmann, Eva (2011) Chromosome Recombination. Seminars in Cell and Developmental Biology, 22 (8). p. 865. ISSN 1084-9521

Gatz, Susanne A, Ju, Limei, Gruber, Ralph, Hoffmann, Eva, Carr, Antony M, Wang, Zhao-Qi, Liu, Cong and Jeggo, Penny A (2011) Requirement for DNA Ligase IV during Embryonic Neuronal Development. Journal of Neuroscience, 31. pp. 10088-100100.

Watts, Felicity Z and Hoffmann, Eva (2011) SUMO meets meiosis: An encounter at the synaptonemal complex. BioEssays, 33. pp. 529-537. ISSN 0265-9247

Cotton, Victoria E, Hoffmann, Eva R and Borts, Rhona H (2010) Distinct regulation of Mlh1p heterodimers in meiosis and mitosis in Saccharomyces cerevisiae. Genetics, 185. pp. 459-467. ISSN 0016-6731

Falk, Jill E, Chan, Andrew Chi-ho, Hoffmann, Eva and Hochwagen, Andreas (2010) A Mec1- and PP4-dependent checkpoint couples centromere pairing to meiotic recombination. Developmental Cell, 19. pp. 599-611.

Newnham, Louise, Jordan, Philip, Rockmill, Beth, Roeder, G Shirleen and Hoffmann, Eva (2010) The synaptonemal complex protein, Zip1 promotes the segregation of nonexchange chromosomes at meiosis I. Proceedings of the National Academy of Sciences , 107 (2). pp. 781-785. ISSN 1091-6490

Jordan, P, Copsey, A, Newnham, L, Kolar, E, Lichten, M. and Hoffmann, Eva (2009) Ipl1/Aurora B kinase coordinates synaptonemal complex disassembly with cell cycle progression and crossover formation in budding yeast meiosis. Genes and Development, 23. pp. 2237-2251. ISSN 0890-9369

Jordan, Philip, Copsey, Alice, Newnham, Louise, Kolar, E., Lichten, M. and Hoffmann, Eva (2009) Ipl1/Aurora B kinase coordinates synaptonemal complex disassembly with cell cycle progression and crossover formation in budding yeast meiosis. Genes and Development, 23 (18). pp. 2237-2251. ISSN 0890-9369

Clyne, M, Offman, J, Shanley, S, Virgo, J D, Radulovic, M, Wang, Y, Ardern-Jones, A, Eeles, R, Hoffman, E, Yu, V P C C and Unset (2009) The G67E mutation in hMLH1 is associated with an unusual presentation of Lynch syndrome. British Journal of Cancer. ISSN 0007-0920

Jordan, Philip, Copsey, Alice, Newnham, Louise, Kolar, Eizabeth, Michael, Lichten and Hoffmann, Eva (2009) Ipl1/Aurora B kinase coordinates synaptonemal complex disassembly with cell cycle progression and crossover formation in budding yeast meiosis. Genes and Development, 23 (18). pp. 2237-2251. ISSN 0890-9369

Chan, Andrew Chi-ho, Borts, Rhona H and Hoffmann, Eva (2009) Temperature-dependent modulation of interference and chromosome segregation in msh4 mutants of budding yeast. PLoS ONE, 4. e7284. ISSN 1932-6203

Hoffmann, Eva, Victoria, C, Rhona, B and Faiz, A (2009) The devil is in the details: The importance of genetic and environmental factors for yeast meiosis. In: Protocols for Meiosis. Unset.

Hoffmann, Eva R, Eriksson, Emma, Herbert, Benjamin J and Borts, Rhona H (2005) MLH1 and MSH2 promote the symmetry of double-strand break repair events at the HIS4 hotspot in Saccharomyces cerevisiae. Genetics, 169. pp. 1291-1303. ISSN 0016-6731

Hoffmann, Eva R and Borts, Rhona H (2005) Trans Events Associated with Crossovers Are Revealed in the Absence of Mismatch Repair Genes in Saccharomyces cerevisiae. Genetics, 169. pp. 1305-1310. ISSN 0016-6731

Hoffmann, E R and Borts, R H (2004) Meiotic recombination intermediates and mismatch repair proteins. Cytogenetic and Genome Research, 107. pp. 232-248. ISSN 1424-859X

Abdullah, Mohammed F F, Hoffmann, Eva R, Cotton, V E and Borts, Rhona H (2004) A Role for MutL Homologue MLH2 in controlling heteroduplex formation and in regulating between two different crossover pathways in budding yeast. Cytogenetic and Genome Research, 107. pp. 180-190.

Hoffmann, Eva R, Shcherbakova, Polina V, Kunkel, Thomas A and Borts, Rhona H (2003) MLH1 Mutations Differentially Affect Meiotic Functions in Saccharomyces cerevisiae. Genetics, 163 (2). pp. 515-526. ISSN 0016-6731

Hjorth-Sørensen, Bjørn, Hoffmann, Eva R, Lissin, Nikolai M, Sewell, Andrew K and Jakobsen, Bent K (2001) Activation of heat shock transcription factor in yeast is not influenced by the levels of expression of heat shock proteins. Molecular Microbiology, 39 (4). pp. 914-923. ISSN 0950-382X