MRC Genome Damage and Stability Centre

Research Interests

The GDSC currently houses 20 research groups, all focused on different aspects of DNA damage responses and genome instability.

Molecular and Cell Biology

Alan Lehmann, Penny Jeggo, Keith Caldecott, Sherif El Khamisy, Mark O'Driscoll and Helfrid Hochegger are molecular and cell biologists studying DNA repair processes, cell cycle control and the replication of damaged DNA in human and other vertebrate cells. They have discovered deficiencies in these processes in several human genetic disorders and are attempting to relate the molecular defects to the clinical features of these disorders.

Yeast Molecular Genetics

Tony Carr, Felicity Watts and Jo Murray are yeast molecular geneticists, who use the fission yeast Schizosaccharomyces pombe as a model system to understand DNA damage responses in eukaryotic cells. They are investigating cell cycle checkpoints that are triggered by DNA damage and the effects of DNA damage on DNA replication.

Jessica Downs, Hideo Tsubouchi, Eva Hoffman, Matt Neale and Alessandro Bianchi use the budding yeast Saccharomyces cerevisiae as a model system to study chromatin remodelling, the regulation of double strand break formation in meiosis, and the role of telomeres in the regulation of the telomerase enzyme and the preservation of genome stability.

Biochemical, Cellular and Structural Properties of Multiprotein Systems

Laurence Pearl and Antony Oliver are structural biologists, studying the assembly, specificity, and regulation of multi-protein complexes involved in the recognition, repair and signalling of DNA damage.  They are also involved in the discovery and development of novel small-molecule inhibitors with application as drugs for the treatment of cancer and other diseases.

Aidan Doherty is a protein biochemist, studying biochemical, cellular and structural properties of multiprotein systems involved in DNA repair.