School of Life Sciences

Downs Lab

The Downs Laboratory

DNA on nucleosome

The Downs lab is interested in understanding the dynamic interplay between chromatin and genome stability.  Our research includes the study of chromatin structure and how it normally functions to maintain the integrity of the genome.  We are also interested in understanding how changes to the structure and composition of chromatin can influence DNA damage responses.

The aim of these strategies is to develop new insights about potential causes, treatments and biomarkers of cancer.



Our research work is funded by:

MRC logo


Jessica Downs

Professor of Genome Stability


Genome Damage and Stability Centre

University of Sussex


Brighton, BN1 9RQ


T +44 1273 678 369

Jessica Downs staff profile