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I receive a "not optimized..." message when running programs on a Mac

Changes implemented by Apple in macOS High Sierra 10.13.4 mean some applications will show this message:

The changes and additional help are outlined on this Apple help page



Adobe software has some specific issues running on High Sierra, which are detailed on this Adobe help page.

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This is question number 2876, which appears in the following categories:

Created by Mark Wilson on 28 June 2018 and last updated by Mark Wilson on 28 June 2018