Structural Basis of Biological Function (C7114)

15 credits, Level 5

Autumn teaching

This module builds on the topics of protein structure and function relationships introduced by first year modules Fundamentals of Cell and Molecular Biology and Biological Chemistry. Topics covered will include:

  • an introduction to protein structure and folding
  • the methods used to determine high-resolution protein structures
  • protein superfamilies
  • the functional properties of enzymes
  • the methods of analysis for exploring enzyme mechanism
  • how enzyme properties can be modified by protein engineering techniques to produce new enzymes with desirable properties, illustrated using a case study of subtilisin
  • the specificity of small molecule enzyme interactions, illustrated using an example of rationale drug design
  • the role of proteins as transducers of mechanical energy, explored by considering the role of actin and myosin in muscle contraction.

Teaching

54%: Lecture (Lecture, Post-lab, Pre-lab)
46%: Practical (Laboratory, Workshop)

Assessment

30%: Coursework (Computer-based examination, Report)
70%: Examination (Computer-based examination)

Contact hours and workload

This module is approximately 150 hours of work. This breaks down into about 31 hours of contact time and about 119 hours of independent study. The University may make minor variations to the contact hours for operational reasons, including timetabling requirements.

We regularly review our modules to incorporate student feedback, staff expertise, as well as the latest research and teaching methodology. We’re planning to run these modules in the academic year 2022/23. However, there may be changes to these modules in response to COVID-19, staff availability, student demand or updates to our curriculum. We’ll make sure to let our applicants know of material changes to modules at the earliest opportunity.

Courses

This module is offered on the following courses: