Genome Stability, Genetic Diseases and Cancer (C7129)
15 credits, Level 6
The design of new therapies for cancer depends on first understanding the molecular events that cause the disease. Genomic DNA is damaged spontaneously, by chemical carcinogens and by radiation. If unrepaired, this damage leads to mutations, cancer and other developmental disorders. All cells have evolved a sophisticated array of repair and response mechanisms to deal with DNA damage.
In this module, you aim to understand the molecular mechanisms that control DNA repair and appreciate how defects in genes involved in these repair processes are associated with different, in many cases cancer-prone, genetic disorders.
You will review and critically evaluate recently published experimental evidence, as advances in this area rely on a combination of biochemical analysis, genetic approaches and bioinformatics.
Teaching and assessment
We’re currently reviewing teaching and assessment of our modules in light of the COVID-19 situation. We’ll publish the latest information as soon as possible.
Contact hours and workload
This module is approximately 150 hours of work. This breaks down into about 25 hours of contact time and about 125 hours of independent study. The University may make minor variations to the contact hours for operational reasons, including timetabling requirements.
This module is running in the academic year 2021/22. We also plan to offer it in future academic years. However, there may be changes to this module in response to COVID-19, or due to staff availability, student demand or updates to our curriculum. We’ll make sure to let our applicants know of material changes to modules at the earliest opportunity.
It may not be possible to take some module combinations due to timetabling constraints. The structure of some courses means that the modules you choose first may determine whether later modules are core or optional.