Post Transcriptional Control of Gene Expression (Level 7) (843C1)

15 credits, Level 7 (Masters)

Spring teaching

This module investigates what happens to an mRNA from the time it is synthesised, subsequent processing, export into the cytoplasm and ultimate use to make protein. Whilst the processing of mRNA molecules is highly regulated, particularly at the levels of transcription and splicing (in eukaryotes), it is the translational machinery which allows the cell to select whether to use the mRNA to make protein at all; to decide which proteins to make; to decide how much protein to make and at what time in the cell cycle. This regulation is crucial to enable gene expression to be finely tuned with growth and allow cells to respond to environmental cues derived from hormones and nutrients.

This module takes an in-depth look at the molecular mechanisms controlling mRNA utilisation and degradation in eukaryotes focussing largely on translational control and what happens if the cell gets it wrong. The lecturers are active researchers in these subject areas, providing their up-to-date interpretation of an active and interesting research area that is relevant to the fundamental understanding of growth control and cancer.

Teaching

89%: Lecture
6%: One-to-one (Tutorial)
6%: Seminar (Class)

Assessment

30%: Coursework (Test)
70%: Examination (Unseen examination)

Contact hours and workload

This module is 150 hours of work. This breaks down into 25 hours of contact time and 125 hours of independent study.

This module is running in the academic year 2019/20. We also plan to offer it in future academic years. It may become unavailable due to staff availability, student demand or updates to our curriculum. We’ll make sure to let our applicants know of such changes to modules at the earliest opportunity.