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Publication Type J
Authors Nurunnabi, TR; Nahar, L; Al-Majmaie, S; Rahman, SM; Sohrab, MH; Billah, MM; Ismail, FM; Rahman, MM; Sharples, GP; Sarker, SD
Author Full Name Nurunnabi, Tauhidur Rahman; Nahar, Lutfun; Al-Majmaie, Shaymaa; Rahman, S. M. Mahbubur; Sohrab, Md. Hossain; Billah, Md. Morsaline; Ismail, Fyaz M. D.; Rahman, M. Mukhlesur; Sharples, George P.; Sarker, Satyajit D.
Title Anti-MRSA activity of oxysporone and xylitol from the endophytic fungus Pestalotia sp growing on the Sundarbans mangrove plant Heritiera fomes
Source PHYTOTHERAPY RESEARCH
Language English
Document Type Article
Author Keywords anti-MRSA; endophyte; Heritiera fomes; oxysporone; Pestalotia sp; xylitol
Keywords Plus STAPHYLOCOCCUS-AUREUS; METABOLITES
Abstract Heritiera fomes Buch.-Ham., a mangrove plant from the Sundarbans, has adapted to a unique habitat, muddy saline water, anaerobic soil, brackish tidal activities, and high microbial competition. Endophytic fungal association protects this plant from adverse environmental conditions. This plant is used in Bangladeshi folk medicine, but it has not been extensively studied phytochemically, and there is hardly any report on investigation on endophytic fungi growing on this plant. In this study, endophytic fungi were isolated from the surface sterilized cladodes and leaves of H. fomes. The antimicrobial activities were evaluated against two Gram-positive and two Gram-negative bacteria and the fungal strain, Candida albicans. Extracts of Pestalotia sp. showed activities against all test bacterial strains, except that the ethyl acetate extract was inactive against Escherichia coli. The structures of the purified compounds, oxysporone and xylitol, were elucidated by spectroscopic means. The anti-MRSA potential of the isolated compounds were determined against various MRSA strains, that is, ATCC 25923, SA-1199B, RN4220, XU212, EMRSA-15, and EMRSA-16, with minimum inhibitory concentration values ranging from 32 to 128 mu g/ml. This paper, for the first time, reports on the anti-MRSA property of oxysporone and xylitol, isolation of the endophyte Pestalotia sp. from H. fomes, and isolation of xylitol from a Pestalotia sp.
Author Address [Nurunnabi, Tauhidur Rahman; Nahar, Lutfun; Al-Majmaie, Shaymaa; Ismail, Fyaz M. D.; Sharples, George P.; Sarker, Satyajit D.] Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Med Chem & Nat Prod Res Grp, James Parsons Bldg,Byrom St, Liverpool L3 3AF, Merseyside, England; [Nurunnabi, Tauhidur Rahman; Rahman, S. M. Mahbubur; Billah, Md. Morsaline] Khulna Univ, Biotechnol & Genet Engn Discipline, Khulna, Bangladesh; [Sohrab, Md. Hossain] BCSIR Labs, Pharmaceut Sci Res Div, Dhaka, Bangladesh; [Rahman, M. Mukhlesur] Univ East London, Sch Hlth Sport & Biosci, Med Res Grp, Water Lane, London E15 4LZ, England
Reprint Address Sarker, SD (reprint author), Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Med Chem & Nat Prod Res Grp, James Parsons Bldg,Byrom St, Liverpool L3 3AF, Merseyside, England.
E-mail Address s.sarker@ljmu.ac.uk
ORCID Number Sarker, Satyajit/0000-0003-4038-0514; Rahman, Md Mukhlesur/0000-0001-8180-7970
Funding Agency and Grant Number World Bank; Robert S McNamara Fellowship Programme
Funding Text World Bank, Grant/Award Number: Robert McNamara Fellowship; Robert S McNamara Fellowship Programme
Cited Reference Count 32
Times Cited 1
Total Times Cited Count (WoS, BCI, and CSCD) 1
Publisher WILEY
Publisher City HOBOKEN
Publisher Address 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
ISSN 0951-418X
29-Character Source Abbreviation PHYTOTHER RES
ISO Source Abbreviation Phytother. Res.
Publication Date FEB
Year Published 2018
Volume 32
Issue 2
Beginning Page 348
Ending Page 354
Digital Object Identifier (DOI) 10.1002/ptr.5983
Page Count 7
Web of Science Category Chemistry, Medicinal; Pharmacology & Pharmacy
Subject Category Pharmacology & Pharmacy
Document Delivery Number FV0YI
Unique Article Identifier WOS:000424287300018
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