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Publication Type J
Authors Cavallaro, V., C. J. Baier, M. G. Murray, A. Estevez-Braun and A. P. Murray
Title Neuroprotective effects of Flaveria bidentis and Lippia salsa extracts on SH-SY5Y cells
Source South African Journal of Botany
Language English
Author Keywords Neuroprotection SH-SY5Y cells Acetylcholinesterase inhibition Halophytes oxidative stress acetylcholinesterase activity alzheimers-disease flavonoids inhibitors aggregation quercetin food Plant Sciences
Abstract Halophyte plants have to survive in a hostile environment by developing adaptive responses. One of these strategies is the production of several protective molecules which make these plants an interesting source of bioactive compounds. Significant acetylcholinesterase inhibition was observed for ethanolic extracts obtained from Lippia salsa Griseb. (Verbenaceae) and Moeda bidentis (L.) Kuntze (Asteraceae), two plants that are widely distributed in the salt marsh Salitral de la Vidriera These results encouraged us to further study the active constituents and the potential neuroprotective properties of these plants. The flavonoids luteolin (1) and apigenin (2) were identified as the active components of L. salsa, while 6-methoxykaempferol-3-sulfate (3) was obtained from F. bidentis. In addition, we investigated the cytotoxicity, cellular protection against K+-depolarization and antioxidant activity in SH-SY5Y neuroblastoma cells for these extracts and compound 3. Results demonstrated that beyond acting as acetylcholinesterase inhibitors, they also exhibited neuroprotective effects against KCl-induced-Ca2+ overload and oxidative stress. (C) 2018 SAAB. Published by Elsevier B.V. All rights reserved.
Author Address [Cavallaro, V.; Murray, A. P.] Univ Nacl Sur, Dept Quim, CONICET, INQUISUR, Ave Alem 1253,B8000CPB, Bahia Blanca, Buenos Aires, Argentina. [Baier, C. J.] UNS, Consejo Nacl Invest Cient & Tecn, Inst Invest Bioquim Bahia Blanca INIBIBB, CONICET,DBByF, Bahia Blanca, Buenos Aires, Argentina. [Murray, M. G.] Univ Nacl Sur, Dept Biol Bioquim & Farm, CONICET, INBIOSUR, San Juan 670,B8000CPB, Bahia Blanca, Buenos Aires, Argentina. [Estevez-Braun, A.] Univ La Laguna, Dept Quim Organ, CIBICAN, Inst Univ Bioorgan Antonio Gonzalez, Avda Astrofis Fco Sanchez 2 La Laguna, Tenerife, Spain. Murray, AP (reprint author), Univ Nacl Sur, Dept Quim, CONICET, INQUISUR, Ave Alem 1253,B8000CPB, Bahia Blanca, Buenos Aires, Argentina. apmurray@uns.edu.ar
ISSN 0254-6299
ISBN 0254-6299
29-Character Source Abbreviation S. Afr. J. Bot.
Publication Date Nov
Year Published 2018
Volume 119
Beginning Page 318-324
Digital Object Identifier (DOI) 10.1016/j.sajb.2018.10.006
Unique Article Identifier WOS:000449688300039
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