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Publication Type J
Authors Orhan, N; Gokbulut, A; Orhan, DD
Author Full Name Orhan, N.; Gokbulut, A.; Orhan, D. Deliorman
Title Antioxidant potential and carbohydrate digestive enzyme inhibitory effects of five Inula species and their major compounds
Source SOUTH AFRICAN JOURNAL OF BOTANY
Language English
Document Type Article
Author Keywords Antidiabetic; Antioxidant; Asteraceae; Inula; Elecampane; Yellowhead
Keywords Plus ANTIMICROBIAL ACTIVITIES; ALPHA-GLUCOSIDASE; AQUEOUS-EXTRACT; GENUS INULA; PLANTS; BRITANNICA; VISCOSA; AMYLASE; FLOWER; MICE
Abstract The present study was designed to examine in-vitro antidiabetic activities of different extracts of flowers, leaves and roots of Inula helenium ssp. turcoracemosa, L montbretiana, I. peacockiana, I thapsoides ssp. thapsoides and I. viscosa extracts. I. viscosa and I. montbretiana flower, I. thapsoides and I. viscosa leaf and I. helenium root methanol extracts exhibited remarkable alpha-glucosidase inhibitory activity. Additionally, alpha-amylase inhibitory activities of the extracts were moderate at only 3000 mu g/mL. Based on the results of in-vitro antidiabetic activity tests; antioxidant activities, total phenol and flavonoid contents of the most promising extracts were evaluated. To identify compounds responsible for the antidiabetic activity, major compounds of Inula species were analyzed for their in-vitro enzyme inhibitory activity. Quercetin, luteolin and rutin exhibited a significant inhibition on alpha-glucosidase at 10 mM concentrations. Consequently, Inula species could potentially be used by diabetic patients for their antidiabetic and antioxidant activities. (C) 2017 SAAB. Published by Elsevier B.V. All rights reserved.
Author Address [Orhan, N.; Orhan, D. Deliorman] Gazi Univ, Fac Pharm, Dept Pharmacognosy, TR-06330 Ankara, Turkey; [Gokbulut, A.] Ankara Univ, Fac Pharm, Dept Pharmacognosy, TR-06100 Ankara, Turkey
Reprint Address Orhan, DD (reprint author), Gazi Univ, Fac Pharm, Dept Pharmacognosy, TR-06330 Ankara, Turkey.
E-mail Address nympis@gmail.com; alper.gokbulut@pharmacy.ankara.edu.tr; didemdeliorman@gmail.com
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Cited Reference Count 27
Publisher ELSEVIER SCIENCE BV
Publisher City AMSTERDAM
Publisher Address PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
ISSN 0254-6299
29-Character Source Abbreviation S AFR J BOT
ISO Source Abbreviation S. Afr. J. Bot.
Publication Date JUL
Year Published 2017
Volume 111
Beginning Page 86
Ending Page 92
Digital Object Identifier (DOI) 10.1016/j.sajb.2017.03.040
Subject Category 7
Document Delivery Number Plant Sciences
Unique Article Identifier Plant Sciences
Plants associated with this reference

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