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Version 3.21
Publication Type J
Authors Faral-Tello, P; Mirazo, S; Dutra, C; Perez, A; Geis-Asteggiante, L; Frabasile, S; Koncke, E; Davyt, D; Cavallaro, L; Heinzen, H; Arbiza, J
Author Full Name Faral-Tello, Paula; Mirazo, Santiago; Dutra, Carmelo; Perez, Andres; Geis-Asteggiante, Lucia; Frabasile, Sandra; Koncke, Elina; Davyt, Danilo; Cavallaro, Lucia; Heinzen, Horacio; Arbiza, Juan
Title Cytotoxic, Virucidal, and Antiviral Activity of South American Plant and Algae Extracts
Language English
Document Type Article
Abstract Herpes simplex virus type 1 (HSV-1) infection has a prevalence of 70% in the human population. Treatment is based on acyclovir, valacyclovir, and foscarnet, three drugs that share the same mechanism of action and of which resistant strains have been isolated from patients. In this aspect, innovative drug therapies are required. Natural products offer unlimited opportunities for the discovery of antiviral compounds. In this study, 28 extracts corresponding to 24 plant species and 4 alga species were assayed in vitro to detect antiviral activity against HSV-1. Six of the methanolic extracts inactivated viral particles by direct interaction and 14 presented antiviral activity when incubated with cells already infected. Most interesting antiviral activity values obtained are those of Limonium brasiliense, Psidium guajava, and Phyllanthus niruri, which inhibit HSV-1 replication in vitro with 50% effective concentration (EC50) values of 185, 118, and 60 mu g/mL, respectively. For these extracts toxicity values were calculated and therefore selectivity indexes (SI) obtained. Further characterization of the bioactive components of antiviral plants will pave the way for the discovery of new compounds against HSV-1.
Author Address [Faral-Tello, Paula; Mirazo, Santiago; Frabasile, Sandra; Koncke, Elina; Arbiza, Juan] Univ Republica, Fac Ciencias, Secc Virol, Montevideo 11400, Uruguay; [Dutra, Carmelo; Perez, Andres; Geis-Asteggiante, Lucia; Davyt, Danilo; Heinzen, Horacio] Univ Republica, Fac Quim, Catedra Prod Nat, Montevideo 11800, Uruguay; [Cavallaro, Lucia] Univ Buenos Aires, Fac Farm & Bioquim, Catedra Virol, RA-1113 Buenos Aires, DF, Argentina
Reprint Address Arbiza, J (reprint author), Univ Republica, Fac Ciencias, Secc Virol, Montevideo 11400, Uruguay.
E-mail Address jarbiza@fcien.edu.uy
ORCID Number Davyt, Danilo/0000-0002-4141-2322; Geis Asteggiante, Lucia/0000-0002-4305-3044
Funding Agency and Grant Number Programa de Desarrollo Tecnologico (PDT) [75/07]; Direccion de Innovacion Ciencia y Tecnologia para el Desarrollo (DICyT); CONICYT-BID [321]; Ministerio de Educacion y Cultura Montevideo, Uruguay; Agencia Nacional de Investigacion e Innovacion (ANII) [BE_INI_2008_108]
Funding Text This work was supported by grants from the Programa de Desarrollo Tecnologico (PDT 75/07), Direccion de Innovacion Ciencia y Tecnologia para el Desarrollo (DICyT), and CONICYT-BID (321), Ministerio de Educacion y Cultura Montevideo, Uruguay. P. Faral-Tello's fellowship was supported by grants of Agencia Nacional de Investigacion e Innovacion (ANII) through its program Sistema Nacional de Becas (BE_INI_2008_108). P. Faral-Tello's and S. Mirazo contributed equally to this work. The authors would like to thank Agencia Nacional de Investigacion de Innovacion (ANII) and Programa de Desarrollo de Ciencias Basicas (PEDECIBA).
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Cited Reference Count 25
Times Cited 7
Total Times Cited Count (WoS, BCI, and CSCD) 7
Publisher City NEW YORK
Publisher Address 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
ISSN 1537-744X
29-Character Source Abbreviation SCI WORLD J
ISO Source Abbreviation Sci. World J.
Year Published 2012
Article Number 174837
Digital Object Identifier (DOI) 10.1100/2012/174837
Subject Category 5
Document Delivery Number Multidisciplinary Sciences
Unique Article Identifier Science & Technology - Other Topics
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