eHALOPH - Halophytes Database

Publication Type	J
Authors	Cui, ZH; Guo, ZQ; Miao, JH; Wang, ZW; Li, QQ; Chai, XY; Li, MH
Author Full Name	Cui, Zhanhu; Guo, Zhiqin; Miao, Jianhua; Wang, Zhenwang; Li, Qianquan; Chai, Xingyun; Li, Minhui
Title	The genus Cynomorium in China: An ethnopharmacological and phytochemical review
Source	JOURNAL OF ETHNOPHARMACOLOGY
Language	English
Document Type	Review
Author Keywords	Cynomorium; Cynomorium songaricum; Cynomorium coccineum; Traditional uses; Phytochemistry; Pharmacology
Keywords Plus	HUMAN NEUROBLASTOMA-CELLS; IMMATURE WISTAR RATS; WITHANIA-SOMNIFERA; SONGARICUM; EXTRACTS; CONSTITUENTS; COCCINEUM; DERIVATIVES; ENDURANCE; PROTEASE
Abstract	Ethnopharmacological relevance: Species of the genus Cynomorium (Cynomoriaceae), including C. songaricum Rupr. and C. coccineum L., have a long history of use in traditional medicine to treat various ailments such as impotence, premature ejaculation, kidney-yang deficiency, spermatorrhea, colic, and stomach ulcers. In addition, these species are Used in health foods, tea, and cosmetics. Aim of the review: The aim of this review is to provide comprehensive information on the botany, traditional uses, phytochemistry, pharmacological research, and toxicology of C. songaricum and C. coccineum and to explore the therapeutic potential and future research opportunities of these species. Materials and methods: All available information on C. songaricum and C. coccineum was collected via electronic search (using PubMed, ACS, CNKI, Google Scholar, Baidu Scholar, and Web of Science). Results: The ethnomedical uses of C. songaricum and C. coccineum in Saudi Arabia, China, Afghanistan, Mongolia, and Iran for several types of ailments were recorded. A phytochemical investigation revealed the presence of flavonoids, terpenoids, phloroglucinol adducts, saccharides, phenylpropanoids, steroids, organic acids, and other compounds. The crude extracts and pure compounds from C. songaricum and C. coccineum exhibited a wide spectrum of in vitro and in vivo pharmacological activity, including anti-fatigue, anti-hypoxia, anti-oxidation, anti-diabetic, immune system modulating, and antiviral activity. Conclusions: Cynomorium species have emerged as a source of traditional medicine. Many studies have provided evidence for the therapeutic efficacy of these species in treating various conditions and possible mechanisms. However, further research is required for the development of new drugs and therapies for the treatment of various diseases, especially cancer and diabetes. Therefore, this review on the ethnopharmacology, phytochemistiy, and toxicity of Cynomorium species will provide helpful data for further studies and commercial exploitation of the species. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
Author Address	[Cui, Zhanhu; Miao, Jianhua; Li, Minhui] Guangxi Bot Garden Med Plants, Nanning 530023, Peoples R China; [Cui, Zhanhu; Wang, Zhenwang; Li, Qianquan; Li, Minhui] Baotou Med Coll, Baotou 014060, Inner Mongolia, Peoples R China; [Guo, Zhiqin; Chai, Xingyun] Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
Reprint Address	Chai, XY (reprint author), Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China.
E-mail Address	xingyunchai@yeah.net; li_minhui@yahoo.cn
Funding Agency and Grant Number	Chinese National Natural Science Foundation [81060372]; Chinese ministry of education [211033];
Funding Text	This work was financially supported by a grant (81060372) from the Chinese National Natural Science Foundation, the key project of the Chinese ministry of education (211033) and the
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Cited Reference Count	136
Times Cited	12
Total Times Cited Count (WoS, BCI, and CSCD)	15
Publisher	ELSEVIER IRELAND LTD
Publisher City	CLARE
Publisher Address	ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
ISSN	0378-8741
29-Character Source Abbreviation	J ETHNOPHARMACOL
ISO Source Abbreviation	J. Ethnopharmacol.
Publication Date	MAY 2
Year Published	2013
Volume	147
Issue	1
Beginning Page	1
Ending Page	15
Digital Object Identifier (DOI)	10.1016/j.jep.2013.01.020
Page Count	15
Web of Science Category	Plant Sciences; Chemistry, Medicinal; Integrative & Complementary Medicine; Pharmacology & Pharmacy
Subject Category	Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary Medicine
Document Delivery Number	136TJ
Unique Article Identifier	WOS:000318386000001
Plants associated with this reference	Cynomorium coccineum